Donepezil in low micromolar concentrations modulates voltage-gated potassium currents in pyramidal neurons of rat hippocampus

Biochemical and Biophysical Research Communications

Volumn 430, Issue 3, 2013, Pages 1066-1071

  Solntseva, Elena I ^a   Bukanova, Julia V ^a   Skrebitsky, Vladimir G ^a  

^a RESEARCH CENTER OF NEUROLOGY   (Russian Federation)

Author keywords

Donepezil; Hippocampus; K+ current; Patch clamp; Pyramidal neurons

Indexed keywords

DONEPEZIL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; DOSE RESPONSE; HIPPOCAMPUS; NERVE CELL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; CHOLINESTERASE INHIBITORS; DELAYED RECTIFIER POTASSIUM CHANNELS; HIPPOCAMPUS; INDANS; PATCH-CLAMP TECHNIQUES; PIPERIDINES; PYRAMIDAL CELLS; RATS;

MAMMALIA; RATTUS;

EID: 84872497551     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.12.037     Document Type: Article

References (23)

1. Doody R.S., Geldmacher D.S., Farlow M.R., Sun Y., Moline M., Mackell J. Efficacy and safety of donepezil 23 mg versus donepezil 10 mg for moderate-to-severe Alzheimer's Disease: a subgroup analysis in patients already taking or not taking concomitant memantine. Dement. Geriatr. Cogn. Disord. 2012, 33:164-173.
2. Howard R., McShane R., Lindesay J., Ritchie C., Baldwin A., Barber R., et al. Donepezil and memantine for moderate-to-severe Alzheimer's disease. N. Engl. J. Med. 2012, 366:893-903.
3. Chung K.A., Lobb B.M., Nutt J.G., Horak F.B. Effects of a central cholinesterase inhibitor on reducing falls in Parkinson disease. Neurology 2010, 75:1263-1269.
4. Min D., Mao X., Wu K., Cao Y., Guo F., Zhu S., et al. Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils. Neurosci. Lett. 2012, 510:29-33.
5. Yuan H., Wang W.P., Feng N., Wang L., Wang X.L. Donepezil attenuated oxygen-glucose deprivation insult by blocking Kv2.1 potassium channels. Eur. J. Pharmacol. 2011, 657:76-83.
6. Niitsu T., Iyo M., Hashimoto K. Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases. Curr. Pharm. Des. 2012, 18:875-883.
7. Relkin N.R. Beyond symptomatic therapy: a re-examination of acetylcholinesterase inhibitors in Alzheimer's disease. Expert. Rev. Neurother. 2007, 7:735-748.
8. Pannaccione A., Boscia F., Scorziello A., Adornetto A., Castaldo P., Sirabella R., et al. Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death. Mol. Pharmacol. 2007, 72:665-673.
9. Yu H.B., Li Z.B., Zhang H.X., Wang X.L. Role of potassium channels in Abeta(1-40)-activated apoptotic pathway in cultured cortical neurons. J. Neurosci. Res. 2006, 84:1475-1484.
10. Solntseva E.I., Bukanova J.V., Marchenko E., Skrebitsky V.G. Donepezil is a strong antagonist of voltage-gated calcium and potassium channels in molluscan neurons. Comp. Biochem. Physiol. Part C 2007, 144:319-326.
11. Yu B., Hu G.-Y. Donepezil blocks voltage-gated ion channels in rat dissociated hippocampal neurons. Eur. J. Pharmcol. 2005, 508:15-21.
12. Yang T., Kanki H., Roden D.M. Phosphorylation of the IKs channel complex inhibits drug block. Circulation 2003, 108:132-134.
13. Vorobjev V.S. Vibrodissociation of sliced mammalian nervous tissue. J. Neurosci. Meth. 1991, 38:145-150.
14. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current-recording from cells and cell-free membrane patches. Pflugers Arch. 1981, 391:85-100.
15. + currents in dissociated rat hippocampal neurons. Br. J. Pharmacol. 2003, 140:907-912.
16. Gutman G.A., Chandy K.G., Grissmer S., Lazdunski M., McKinnon D., Pardo L.A., et al. International union of pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol. Rev. 2005, 57:473-508.
17. Storm J.F. Potassium currents in hippocampal pyramidal cells. Prog. Brain Res. 1990, 83:161-187.
18. + channels of molluscan neurons. Cell. Mol. Neurobiol. 2009, 29:219-224.
19. 2+ blockade of DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes. J. Gen. Physiol. 1994, 103:203-216.
20. Lopatin A.N., Makhina E.N., Nichols C.G. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 1994, 372:366-369.
21. Rogers S.L., Doody R.S., Mohs R.S., Friedhoff L.T. Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study, Donepezil Study Group. Arch. Intern. Med. 1998, 158:1021-1031.
22. Kosasa T., Kuriya Y., Matsui K., Yamanishi Y. Inhibitory effect of orally administered donepezil hydrochloride (E2020), a novel treatment for Alzheimer's disease, on cholinesterase activity in rats. Eur. J. Pharmacol. 2000, 389:173-179.
23. Pan Y.P., Xu X.H., Wang X.L. Galantamine blocks delayed rectifier, but not transient outward potassium current in rat dissociated hippocampal pyramidal neurons. Neurosci. Lett. 2003, 336:37-40.