Lymphangiogenesis and Prognostic Significance of Vascular Endothelial Growth Factor C in Gastro-oesophageal Junction Adenocarcinoma

International Journal of Experimental Pathology

Volumn 94, Issue 1, 2013, Pages 39-46

  Xie, Liang Xi ^a   Zhai, Tian Tian ^a   Yang, Li Ping ^b   Yang, Eleanor ^c   Zhang, Xiao Hui ^a   Chen, Jiong Yu ^a   Zhang, Hao ^a  

^a SHANTOU UNIVERSITY   (China)

^b Department of Ophthalmology   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Disease free survival rate; Gastro oesophageal junction adenocarcinoma; Lymphangiogenesis; Lymphatic vessel density; Prognosis; Vascular endothelial growth factor C

Indexed keywords

VASCULOTROPIN C;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER PROGNOSIS; CANCER SIZE; CANCER STAGING; CANCER SURGERY; DISEASE FREE SURVIVAL; FEMALE; GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA; GASTROINTESTINAL CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LOWER ESOPHAGUS SPHINCTER; LYMPH NODE METASTASIS; LYMPHANGIOGENESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; DISEASE-FREE SURVIVAL; ESOPHAGEAL NEOPLASMS; ESOPHAGOGASTRIC JUNCTION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; STOMACH NEOPLASMS; TIME FACTORS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 84872472505     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/iep.12005     Document Type: Article

References (28)

1. Akagi K., Ikeda Y., Miyazaki M. et al. (2000) Vascular endothelial growth factor-C (VEGF-C) expression in human colorectal cancer tissues. Br. J. Cancer 83, 887-891.
2. Amioka T., Kitadai Y., Tanaka S. et al. (2002) Vascular endothelial growth factor-C expression predicts lymph node metastasis of human gastric carcinomas invading the submucosa. Eur. J. Cancer 38, 1413-1419.
3. Bunone G., Vigneri P., Mariani L. et al. (1999) Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features. Am. J. Pathol. 155, 1967-1976.
4. Cunnick G.H., Jiang W.G., Gomez K.F., Mansel R.E. (2002) Lymphangiogenesis and breast cancer metastasis. Histol. Histopathol. 17, 863-870.
5. Dadras S.S., Paul T., Bertoncini J. et al. (2003) Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am. J. Pathol. 162, 1951-1960.
6. Gao P., Zhou G.Y., Zhang Q.H. et al. (2009) Lymphangiogenesis in gastric carcinoma correlates with prognosis. J. Pathol. 218, 192-200.
7. Jeltsch M., Kaipainen A., Joukov V. et al. (1997) Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 276, 1423-1425.
8. Joory K.D., Levick J.R., Mortimer P.S., Bates D.O. (2006) Vascular endothelial growth factor-C (VEGF-C) expression in normal human tissues. Lymphat. Res. Biol. 4, 73-82.
9. Joukov V., Pajusola K., Kaipainen A. et al. (1996) A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 15, 1751.
10. Kabashima A., Maehara Y., Kakeji Y., Sugimachi K. (2001) Overexpression of vascular endothelial growth factor C is related to lymphogenous metastasis in early gastric carcinoma. Oncology 60, 146-150.
11. Kaipainen A., Korhonen J., Mustonen T. et al. (1995) Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc. Natl Acad. Sci. USA 92, 3566-3570.
12. Karkkainen M.J., Haiko P., Sainio K. et al. (2004) Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat. Immunol. 5, 74-80.
13. Kukk E., Lymboussaki A., Taira S. et al. (1996) VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development 122, 3829-3837.
14. Nishida N., Yano H., Komai K., Nishida T., Kamura T., Kojiro M. (2004) Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma. Cancer 101, 1364-1374.
15. Oh S.J., Jeltsch M.M., Birkenhager R. et al. (1997) VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane. Dev. Biol. 188, 96-109.
16. Omachi T., Kawai Y., Mizuno R. et al. (2007) Immunohistochemical demonstration of proliferating lymphatic vessels in colorectal carcinoma and its clinicopathological significance. Cancer Lett. 246, 167-172.
17. Rasanen J.V., Sihvo E.I., Knuuti M.J. et al. (2003) Prospective analysis of accuracy of positron emission tomography, computed tomography, and endoscopic ultrasonography in staging of adenocarcinoma of the esophagus and the esophagogastric junction. Ann. Surg. Oncol. 10, 954-960.
18. Rubbia-Brandt L., Terris B., Giostra E., Dousset B., Morel P., Pepper M.S. (2004) Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors. Clin. Cancer Res. 10, 6919-6928.
19. Skobe M., Hawighorst T., Jackson D.G. et al. (2001) Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat. Med. 7, 192-198.
20. Su J.L., Yang P.C., Shih J.Y. et al. (2006) The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 9, 209-223.
21. Su J.L., Yen C.J., Chen P.S. et al. (2007) The role of the VEGF-C/VEGFR-3 axis in cancer progression. Br. J. Cancer 96, 541-545.
22. Swisher S.G., Pisters P.W., Komaki R., Lahoti S., Ajani J.A. (2000) Gastroesophageal junction adenocarcinoma. Curr. Treat. Options Oncol. 1, 387-398.
23. Takahashi A., Kono K., Itakura J. et al. (2002) Correlation of vascular endothelial growth factor-C expression with tumor-infiltrating dendritic cells in gastric cancer. Oncology 62, 121-127.
24. Tsurusaki T., Kanda S., Sakai H. et al. (1999) Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis. Br. J. Cancer 80, 309-313.
25. Ueda M., Terai Y., Yamashita Y. et al. (2002) Correlation between vascular endothelial growth factor-C expression and invasion phenotype in cervical carcinomas. Int. J. Cancer 98, 335-343.
26. Weidner N. (1995) Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res. Treat. 36, 169-180.
27. Xiang Z., Zeng Z., Tang Z. et al. (2009) Increased expression of vascular endothelial growth factor-C and nuclear CXCR4 in hepatocellular carcinoma is correlated with lymph node metastasis and poor outcome. Cancer J. 15, 519-525.
28. Yonemura Y., Endo Y., Fujita H. et al. (1999) Role of vascular endothelial growth factor C expression in the development of lymph node metastasis in gastric cancer. Clin. Cancer Res. 5, 1823-1829.