A method for reliable voluntary oral administration of a fixed dosage (mg/kg) of chronic daily medication to rats

Laboratory Animals

Volumn 46, Issue 4, 2012, Pages 318-324

  Corbett, Adrian ^a   Mcgowin, Audrey ^b   Sieber, Scott ^a   Flannery, Tiffany ^a   Sibbitt, Bethany ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b WRIGHT STATE UNIVERSITY   (United States)

Author keywords

Fluoxetine; HPLC; Norfluoxetine; Rats; Stress; Voluntary oral ingestion

Indexed keywords

ASCORBIC ACID; ATORVASTATIN; FLUOXETINE; NORFLUOXETINE; PAROXETINE; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOUGH; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; EXPERIMENTAL MODEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INGESTION; LONG EVANS RAT; MALE; NONHUMAN; RAT; SINGLE DRUG DOSE; SPRAGUE DAWLEY RAT; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMAL FEED; ANIMALS; ANIMALS, OUTBRED STRAINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG COMBINATIONS; DRUG DELIVERY SYSTEMS; FEMALE; FLUOXETINE; MALE; PHARMACEUTICAL PREPARATIONS; PILOT PROJECTS; RATS; SEROTONIN UPTAKE INHIBITORS; SPECIES SPECIFICITY; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 84872461129     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2012.012018     Document Type: Article

References (15)

1. Lichtenwalner RJ, Parent JM. Adult neurogenesis and the ischemic forebrain. J Cereb Blood Flow Metab 2006;26:1-20
2. Yang Z, Levison SW. Perinatal hypoxic/ischemic brain injury induces persistent production of striatal neurons from subventricular zone progenitors. Dev Neurosci 2007;29:331-40
3. Pittenger C, Duman RS. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 2008;33:88-109
4. Warner-Schmidt JL, Duman RS. Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. Hippocampus 2006;16:239-49
5. Mirescu C, Gould E. Stress and adult neurogenesis. Hippocampus 2006;16:233-8
6. Aguilera G, Kiss A, Sunar-Akbasak B. Hyperreninemic hypoaldosteronism after chronic stress in the rat. J Clin Invest 1995;96:1512-19
7. Pung T, Zimmerman K, Klein B, Ehrich M. Corticosterone in drinking water: altered kinetics of a single oral dose of corticosterone and concentrations of plasma sodium, albumin, globulin, and total protein. Toxicol Ind Health 2003;19:171-82
8. Kalliokoski O, Jacobsen KR, Hau J, Abelson KS. Serum concentrations of buprenorphine after oral and parenteral administration in male mice. Vet J 2011;187:251-4
9. Leach MC, Bailey HE, Dickinson AL, Roughan JV, Flecknell PA. A preliminary investigation into the practicality of use and duration of action of slow-release preparations of morphine and hydromorphone in laboratory rats. Lab Anim 2010;44:59-65
10. Hiemke C, Hartter S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacol Ther 2000;85:11-28
11. Unceta N, Ugarte A, Sanchez A, Gomez-Caballero A, Goicolea MA, Barrio RJ. Development of a stir bar sorptive extraction based HPLC-FLD method for the quantification of serotonin reuptake inhibitors in plasma, urine and brain tissue samples. J Pharm Biomed Anal 2010;51:178-85
12. Montoya CP, Campbell-Hope LJ, Pemberton KD, Dunnett SB. The 'staircase test': a measure of independent forelimb reaching and grasping abilities in rats. J Neurosci Methods 1991;36:219-28
13. Goldkuhl R, Carlsson HE, Hau J, Abelson KS. Effect of subcutaneous injection and oral voluntary ingestion of buprenorphine on post-operative serum corticosterone levels in male rats. Eur Surg Res 2008;41:272-8
14. Flecknell PA, Roughan JV, Stewart R. Use of oral buprenorphine ('buprenorphine jello') for postoperative analgesia in rats - a clinical trial. Lab Anim 1999;33:169-74
15. Atcha Z, Rourke C, Neo AH, et al. Alternative method of oral dosing for rats. J Am Assoc Lab Anim Sci 2010;49:335-43