Alternative method of oral dosing for rats

Journal of the American Association for Laboratory Animal Science

Volumn 49, Issue 3, 2010, Pages 335-343

  Atcha, Zeenat ^a   Rourke, Claire ^a   Neo, Aveline H P ^a   Goh, Catherine W H ^a   Lim, Jean S K ^a   Aw, Chiu Cheong ^a   Browne, Edward R ^a   Pemberton, Darrel J ^a,b  

^a GlaxoSmithKline R and D China   (Singapore)

^b Neurosciences Division Johnson and Johnson PRF   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DONEPEZIL; GALANTAMINE; NICOTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; FEEDING; MALE; NONHUMAN; PALATABILITY; RAT;

ADMINISTRATION, ORAL; ANIMALS; BEHAVIOR, ANIMAL; GALANTAMINE; INDANS; LABORATORY ANIMAL SCIENCE; MALE; NICOTINE; NOOTROPIC AGENTS; PIPERIDINES; RATS; RECOGNITION (PSYCHOLOGY); STRESS, PHYSIOLOGICAL; SUCROSE; SYRINGES; TIME FACTORS;

ANIMALIA; RATTUS; RODENTIA;

EID: 77953212868     PISSN: 15596109     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Atcha Z, Chen WS, Ong AB, Wong FK, Neo A, Browne ER, Witherington J, Pemberton DJ. 2009. Cognitive enhancing effects of ghrelin receptor agonists. Psychopharmacology (Berl) 206: 415-427.
2. Barnett SW. 2007. Manual of animal technology, 1st ed. Hoboken (NJ): Wiley-Blackwell.
3. Beckett AH, Triggs EJ. 1967. Buccal absorption of basic drugs and its application as an in vivo model of passive drug transfer through lipid membranes. J Pharm Pharmacol 19 Suppl:31S-41S.
4. Bonnichsen M, Dragsted N, Hansen AK. 2005. The welfare impart of gavaging laboratory rats. Anim Welf 14:223-227. (Pubitemid 41057356)
5. Ennaceur A, Delacour J. 1988. A new one-trial test for neurobiological studies of memory in rats I: behavioral data. Behav Brain Res 31:47-59.
6. Gao XM, Hashimoto T, Cooper TB, Tamminga CA. 1997. The dose-response characteristics of rat oral dyskinesias with chronic haloperidol or clozapine administration. J Neural Transm 104:97-104. (Pubitemid 27073233)
7. Germann PG, Ockert D. 1994. Granulomatous inflammation of the oropharyngeal cavity as a possible cause for unexpected high mortality in a Fischer 344 rat carcinogenicity study. Lab Anim Sci 44:338-343.
8. Huang-Brown KM, Guhad FA. 2002. Chocolate, an effective means of oral drug delivery in rats. Lab Anim (NY) 31:34-36.
9. Matsui K, Mishima M, Nagai Y, Yuzuriha T, Yoshimura T. 1999. Absorption, distribution, metabolism, and excretion of donepezil (Aricept) after a single oral administration to rat. Drug Metab Dispos 27:1406-1414.
10. Messier C, White NM. 1984. Contingent and noncontingent actions of sucrose and saccharin reinforcers: effects of taste preference and memory. Physiol Behav 32:195-203. (Pubitemid 14125760)
11. National Advisory Committee for Laboratory Animal Research. [Internet]. 2004. Guidelines on the care and use of animals for scientific purposes. [Cited Jul 2009]. Available at http://www.ava.gov.sg/NR/rdonlyres/C64255C0-3933-4EBC- B869-84621-A9BF682/8338/Attach3-AnimalsforScientificPurposes.PDF
12. Office of Animal Care and Use. [Internet]. 2008. Guidelines for survival bleeding of mice and rats. [Cited Jul 2009]. Available at http://oacu.od.nih. gov/ARAC/survival.pdf
13. Õkva K, Tamoševiciute E, Cižiute A, Pokk P, Rukšenas O, Nevalainen T. 2006. Refinements for intragastric gavage in rats. Scandinavian J Lab Anim Sci 33:243-252.
14. Schleimer SB, Johnston GAR, Henderson JM. 2005. Novel oral drug administration in an animal model of neuroleptic therapy. J Neurosci Methods 146:159-164.
15. Shojaei AH. 1998. Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Pharm Sci 1:15-30.
16. Smart JD. 2005. Buccal drug delivery. Expert Opin Drug Deliv 2:507-517.
17. Wheatley JL. 2002. A gavage dosing apparatus with flexible catheter provides a less stressful gavage technique in the rat. Lab Anim (NY) 31:53-56.
18. Turner PV, Albassam M, Walker RM. 2001. The effects of overnight fasting, feeding, or sucrose supplementation prior to necropsy in rats. Contemp Top Lab Anim Sci 40:36-40. (Pubitemid 33678778)