Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway

Blood

Volumn 121, Issue 3, 2013, Pages 499-509

  Li, Yonghui ^a   Gao, Li ^a   Luo, Xufeng ^a   Wang, Lili ^a   Gao, Xiaoning ^a   Wang, Wei ^a   Sun, Junzhong ^a   Dou, Liping ^a   Li, Jingxin ^a   Xu, Chengwang ^a   Wang, Lixin ^a   Zhou, Minhang ^a   Jiang, Mengmeng ^a   Zhou, Jihao ^a   Caligiuri, Michael A ^b   Nervi, Clara ^c   Bloomfield, Clara D ^b   Marcucci, Guido ^b   Yu, Li ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b OHIO STATE UNIVERSITY   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 193A; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; EPIGENETICS; G1 PHASE CELL CYCLE CHECKPOINT; GENE SEQUENCE; GENE SILENCING; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; LEUKEMOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RNA ANALYSIS; SIGNAL TRANSDUCTION;

EID: 84872454123     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-07-444729     Document Type: Article

References (25)

1. Peterson LF, Boyapati A, Ahn EY, et al. Acute myeloid leukemia with the 8q22; 21q22 translocation: secondary mutational events and alternative t(8; 21) transcripts. Blood. 2007; 110(3): 799-805. (Pubitemid 47267414)
2. Gardini A, Cesaroni M, Luzi L, et al. AML1/ETO oncoprotein is directed to AML1 binding regions and colocalizes with AML1 and HEB on its targets. PLoS Genet. 2008; 4(11): e1000275.
3. Steffen B, Knop M, Bergholz U, et al. AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein. Blood. 2011; 117(16): 4328-4337.
4. Wang YY, Zhao LJ, Wu CF, et al. C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice. Proc Natl Acad Sci U S A. 2011; 108(6): 2450-2455.
5. Fazi F, Racanicchi S, Zardo G, et al. Epigenetic silencing of the myelopoiesis regulator microRNA- 223 by the AML1/ETO oncoprotein. Cancer Cell. 2007; 12(5): 457-466. (Pubitemid 350046404)
6. Ooi AG, Sahoo D, Adorno M,Wang Y,Weissman IL, Park CY. MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. Proc Natl Acad Sci U S A. 2010; 107(50): 21505-21510.
7. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004; 5(7): 522-531. (Pubitemid 38868508)
8. Garzon R, Marcucci G, Croce CM. Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov. 2010; 9(10): 775-789.
9. Liu S,Wu LC, Pang J, et al. Sp1/NFkappaB/HDAC/ miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell. 2010; 17(4): 333-347.
10. Chapuis N, Park S, Leotoing L, et al. IkappaB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia. Blood. 2010; 116(20): 4240-4250.
11. Fu CT, Zhu KY, Mi JQ, et al. An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation. Blood. 2010; 115(23): 4715-4724.
12. Jelovac D, Park BH. PTEN promoter silencing and Cowden syndrome: the role of epigenetic regulation of KILLIN. JAMA. 2010; 304(24): 2744-2745.
13. Bennett JM, Catovsky D, Daniel MT, et al. Proposed revised criteria for the classification of acute myeloid leukemia: a report of the French- American-British Cooperative Group. Ann Intern Med. 1985; 103(4): 620-625.
14. Duque-Afonso J, Yalcin A, Berg T, Abdelkarim M, Heidenreich O, Lubbert M. The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO. Oncogene. 2011; 30(27): 3062-3072.
15. Fazi F, Zardo G, Gelmetti V, et al. Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia. Blood. 2007; 109(10): 4432-4440. (Pubitemid 46743413)
16. Martinez Soria N, Tussiwand R, Ziegler P, Manz MG, Heidenreich O. Transient depletion of RUNX1/ RUNX1T1 by RNA interference delays tumour formation in vivo. Leukemia. 2009; 23(1): 188-190.
17. Yu L, Liu C, Vandeusen J, et al. Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumorsuppressor gene in human leukemia. Nat Genet. 2005; 37(3): 265-274. (Pubitemid 41716253)
18. Gao XN, Lin J, Li YH, et al. MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia. Oncogene. 2011; 30(31): 3416-3428.
19. Liu Y, Chen W, Gaudet J, et al. Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity. Cancer Cell. 2007; 11(6): 483-497. (Pubitemid 46856906)
20. Choudhary C, Olsen JV, Brandts C, et al. Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell. 2009; 36(2): 326-339.
21. Huarte M, Rinn JL. Large non-coding RNAs: missing links in cancer? Hum Mol Genet. 2010; 19(R2): R152-161.
22. Pichiorri F, Suh SS, Rocci A, et al. Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell. 2010; 18(4): 367-381.
23. Bueno MJ, Perez de Castro I, Gomez de Cedron M, et al. Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell. 2008; 13(6): 496-506. (Pubitemid 351763902)
24. Salmena L, Carracedo A, Pandolfi PP. Tenets of PTEN tumor suppression. Cell. 2008; 133(3): 403-414. (Pubitemid 351622014)
25. Chen J, Feilotter HE, Pare GC, et al. MicroRNA- 193b represses cell proliferation and regulates cyclin D1 in melanoma. Am J Pathol. 2010; 176(5): 2520-2529.