Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 33, Issue 3, 2013, Pages 755-766

  Velayudhan, Latha ^a,b   Proitsi, Petroula ^a   Westman, Eric ^c   Muehlboeck, J Sebastian ^c   Mecocci, Patrizia ^d   Vellas, Bruno ^e   Tsolaki, Magda ^f   Kłoszewska, Iwona ^g   Soininen, Hilkka ^h   Spenger, Christian ^c   Hodges, Angela ^a   Powell, John ^a   Lovestone, Simon ^a   Simmons, Andrew ^a  

^a King s College London   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF PERUGIA   (Italy)

^e UNIVERSITÉ DE TOULOUSE   (France)

^f ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^g MEDICAL UNIVERSITY OF LODZ   (Poland)

^h KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Alzheimer's disease; biomarker; cognitive decline; entorhinal cortex; hippocampus; whole brain volume

Indexed keywords

AGED; ALZHEIMER DISEASE; ALZHEIMER DISEASE ASSESSMENT SCALE COGNITIVE; ARTICLE; BRAIN REGION; BRAIN SIZE; CLINICAL DEMENTIA RATING; CLINICAL EVALUATION; COGNITION; CONTROLLED STUDY; DISEASE SEVERITY; ENTORHINAL CORTEX; FEMALE; FOLLOW UP; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTION; PRIORITY JOURNAL; RATING SCALE; THICKNESS;

EID: 84872434069     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-121408     Document Type: Article

References (74)

1. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M, Alzheimer's Disease, International (2005) Global prevalence of dementia: A Delphi consensus study. Lancet 366, 2112-2117. (Pubitemid 41797645)
2. Frank RA, GalaskoD, Hampel H, Hardy J, de Leon MJ, Mehta PD, Rogers J, Siemers E, Trojanowski JQ, National Institute on Aging Biological Markers Working Group (2003) Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease. Neurobiol Aging 24, 521-536. (Pubitemid 36519160)
3. Galasko D (2005) Biomarkers for Alzheimer's disease- clinical needs and application. J Alzheimers Dis 8, 339-346.
4. Fennema-Notestine C, McEvoy LK, Hagler DJ Jr, Jacobson MW, Dale AM, The Alzheimer's Disease Neuroimaging Initiative (2009) Structural neuroimaging in the detection and prognosis of pre-clinical and early AD. Behav Neurol 21, 3-12.
5. Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82, 239-259.
6. Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112, 389-404. (Pubitemid 44469160)
7. Jack CR Jr, Shiung MM, Gunter JL, O'Brien PC, Weigand SD, Knopman DS, Boeve BF, Ivnik RJ, Smith GE, Cha RH, Tangalos EG, Petersen RC (2004) Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD. Neurology 62, 591-600. (Pubitemid 38252801)
8. Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, Tanzi R, Jones K, Albert MS (2002) MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology 58, 1188-1196. (Pubitemid 34411862)
9. Varon D, LoewensteinDA, Potter E, GreigMT, Agron J, Shen Q, ZhaoW, Celeste Ramirez M, Santos I, BarkerW, Potter H, Duara R (2011) Minimal atrophy of the entorhinal cortex and hippocampus: Progression of cognitive impairment. Dement Geriatr Cogn Disord 31, 276-283.
10. McEvoy LK, Fennema-Notestine C, Roddey JC, Hagler DJ Jr, Holland D, Karow DS, Pung CJ, Brewer JB, Dale AM, Alzheimer's Disease Neuroimaging Initiative (2009) Alzheimer disease: Quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment. Radiology 251, 195-205.
11. Cardenas VA, Chao LL, Studholme C, Yaffe K, Miller BL, Madison C, Buckley ST, Mungas D, Schuff N, Weiner MW (2011) Brain atrophy associated with baseline and longitudinal measures of cognition. Neurobiol Aging 32, 572-580.
12. Mungas D, Jagust WJ, Reed BR, Kramer JH, Weiner MW, Schuff N, Norman D, Mack WJ, Willis L, Chui HC (2001) MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease. Neurology 57, 2229-2235. (Pubitemid 34016456)
13. Costafreda SG, Dinov ID, Tu Z, Shi Y, Liu CY, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Wahlund LO, Spenger C, Toga AW, Lovestone S, Simmons A (2011) Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment. Neuroimage 56, 212-219.
14. Westman E, Simmons A, Zhang Y, Muehlboeck JS, Tunnard C, Liu Y, Collins L, Evans A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Spenger C, Wahlund LO, AddNeuroMed consortium (2011) Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls. Neuroimage 54, 1178-1187.
15. Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund LO, Simmons A,Tunnard C, SobowT,Mecocci P, Tsolaki M,Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H, AddNeuroMed Consortium (2010) Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease. Neurobiol Aging 31, 1375-1385.
16. Westman E, Simmons A, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki MM, Kloszewska I, Soininen H, Weiner MW, Lovestone S, Spenger C,Wahlund LO (2011) AddNeuroMed and ADNI: Similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America. Neuroimage 58, 818-828.
17. Westman E, Cavallin L, Muehlboeck JS, Zhang Y, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Lovestone S, Simmons A,Wahlund LO (2011) Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's disease. PLoS One 6, e22506.
18. Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H, AddNeuroMed Consortium (2011) Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups - the AddNeuroMed study. Neurobiol Aging 32, 1198-1206.
19. Lovestone S, Francis P, Strandgaard K (2007) Biomarkers for disease modification trials-the innovative medicines initiative and AddNeuroMed. J Nutr Health Aging 11, 359-361. (Pubitemid 47121941)
20. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34, 939-944. (Pubitemid 14076461)
21. Folstein MF, Folstein SE, McHugh PR (1975) 'Mini-mental state': A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
22. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL (1982) A new clinical scale for the staging of dementia. Br J Psychiatry 140, 566-572. (Pubitemid 12124384)
23. Simmons A, Westman E, Muehlboeck S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Wahlund LO, Soininen H, Lovestone S, Evans A, Spenger C (2011) The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: Experience from the first 24 months. Int J Ger Psych 26, 75-82.
24. Thambisetty M, Simmons A,Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund LO, Westman E, Kinsey A, G?untert A, Proitsi P, Powell J, Causevic M, Killick R, Lunnon K, Lynham S, Broadstock M, Choudhry F, Howlett DR, Williams RJ, Sharp SI, Mitchelmore C, Tunnard C, Leung R, Foy C, O'Brien D, Breen G, Furney SJ, Ward M, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Hodges A, Murphy DG, Parkins S, Richardson JC, Resnick SM, Ferrucci L, Wong DF, Zhou Y, Muehlboeck S, Evans A, Francis PT, Spenger C, Lovestone S (2010) Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psych 67, 739-748.
25. Roth M, Tym E, Mountjoy CQ, Huppert FA, Hendrie H, Verma S, Goddard R (1986) CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry 149, 698-709. (Pubitemid 17205276)
26. Rosen WG, Mohs RC, Davis KL (1984) A new rating scale for Alzheimer's disease. Am J Psychiatry 141, 1356-1364.
27. Wenham PR, Price WH, Blandell G (1991) Apolipoprotein E genotyping by one-stage PCR. Lancet 337, 1158-1159.
28. Jack CR Jr, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ, Whitwell Jennifer L, Ward C, Dale AM, Felmlee JP, Gunter JL, Hill DL, Killiany R, Schuff N, Fox-Bosetti S, Lin C, Studholme C, DeCarli CS, Krueger G, Ward HA, Metzger GJ, Scott KT, Mallozzi R, Blezek D, Levy J, Debbins JP, Fleisher AS, Albert M, Green R, Bartzokis G, Glover G, Mugler J,WeinerMW(2008) The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods. J Magn Reson Imaging 27, 685-691. (Pubitemid 351508080)
29. Simmons A, Westman E, Muehlboeck S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Wahlund LO, Soininen H, Lovestone S, Evans A, Spenger C, AddNeuroMed Consortium (2009) MRI measures of Alzheimer's disease and the AddNeuroMed study. Ann N Y Acad Sci 1180, 47-55.
30. Segonne F, Dale AM, Busa E, Glessner M, Salat D, Hahn HK, Fischl B (2004) A hybrid approach to the skull stripping problem in MRI. Neuroimage 22, 1060-1075. (Pubitemid 38829195)
31. Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van derKouwe A, Killiany R,Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM (2002) Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain. Neuron 33, 341-355. (Pubitemid 34162530)
32. Fischl B, Salat DH, van der Kouwe AJ, Makris N, Segonne F, Quinn BT, Dale AM (2004) Sequence-independent segmentation of magnetic resonance images. Neuroimage 23(Suppl 1), S69-S84. (Pubitemid 39429376)
33. Sled JG, Zijdenbos AP, Evans AC (1998) A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 17, 87-97. (Pubitemid 128742012)
34. Fischl B, Liu A, Dale AM (2001) Automated manifold surgery: Constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging 20, 70-80. (Pubitemid 32293421)
35. Segonne F, Pacheco J, FischlB(2007) Geometrically accurate topology-correction of cortical surfaces using nonseparating loops. IEEE Trans Med Imaging 26, 518-529. (Pubitemid 46527332)
36. Dale AM, Fischl B, Sereno MI (1999) Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 9, 179-194. (Pubitemid 29369874)
37. Dale AM, Sereno MI (1993) Improved localization of cortical activity by combining EEG and MEG with MRI cortical surface reconstruction: A linear approach. J Cogn Neurosci 5, 162-176. (Pubitemid 23123842)
38. Fischl B, Dale AM (2000) Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci U S A 97, 11050-11055.
39. Fischl B, Sereno MI, Tootell RB, Dale AM (1999) Highresolution intersubject averaging and a coordinate system for the cortical surface. Hum Brain Mapp 8, 272-284.
40. Desikan RS, S'egonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Hyman BT, Albert MS, Killiany RJ (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31, 968-980. (Pubitemid 44183792)
41. Fischl B, van der Kouwe A, Destrieux C, Halgren E, Segonne F, Salat DH, Busa E, Seidman LJ, Goldstein J, Kennedy D, Caviness V, Makris N, Rosen B, Dale AM (2004) Automatically parcellating the human cerebral cortex. Cereb Cortex 14, 11-22. (Pubitemid 38018050)
42. Westman E, Wahlund LO, Foy C, Poppe M, Cooper A, MurphyD, Spenger C, Lovestone S, SimmonsA(2010) Combining MRI and MRS to distinguish between Alzheimer's disease and healthy controls. J Alzheimers Dis 22, 171-181.
43. Liu Y, Paajanen T, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H, AddNeuroMed Consortium (2010) Effect of APOE epsilon4 allele on cortical thicknesses and volumes: The AddNeuroMed study. J Alzheimers Dis 21, 947-966.
44. Liu Y, Paajanen T, Westman E, Zhang Y, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H, AddNeuroMed Consortium (2010) APOE epsilon2 allele is associated with larger regional cortical thicknesses and volumes. Dement Geriatr Cogn Disord 30, 229-237.
45. Westman E, Aguilar C, Muehlboeck J-S, Simmons A (2012) Regional magnetic resonance imaging measures for multivariate analysis in Alzheimer's disease and mild cognitive impairment. Brain Topography, doi: 10.1007/s10548-012-0246-x [Epub ahead of print]
46. Karow DS, McEvoy LK, Fennema-Notestine C, Hagler DJ Jr, Jennings RG, Brewer JB, Hoh CK, Dale AM, Alzheimer's Disease Neuroimaging Initiative (2010) Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease. Radiology 256, 932-942.
47. Burggren AC, Renner B, Jones M, Donix M, Suthana NA, Martin-Harris L, Ercoli LM,Miller KJ, Siddarth P, SmallGW, Bookheimer SY (2011) Thickness in entorhinal and subicular cortex predicts episodic memory decline in mild cognitive impairment. Int J Alzheimers Dis 15, 956053.
48. Du AT, Schuff N, Kramer JH, Ganzer S, Zhu XP, Jagust WJ, Miller BL, Reed BR, Mungas D, Yaffe K, Chui HC, Weiner MW (2004) Higher atrophy rate of entorhinal cortex than hippocampus in AD. Neurology 62, 422-427. (Pubitemid 38200854)
49. Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J,Wahlund LO, Kloszewska I, Mecocci P, Soininen H, Tsolaki M,Vellas B, Spenger C, Lathrop M, Shen L, Kim S, Saykin AJ,WeinerMW, Lovestone S; Alzheimer's Disease Neuroimaging Initiative; AddNeuroMed Consortium (2011) Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol Psychiatry 16, 1130-1138.
50. Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK et al. Parikshak N, Toga AW, Jack CR Jr, Schuff N, Weiner MW, Thompson PM, Alzheimer's Disease Neuroimaging Initiative (2009) Automated mapping of hippocampal atrophy in 1-year repeatMRIdata from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Neuroimage 45(1 Suppl), S3-S15.
51. Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Liu E, Morris JC, Petersen RC, Saykin AJ, Schmidt ME, Shaw L, Siuciak JA, Soares H, Toga AW, Trojanowski JQ, Alzheimer's Disease Neuroimaging Initiative (2011) The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception. Alzheimers Dement 8(1 Suppl), S1-S68.
52. Ridha BH, Anderson VM, Barnes J, Boyes RG, Price SL, Rossor MN, Whitwell JL, Jenkins L, Black RS, Grundman M, Fox NC (2008) Volumetric MRI and cognitive measures in Alzheimer disease: Comparison of markers of progression. J Neurol 255, 567-574.
53. Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR Jr, Schuff N, Weiner MW, Thompson PM, Alzheimer's Disease Neuroimaging Initiative (2009) Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Hum Brain Mapp 30, 2766-2788.
54. Kovacevic S, Rafii MS, Brewer JB, Alzheimer's Disease Neuroimaging Initiative (2009) High throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment. Alzheimer Dis Assoc Disorder 23, 139-145.
55. Sluimer JD, van der Flier WM, Karas GB, Fox NC, Scheltens P, Barkhof F, Vrenken H (2008) Whole-brain atrophy rate and cognitive decline: Longitudinal MR study of memory clinic patients. Radiology 248, 590-598.
56. Squire LR, Zola-Morgan S (1991) The medial temporal lobe memory system. Science 253, 1380-1386. (Pubitemid 21917285)
57. Stranahan AM,Mattson MP (2010) Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer's disease. Neural Plast 2010, 108190.
58. Galasko DR, Gould RL, Abramson IS, Salmon DP (2000) Measuring cognitive change in a cohort of patients with Alzheimer's disease. Stat Med 19, 1421-1432. (Pubitemid 30346235)
59. Suh GH, Ju YS,Yeon BK, ShahA(2004)Alongitudinal study of Alzheimer's disease: Rates of cognitive and functional decline. Int J Geriatr Psychiatry 19, 817-824.
60. Bobinski M, de Leon MJ, Convit A, De Santi S, Wegiel J, Tarshish CY, Saint Louis LA, Wisniewski HM (1999) MRI of entorhinal cortex in mild Alzheimer's disease. Lancet 353, 38-40. (Pubitemid 29037707)
61. Juottonen K, Laakso MP, Insausti R, Lehtovirta M, Pitk?anen A, Partanen K, Soininen H (1998) Volumes of the entorhinal and perirhinal cortices in Alzheimer's disease. Neurobiol Aging 19, 15-22. (Pubitemid 28169839)
62. Dickerson BC, Goncharova I, Sullivan MP, Forchetti C, Wilson RS, Bennett DA, Beckett LA, deToledo-Morrell L (2001) MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease. Neurobiol Aging 22, 747-754. (Pubitemid 33055614)
63. Du AT, Schuff N, Amend D, Laakso MP, Hsu YY, Jagust WJ, Yaffe K, Kramer JH, Reed B, Norman D, Chui HC, Weiner MW (2001) Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease. J Neurol Neurosurg Psychiatry 71, 441-447. (Pubitemid 32906865)
64. Jack CR Jr (2011) Alliance for Aging Research AD Biomarkers Work Group: Structural MRI. Neurobiol Aging 32(Suppl 1), S48-S57.
65. Braak H, Braak E (1995) Staging of Alzheimer's diseaserelated neurofibrillary changes. Neurobiol Aging 16, 271-278, discussion 278-284.
66. Risacher SL, Shen L, West JD, Kim S, McDonald BC, Beckett LA, Harvey DJ, Jack CR, Weiner MW, Saykin AJ, Alzheimer's Disease Neuroimaging Initiative (ADNI) (2010) Longitudinal MRI atrophy biomarkers: Relationship to conversion in the ADNI cohort. Neurobiol Aging 31, 1401-1418.
67. Thompson WK, Hallmayer J, O'Hara R, Alzheimer's Disease Neuroimaging Initiative (2011) Design considerations for characterizing psychiatric trajectories across the lifespan: Application to effects of APOE-4 on cerebral cortical thickness in Alzheimer's disease. Am J Psychiatry 168, 894-903.
68. Wang PN, Liu HC, Lirng JF, Lin KN, Wu ZA (2009) Accelerated hippocampal atrophy rates in stable and progressive amnestic mild cognitive impairment. Psychiatry Res 171, 221-231.
69. Vemuri P, Wiste HJ, Weigand SD, Shaw LM, Trojanowski JQ, Weiner MW, Knopman DS, Petersen RC, Jack CR Jr, Alzheimer's Disease Neuroimaging Initiative (2009) MRI and CSF biomarkers in normal, MCI, and AD subjects: Predicting future clinical change. Neurology 73, 294-301.
70. Vemuri P, Wiste HJ, Weigand SD, Shaw LM, Trojanowski JQ, Weiner MW, Knopman DS, Petersen RC, Jack CR Jr, Alzheimer's Disease Neuroimaging Initiative (2009)MRIand CSF biomarkers in normal, MCI, andADsubjects: Diagnostic discrimination and cognitive correlations. Neurology 73, 287-293.
71. Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ (2010) Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 9, 119-128.
72. Westman E, Wahlund LO, Foy C, Poppe M, Cooper A, Murphy D, Spenger C, Lovestone S, Simmons A (2011) Magnetic resonance imaging and magnetic resonance spectroscopy for detection of early Alzheimer's disease. J Alzheimer's Disease 26, 307-319.
73. Thambisetty M, Simmons A, Hye A, Campbell J, Zhang Y, Wahlund L-O, Kinsey A, Causevic M, Killick R, Broadstock M, Tunnard C, Leung R, Foy C, O'Brien D, Prinz T, Ward M, Kloszewska I, Mecozzi P, Soininen H, Tsolaki M, Vellas B, Murphy D, Parkins S, Muehlboeck S, Evans A, Francis P, Spenger C, Lovestone S for the AddNeuroMed consortium (2011) Plasma biomarkers of brain atrophy in Alzheimer's disease. PLoS One 6, e28527.
74. Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, Lunnon K, Soininen H, Klosweska I, Tsolaki M, Vellas B, Mecocci P, Lovestone S, Newhouse S, Dobson R (2012) Plasma based markers of [11C]-PiB brain amyloid burden. PLoS One 7, e44260.