Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: Comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor

Clinical Science

Volumn 124, Issue 8, 2013, Pages 529-541

  Thomas, Candice M ^a   Yong, Qian Chen ^a   Seqqat, Rachid ^a,b   Chandel, Niketa ^a   Feldman, David L ^c   Baker, Kenneth M ^a   Kumar, Rajesh ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b UNIVERSIDAD DE LAS FUERZAS ARMADAS ESPE   (Ecuador)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Angiotensin receptor blocker; Angiotensin converting enzyme; Diabetic cardiomyopathy; Intracrine; Prorenin receptor; Renin angiotensin system (RAS)

Indexed keywords

ALISKIREN; BENAZEPRILAT; INSULIN; RENIN; STREPTOZOCIN; VALSARTAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DIASTOLIC BLOOD PRESSURE; HEART FUNCTION; HYPERGLYCEMIA; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STREPTOZOCIN DIABETES; SYSTOLIC BLOOD PRESSURE;

AMIDES; ANGIOTENSIN RECEPTOR ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BENZAZEPINES; BLOOD PRESSURE; DIABETES MELLITUS, EXPERIMENTAL; FUMARATES; HEART; HUMANS; MALE; MICE; MICE, INBRED C57BL; MYOCARDIUM; OXIDATIVE STRESS; RECEPTORS, CELL SURFACE; RENIN; TETRAZOLES; VALINE;

EID: 84872423393     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20120448     Document Type: Article

References (14)

1. Hollenberg, N. K., Fisher, N. D., Nussberger, J., Moukarbel, G. V., Barkoudah, E. and Danser, A. H. (2011) Renal responses to three types of renin-angiotensin system blockers in patients with diabetes mellitus on a high-salt diet: a need for higher doses in diabetic patients? J. Hypertens. 29, 2454-2461
2. Fraune, C., Lange, S., Krebs, C., Holzel, A., Baucke, J., Divac, N., Schwedhelm, E., Streichert, T., Velden, J., Garrelds, I. M. et al. (2012) AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease. Am. J. Physiol. Renal Physiol. 303, F1037-1048
3. van Esch, J. H., Moltzer, E., van Veghel, R., Garrelds, I. M., Leijten, F., Bouhuizen, A. M. and Danser, A. H. (2010) Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats. J. Hypertens. 28, 2145-2155
4. Baker, K. M., Chernin, M. I., Schreiber, T., Sanghi, S., Haiderzaidi, S., Booz, G. W., Dostal, D. E. and Kumar, R. (2004) Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy. Regul. Pept. 120, 5-13
5. Schnell, C. R. and Wood, J. M. (1993) Measurement of blood pressure and heart rate by telemetry in conscious, unrestrained marmosets. Am. J. Physiol. Heart Circ. Physiol. 264, H1509-H1516
6. Tomono, Y., Iwai, M., Inaba, S., Mogi, M. and Horiuchi, M. (2008) Blockade of AT1 receptor improves adipocyte differentiation in atherosclerotic and diabetic models. Am. J. Hypertens. 21, 206-212
7. Lu, H., Rateri, D. L., Feldman, D. L., Jr, R. J., Fukamizu, A., Ishida, J., Oesterling, E. G., Cassis, L. A. and Daugherty, A. (2008) Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J. Clin. Invest. 118, 984-993
8. Singh, V. P., Le, B., Bhat, V. B., Baker, K. M. and Kumar, R. (2007) High glucose induced regulation of intracellular angiotensin II synthesis and nuclear redistribution in cardiac myocytes. Am. J. Physiol. Heart Circ. Physiol. 293, H939-H948
9. Singh, V. P., Le, B., Khode, R., Baker, K. M. and Kumar, R. (2008) Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis. Diabetes 57, 3297-3306
10. Mazzolai, L., Pedrazzini, T., Nicoud, F., Gabbiani, G., Brunner, H. R. and Nussberger, J. (2000) Increased cardiac angiotensin II levels induce right and left ventricular hypertrophy in normotensive mice. Hypertension 35, 985-991
11. Singh, V. P., Baker, K. M. and Kumar, R. (2008) Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production. Am. J. Physiol. Heart Circ. Physiol. 294, H1675-1684
12. Hilgers, K. F., Hartner, A., Porst, M., Veelken, R. and Mann, J. F. (2001) Angiotensin II type 1 receptor blockade prevents lethal malignant hypertension: relation to kidney inflammation. Circulation 104, 1436-1440
13. Ledingham, J. M. and Laverty, R. (1996) Remodelling of resistance arteries in genetically hypertensive rats by treatment with valsartan, an angiotensin II receptor antagonist. Clin. Exp. Pharmacol. Physiol. 23, 576-578
14. Wu, L., Iwai, M., Nakagami, H., Li, Z., Chen, R., Suzuki, J., Akishita, M., de Gasparo, M. and Horiuchi, M. (2001) Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury. Circulation 104, 2716-2721