In-depth proteomic analysis of the human sperm reveals complex protein compositions

Journal of Proteomics

Volumn 79, Issue , 2013, Pages 114-122

  Wang, Gaigai ^a   Guo, Yueshuai ^a   Zhou, Tao ^a   Shi, Xiaodan ^a   Yu, Jun ^a   Yang, Ye ^a   Wu, Yibo ^a   Wang, Jing ^a   Liu, Mingxi ^a   Chen, Xin ^a   Tu, Wenjiao ^a   Zeng, Yan ^a   Jiang, Min ^a   Li, Suying ^a   Zhang, Pan ^a   Zhou, Quan ^a   Zheng, Bo ^a   Yu, Chunmei ^a   Zhou, Zuomin ^a   Guo, Xuejiang ^a   Sha, Jiahao ^a   more..

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Drug; Human; Mass spectrometry; Proteome; Signaling pathway; Sperm

Indexed keywords

CALCIUM; INSULIN; INTERLEUKIN 6; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BIOINFORMATICS; DROSOPHILA; HUMAN; IMMUNOFLUORESCENCE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; SEMEN ANALYSIS; SIGNAL TRANSDUCTION; SPERM; SPERMATOZOON MOTILITY;

ADULT; GENITALIA, MALE; HUMANS; MALE; MASS SPECTROMETRY; PROTEOME; PROTEOMICS; SPERMATOZOA;

EID: 84872418742     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2012.12.008     Document Type: Article

References (49)

1. Ostermeier G.C., Dix D.J., Miller D., Khatri P., Krawetz S.A. Spermatozoal RNA profiles of normal fertile men. Lancet 2002, 360:772-777.
2. Evaluation of the azoospermic male. Fertil Steril 2008, 90:S74-S77.
3. Martinez-Heredia J., Estanyol J.M., Ballesca J.L., Oliva R. Proteomic identification of human sperm proteins. Proteomics 2006, 6:4356-4369.
4. Ostermeier G.C., Miller D., Huntriss J.D., Diamond M.P., Krawetz S.A. Reproductive biology: delivering spermatozoan RNA to the oocyte. Nature 2004, 429:154.
5. Ankel-Simons F., Cummins J.M. Misconceptions about mitochondria and mammalian fertilization: implications for theories on human evolution. Proc Natl Acad Sci U S A 1996, 93:13859-13863.
6. Loppin B., Lepetit D., Dorus S., Couble P., Karr T.L. Origin and neofunctionalization of a Drosophila paternal effect gene essential for zygote viability. Curr Biol 2005, 15:87-93.
7. Paik Y.K., Jeong S.K., Omenn G.S., Uhlen M., Hanash S., Cho S.Y., et al. The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome. Nat Biotechnol 2012, 30:221-223.
8. Dezso Z., Nikolsky Y., Sviridov E., Shi W., Serebriyskaya T., Dosymbekov D., et al. A comprehensive functional analysis of tissue specificity of human gene expression. BMC Biol 2008, 6:49.
9. Baker M.A., Reeves G., Hetherington L., Muller J., Baur I., Aitken R.J. Identification of gene products present in Triton X-100 soluble and insoluble fractions of human spermatozoa lysates using LC-MS/MS analysis. Proteomics Clin Appl 2007, 1:524-532.
10. Johnston D.S., Wooters J., Kopf G.S., Qiu Y., Roberts K.P. Analysis of the human sperm proteome. Ann N Y Acad Sci 2005, 1061:190-202.
11. Baker M.A., Hetherington L., Reeves G.M., Aitken R.J. The mouse sperm proteome characterized via IPG strip prefractionation and LC-MS/MS identification. Proteomics 2008, 8:1720-1730.
12. Baker M.A., Hetherington L., Reeves G., Muller J., Aitken R.J. The rat sperm proteome characterized via IPG strip prefractionation and LC-MS/MS identification. Proteomics 2008, 8:2312-2321.
13. Gandini L., Lenzi A., Lombardo F., Pacifici R., Dondero F. Immature germ cell separation using a modified discontinuous Percoll gradient technique in human semen. Hum Reprod 1999, 14:1022-1027.
14. Zhao C., Huo R., Wang F.Q., Lin M., Zhou Z.M., Sha J.H. Identification of several proteins involved in regulation of sperm motility by proteomic analysis. Fertil Steril 2007, 87:436-438.
15. Cox J., Neuhauser N., Michalski A., Scheltema R.A., Olsen J.V., Mann M. Andromeda: a peptide search engine integrated into the MaxQuant environment. J Proteome Res 2011, 10:1794-1805.
16. Huang da W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009, 4:44-57.
17. Zhang B., Kirov S., Snoddy J. WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res 2005, 33:W741-W748.
18. Gherman A., Davis E.E., Katsanis N. The ciliary proteome database: an integrated community resource for the genetic and functional dissection of cilia. Nat Genet 2006, 38:961-962.
19. Wishart D.S., Knox C., Guo A.C., Cheng D., Shrivastava S., Tzur D., et al. DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res 2008, 36:D901-D906.
20. Wang L., Chen W., Zhao C., Huo R., Guo X.J., Lin M., et al. The role of ezrin-associated protein network in human sperm capacitation. Asian J Androl 2010, 12:667-676.
21. de Lamirande E., Gagnon C. The extracellular signal-regulated kinase (ERK) pathway is involved in human sperm function and modulated by the superoxide anion. Mol Hum Reprod 2002, 8:124-135.
22. de Mateo S., Castillo J., Estanyol J.M., Ballesca J.L., Oliva R. Proteomic characterization of the human sperm nucleus. Proteomics 2011, 11:2714-2726.
23. Yoon S.Y., Jellerette T., Salicioni A.M., Lee H.C., Yoo M.S., Coward K., et al. Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development. J Clin Invest 2008, 118:3671-3681.
24. Lefievre L., de Lamirande E., Gagnon C. Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa. Biol Reprod 2002, 67:423-430.
25. Fukami K., Nakao K., Inoue T., Kataoka Y., Kurokawa M., Fissore R.A., et al. Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction. Science 2001, 292:920-923.
26. Strunker T., Goodwin N., Brenker C., Kashikar N.D., Weyand I., Seifert R., et al. The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature 2011, 471:382-386.
27. Luconi M., Barni T., Vannelli G.B., Krausz C., Marra F., Benedetti P.A., et al. Extracellular signal-regulated kinases modulate capacitation of human spermatozoa. Biol Reprod 1998, 58:1476-1489.
28. Brener E., Rubinstein S., Cohen G., Shternall K., Rivlin J., Breitbart H. Remodeling of the actin cytoskeleton during mammalian sperm capacitation and acrosome reaction. Biol Reprod 2003, 68:837-845.
29. Gur Y., Breitbart H. Mammalian sperm translate nuclear-encoded proteins by mitochondrial-type ribosomes. Genes Dev 2006, 20:411-416.
30. Dorus S., Busby S.A., Gerike U., Shabanowitz J., Hunt D.F., Karr T.L. Genomic and functional evolution of the Drosophila melanogaster sperm proteome. Nat Genet 2006, 38:1440-1445.
31. Wasbrough E.R., Dorus S., Hester S., Howard-Murkin J., Lilley K., Wilkin E., et al. The Drosophila melanogaster sperm proteome-II (DmSP-II). J Proteomics 2010, 73:2171-2185.
32. Castrillon D.H., Gonczy P., Alexander S., Rawson R., Eberhart C.G., Viswanathan S., et al. Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics 1993, 135:489-505.
33. Karr T.L. Fruit flies and the sperm proteome. Hum Mol Genet 2007, 16. (Spec No. 2:R124-33).
34. Goldberg E., Eddy E.M., Duan C., Odet F. LDHC: the ultimate testis-specific gene. J Androl 2010, 31:86-94.
35. Kuravsky M.L., Aleshin V.V., Frishman D., Muronetz V.I. Testis-specific glyceraldehyde-3-phosphate dehydrogenase: origin and evolution. BMC Evol Biol 2011, 11:160.
36. Naz R.K., Kaplan P. Interleukin-6 enhances the fertilizing capacity of human sperm by increasing capacitation and acrosome reaction. J Androl 1994, 15:228-233.
37. Almog T., Lazar S., Reiss N., Etkovitz N., Milch E., Rahamim N., et al. Identification of extracellular signal-regulated kinase 1/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality. J Biol Chem 2008, 283:14479-14489.
38. Lampiao F., du Plessis S.S. TNF-alpha and IL-6 affect human sperm function by elevating nitric oxide production. Reprod Biomed Online 2008, 17:628-631.
39. Perdichizzi A., Nicoletti F., La Vignera S., Barone N., D'Agata R., Vicari E., et al. Effects of tumour necrosis factor-alpha on human sperm motility and apoptosis. J Clin Immunol 2007, 27:152-162.
40. Lampiao F., du Plessis S.S. Insulin and leptin enhance human sperm motility, acrosome reaction and nitric oxide production. Asian J Androl 2008, 10:799-807.
41. Breitbart H., Etkovitz N. Role and regulation of EGFR in actin remodeling in sperm capacitation and the acrosome reaction. Asian J Androl 2010, 13:106-110.
42. Naz R.K., Kumar R. Transforming growth factor beta 1 enhances expression of 50kDa protein related to 2'-5' oligoadenylate synthetase in human sperm cells. J Cell Physiol 1991, 146:156-163.
43. von Wolff M., Nowak O., Pinheiro R.M., Strowitzki T. Seminal plasma-immunomodulatory potential in men with normal and abnormal sperm count. Eur J Obstet Gynecol Reprod Biol 2007, 134:73-78.
44. Lieberman J.A., Moscicki A.B., Sumerel J.L., Ma Y., Scott M.E. Determination of cytokine protein levels in cervical mucus samples from young women by a multiplex immunoassay method and assessment of correlates. Clin Vaccine Immunol 2008, 15:49-54.
45. 125I]TGF beta-binding sites. J Clin Endocrinol Metab 1994, 79:1177-1184.
46. Krege J.H., John S.W., Langenbach L.L., Hodgin J.B., Hagaman J.R., Bachman E.S., et al. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 1995, 375:146-148.
47. Kondoh G., Tojo H., Nakatani Y., Komazawa N., Murata C., Yamagata K., et al. Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med 2005, 11:160-166.
48. Nixon B., Bielanowicz A., Anderson A.L., Walsh A., Hall T., McCloghry A., et al. Elucidation of the signaling pathways that underpin capacitation-associated surface phosphotyrosine expression in mouse spermatozoa. J Cell Physiol 2010, 224:71-83.
49. White R.M., Cech J., Ratanasirintrawoot S., Lin C.Y., Rahl P.B., Burke C.J., et al. DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature 2011, 471:518-522.