메뉴 건너뛰기




Volumn 115, Issue 2, 2013, Pages 100-112

Cytotoxicity induced by exposure to natural and synthetic tremolite asbestos: An in vitro pilot study

Author keywords

A549 cells; Cytotoxicity; Immunohistochemistry; Mineralogical characterization; Natural tremolite asbestos; Phallodin; Synthetic tremolite asbestos

Indexed keywords

ACTIN; ASBESTOS; BETA CATENIN; CADHERIN; CROCIDOLITE; F ACTIN; MINERAL FIBER; NATURAL TREMOLITE ASBESTOS; PROTEIN CDC42; SYNTHETIC TREMOLITE ASBESTOS; TREMOLITE; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 84872416611     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2012.04.004     Document Type: Article
Times cited : (34)

References (54)
  • 1
    • 54449102136 scopus 로고    scopus 로고
    • A review of carcinogenicity studies of asbestos and nonasbestos tremolite and other amphiboles
    • Addison J., McConnell E.E. A review of carcinogenicity studies of asbestos and nonasbestos tremolite and other amphiboles. Regul Toxicol Pharmacol 2008, 52:S187-S199.
    • (2008) Regul Toxicol Pharmacol , vol.52
    • Addison, J.1    McConnell, E.E.2
  • 4
    • 34548633859 scopus 로고    scopus 로고
    • Mitochondrial changes induced by natural and synthetic asbestos fibers: studies on isolated mitochondria
    • Bergamini C., Fato R., Biagini G., Pugnaloni A., Giantomassi F., Foresti E., et al. Mitochondrial changes induced by natural and synthetic asbestos fibers: studies on isolated mitochondria. Cell Mol Biol (Noisy-le-grand) 2007, 52(Suppl.):OL905-OL913.
    • (2007) Cell Mol Biol (Noisy-le-grand) , vol.52 , Issue.SUPPL.
    • Bergamini, C.1    Fato, R.2    Biagini, G.3    Pugnaloni, A.4    Giantomassi, F.5    Foresti, E.6
  • 7
    • 31344474845 scopus 로고    scopus 로고
    • Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood
    • Bremnes R.M., Camps C., Sirera R. Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer 2006, 51:143-158.
    • (2006) Lung Cancer , vol.51 , pp. 143-158
    • Bremnes, R.M.1    Camps, C.2    Sirera, R.3
  • 9
    • 79959226692 scopus 로고    scopus 로고
    • Applying definitions of 'asbestos'to environmental and 'low-dose'exposure levels and health effects, particularly malignant mesothelioma
    • Case1 W.B., Abraham J.L., Meeker G., Pooley F.D., Pinkerton K.E. Applying definitions of 'asbestos' to environmental and Pooley F.D.,'low-dose'exposure levels and health effects, particularly malignant mesothelioma. J Toxicol Environ Health B 2011, 14:3-39.
    • (2011) J Toxicol Environ Health B , vol.14 , pp. 3-39
    • Case1, W.B.1    Abraham, J.L.2    Meeker, G.3    Pooley, F.D.4    Pinkerton, K.E.5
  • 10
    • 0023974388 scopus 로고
    • Chrysotile, tremolite, and malignant mesothelioma in man
    • Churg A. Chrysotile, tremolite, and malignant mesothelioma in man. Chest 1988, 93:621-628.
    • (1988) Chest , vol.93 , pp. 621-628
    • Churg, A.1
  • 11
    • 0028120358 scopus 로고
    • Fiber burden and patterns of asbestos-related disease in workers with heavy mixed amosite and chrysotile exposure
    • Churg A., Vedal S. Fiber burden and patterns of asbestos-related disease in workers with heavy mixed amosite and chrysotile exposure. Am J Respir Crit Care Med 1994, 150:663-669.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 663-669
    • Churg, A.1    Vedal, S.2
  • 12
    • 0026408972 scopus 로고
    • Variations in the carcinogenicity of tremolite dust samples of differing morphology
    • Davis J.M., Addison J., McIntosh C., Miller B.G., Niven K. Variations in the carcinogenicity of tremolite dust samples of differing morphology. Ann N Y Acad Sci 1991, 643:473-490.
    • (1991) Ann N Y Acad Sci , vol.643 , pp. 473-490
    • Davis, J.M.1    Addison, J.2    McIntosh, C.3    Miller, B.G.4    Niven, K.5
  • 13
    • 46649102647 scopus 로고    scopus 로고
    • Erionite series minerals: mineralogical and carcinogenic properties
    • Dogan A.U., Dogan M., Hoskins J.A. Erionite series minerals: mineralogical and carcinogenic properties. Environ Geochem Health 2008, 30:367-381.
    • (2008) Environ Geochem Health , vol.30 , pp. 367-381
    • Dogan, A.U.1    Dogan, M.2    Hoskins, J.A.3
  • 14
    • 77952317021 scopus 로고    scopus 로고
    • Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma
    • Donaldson K., Murphy F.A., Duffin R., Poland C.A. Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol 2010, 22:7-19.
    • (2010) Part Fibre Toxicol , vol.22 , pp. 7-19
    • Donaldson, K.1    Murphy, F.A.2    Duffin, R.3    Poland, C.A.4
  • 15
    • 60749100678 scopus 로고    scopus 로고
    • The effect of weathering on ecopersistence, reactivity, and potential toxicity of naturally occurring asbestos and asbestiform minerals
    • Enrico Favero-Longo S., Turci F., Tomatis M., Compagnoni R., Piervittori R., Fubini B. The effect of weathering on ecopersistence, reactivity, and potential toxicity of naturally occurring asbestos and asbestiform minerals. J Toxicol Environ Health A 2009, 72:305-314.
    • (2009) J Toxicol Environ Health A , vol.72 , pp. 305-314
    • Enrico Favero-Longo, S.1    Turci, F.2    Tomatis, M.3    Compagnoni, R.4    Piervittori, R.5    Fubini, B.6
  • 16
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature 2002, 420(6916):629-635.
    • (2002) Nature , vol.420 , Issue.6916 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 17
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara N., Henzel W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989, 161:851-858.
    • (1989) Biochem Biophys Res Commun , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 18
    • 77957935560 scopus 로고    scopus 로고
    • Physico-chemical features of engineered nanoparticles relevant to their toxicity
    • Fubini B., Ghiazza M., Fenoglio I. Physico-chemical features of engineered nanoparticles relevant to their toxicity. Nanotoxicology 2010, 4:347-363.
    • (2010) Nanotoxicology , vol.4 , pp. 347-363
    • Fubini, B.1    Ghiazza, M.2    Fenoglio, I.3
  • 19
    • 35648950557 scopus 로고    scopus 로고
    • Immunohistochemical comparison of beta-catenin expression by human normal epidermis and epidermal tumors
    • Fukumaru K., Yoshii N., Kanzaki T., Kanekura T. Immunohistochemical comparison of beta-catenin expression by human normal epidermis and epidermal tumors. J Dermatol 2007, 34:746-753.
    • (2007) J Dermatol , vol.34 , pp. 746-753
    • Fukumaru, K.1    Yoshii, N.2    Kanzaki, T.3    Kanekura, T.4
  • 20
    • 33749037156 scopus 로고    scopus 로고
    • The ARP2/3 complex: an actin nucleator comes of age
    • Goley E.D., Welch M.D. The ARP2/3 complex: an actin nucleator comes of age. Nat Rev Mol Cell Biol 2006, 7:13-26.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 13-26
    • Goley, E.D.1    Welch, M.D.2
  • 21
    • 0031919717 scopus 로고    scopus 로고
    • Environmental exposure to crocidolite and mesothelioma. Exposure-response relationships
    • Hansen J., de Klerk N.H., Musk A.W., Hobbs M.S.T. Environmental exposure to crocidolite and mesothelioma. Exposure-response relationships. Am J Respir Crit Care Med 1998, 157:69-75.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 69-75
    • Hansen, J.1    de Klerk, N.H.2    Musk, A.W.3    Hobbs, M.S.T.4
  • 22
    • 50149083752 scopus 로고    scopus 로고
    • Mammalian Rho GTPases: new insights into their functions from in vivo studies
    • Heasman S.J., Ridley A.J. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 2008, 9:690-701.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 690-701
    • Heasman, S.J.1    Ridley, A.J.2
  • 23
    • 34147093740 scopus 로고    scopus 로고
    • Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling
    • Herzig M., Savarese F., Novatchkova M., Semb H., Christofori G. Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling. Oncogene 2007, 26:2290-2298.
    • (2007) Oncogene , vol.26 , pp. 2290-2298
    • Herzig, M.1    Savarese, F.2    Novatchkova, M.3    Semb, H.4    Christofori, G.5
  • 24
    • 77149177975 scopus 로고    scopus 로고
    • Utilization of gene profiling and proteomics to determine mineral pathogenicity in a human mesothelial cell line (LP9/TERT-1)
    • Hillegass J.M., Shukla A., MacPherson M.B., Bond J.P., Steele C., Mossman B.T. Utilization of gene profiling and proteomics to determine mineral pathogenicity in a human mesothelial cell line (LP9/TERT-1). J Toxicol Environ Health A 2010, 73:423-436.
    • (2010) J Toxicol Environ Health A , vol.73 , pp. 423-436
    • Hillegass, J.M.1    Shukla, A.2    MacPherson, M.B.3    Bond, J.P.4    Steele, C.5    Mossman, B.T.6
  • 25
    • 62349106819 scopus 로고    scopus 로고
    • Asbestos-induced lung diseases: an update
    • Kamp D.W. Asbestos-induced lung diseases: an update. Transl Res 2009, 153:143-152.
    • (2009) Transl Res , vol.153 , pp. 143-152
    • Kamp, D.W.1
  • 26
    • 66749110407 scopus 로고    scopus 로고
    • Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines
    • Lanone S., Rogerieux F., Geys J., Dupont A., Maillot-Marechal E., Boczkowski J., et al. Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines. Part Fibre Toxicol 2009, 30:6-14.
    • (2009) Part Fibre Toxicol , vol.30 , pp. 6-14
    • Lanone, S.1    Rogerieux, F.2    Geys, J.3    Dupont, A.4    Maillot-Marechal, E.5    Boczkowski, J.6
  • 27
    • 78649859750 scopus 로고    scopus 로고
    • Regulation of lung cancer cell migration and invasion by reactive oxygen species and Caveolin-1
    • Luanpitpong S., Talbott S.J., Rojanasakul Y., Nimmannit U., Pongrakhananon V., Wang L., et al. Regulation of lung cancer cell migration and invasion by reactive oxygen species and Caveolin-1. J Biol Chem 2010, 285:38832-38840.
    • (2010) J Biol Chem , vol.285 , pp. 38832-38840
    • Luanpitpong, S.1    Talbott, S.J.2    Rojanasakul, Y.3    Nimmannit, U.4    Pongrakhananon, V.5    Wang, L.6
  • 28
    • 78649453104 scopus 로고    scopus 로고
    • Epidemiology of malignant mesothelioma - an outline
    • McDonald J.C. Epidemiology of malignant mesothelioma - an outline. Ann Occup Hyg 2010, 54:851-857.
    • (2010) Ann Occup Hyg , vol.54 , pp. 851-857
    • McDonald, J.C.1
  • 29
    • 0036877222 scopus 로고    scopus 로고
    • Mortality among patients with pleural and peritoneal tumors in Alta Valle di Susa
    • Mirabelli D., Cadum E. Mortality among patients with pleural and peritoneal tumors in Alta Valle di Susa. Epidemiol Prev 2002, 26:284-286.
    • (2002) Epidemiol Prev , vol.26 , pp. 284-286
    • Mirabelli, D.1    Cadum, E.2
  • 30
    • 77955495793 scopus 로고    scopus 로고
    • DNA double-strand breaks by asbestos, silica, and titanium dioxide. Possible biomarker of carcinogenic potential?
    • Msiska Z., Pacurari M., Mishra A., Leonard S.S., Castranova V., Vallyathan V. DNA double-strand breaks by asbestos, silica, and titanium dioxide. Possible biomarker of carcinogenic potential?. Am J Respir Cell Mol Biol 2010, 43:210-219.
    • (2010) Am J Respir Cell Mol Biol , vol.43 , pp. 210-219
    • Msiska, Z.1    Pacurari, M.2    Mishra, A.3    Leonard, S.S.4    Castranova, V.5    Vallyathan, V.6
  • 31
    • 0024360191 scopus 로고
    • Evidence supporting a role for active oxygen species in asbestos induced toxicity and lung disease
    • Mossman B.T., Marsh J.P. Evidence supporting a role for active oxygen species in asbestos induced toxicity and lung disease. Environ Health Perspect 1989, 81:91-94.
    • (1989) Environ Health Perspect , vol.81 , pp. 91-94
    • Mossman, B.T.1    Marsh, J.P.2
  • 33
    • 79959691918 scopus 로고    scopus 로고
    • Mineral fibre toxicity: expression of retinoblastoma (Rb) and phosphor retinoblastoma (pRb) protein in alveolar epithelial and mesothelial cell lines exposed to fluoro-edenite fibres
    • Musumeci G., Cardile V., Fenga C., Caggia S., Loreto C. Mineral fibre toxicity: expression of retinoblastoma (Rb) and phosphor retinoblastoma (pRb) protein in alveolar epithelial and mesothelial cell lines exposed to fluoro-edenite fibres. Cell Biol Toxicol 2011, 27:217-225.
    • (2011) Cell Biol Toxicol , vol.27 , pp. 217-225
    • Musumeci, G.1    Cardile, V.2    Fenga, C.3    Caggia, S.4    Loreto, C.5
  • 34
    • 0347286962 scopus 로고    scopus 로고
    • Involvement of Cdc42 and Rac small G proteins in invadopodia formation of RPMI7951 cells
    • Nakahara H., Otani T., Sasaki T., Miura Y., Takai Y., Kogo M. Involvement of Cdc42 and Rac small G proteins in invadopodia formation of RPMI7951 cells. Genes Cells 2003, 8:1019-1027.
    • (2003) Genes Cells , vol.8 , pp. 1019-1027
    • Nakahara, H.1    Otani, T.2    Sasaki, T.3    Miura, Y.4    Takai, Y.5    Kogo, M.6
  • 35
    • 77954938872 scopus 로고    scopus 로고
    • Phosphatase of regenerating liver-1 promotes cell migration and invasion and regulates filamentous actin dynamics
    • Nakashima M., Lazo J.S. Phosphatase of regenerating liver-1 promotes cell migration and invasion and regulates filamentous actin dynamics. J Pharmacol Exp Ther 2010, 334:627-633.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 627-633
    • Nakashima, M.1    Lazo, J.S.2
  • 36
    • 0033014565 scopus 로고    scopus 로고
    • Biological effects of naturally occurring and man-made fibres: in vitro cytotoxicity and mutagenesis in mammalian cells
    • Okayasu R., Wu L., Hei T.K. Biological effects of naturally occurring and man-made fibres: in vitro cytotoxicity and mutagenesis in mammalian cells. Br J Cancer 1999, 79:1319-1324.
    • (1999) Br J Cancer , vol.79 , pp. 1319-1324
    • Okayasu, R.1    Wu, L.2    Hei, T.K.3
  • 39
    • 75549087019 scopus 로고    scopus 로고
    • Effects of asbestiform antigorite on human alveolar epithelial A549 cells: a morphological and immunohistochemical study
    • Pugnaloni A., Giantomassi F., Lucarini G., Capella S., Belmonte M.M., Orciani M., et al. Effects of asbestiform antigorite on human alveolar epithelial A549 cells: a morphological and immunohistochemical study. Acta Histochem 2010, 112:133-146.
    • (2010) Acta Histochem , vol.112 , pp. 133-146
    • Pugnaloni, A.1    Giantomassi, F.2    Lucarini, G.3    Capella, S.4    Belmonte, M.M.5    Orciani, M.6
  • 40
    • 0034997092 scopus 로고    scopus 로고
    • Rho Proteins: linking signaling with membrane trafficking
    • Ridley A. Rho Proteins: linking signaling with membrane trafficking. Traffic 2001, 2:303-310.
    • (2001) Traffic , vol.2 , pp. 303-310
    • Ridley, A.1
  • 41
    • 4444366235 scopus 로고    scopus 로고
    • Assessment of the use of Raman spectroscopy for the determination of amphibole asbestos
    • Rinaudo C., Belluso E., Gastaldi D. Assessment of the use of Raman spectroscopy for the determination of amphibole asbestos. Mineral Mag 2004, 68:455-465.
    • (2004) Mineral Mag , vol.68 , pp. 455-465
    • Rinaudo, C.1    Belluso, E.2    Gastaldi, D.3
  • 42
    • 77949350943 scopus 로고    scopus 로고
    • Malignant mesothelioma
    • Rudd R.M. Malignant mesothelioma. Br Med Bull 2010, 93:105-123.
    • (2010) Br Med Bull , vol.93 , pp. 105-123
    • Rudd, R.M.1
  • 43
    • 77957882549 scopus 로고    scopus 로고
    • Cyto-genotoxicity of amphibole asbestos fibers in cultured human lung epithelial cell line: role of surface iron
    • Srivastava R.K., Lohani M., Pant A.B., Rahman Q. Cyto-genotoxicity of amphibole asbestos fibers in cultured human lung epithelial cell line: role of surface iron. Toxicol Ind Health 2010, 26:575-582.
    • (2010) Toxicol Ind Health , vol.26 , pp. 575-582
    • Srivastava, R.K.1    Lohani, M.2    Pant, A.B.3    Rahman, Q.4
  • 44
    • 0019846414 scopus 로고
    • Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals
    • Stanton M.F., Layard M., Tegeris A., Miller E., May M., Morgan E., et al. Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J Natl Cancer Inst 1981, 67:965-975.
    • (1981) J Natl Cancer Inst , vol.67 , pp. 965-975
    • Stanton, M.F.1    Layard, M.2    Tegeris, A.3    Miller, E.4    May, M.5    Morgan, E.6
  • 45
    • 17844410911 scopus 로고    scopus 로고
    • Short, thin asbestos fibers contribute to the development of human malignant mesothelioma: pathological evidence
    • Suzuki Y., Yuen S.R., Ashley R. Short, thin asbestos fibers contribute to the development of human malignant mesothelioma: pathological evidence. Int J Hyg Environ Health 2005, 208:201-210.
    • (2005) Int J Hyg Environ Health , vol.208 , pp. 201-210
    • Suzuki, Y.1    Yuen, S.R.2    Ashley, R.3
  • 46
    • 33748269365 scopus 로고    scopus 로고
    • Quantification of immunohistochemistry - issues concerning methods, utility and semiquantitative assessment II
    • Taylor C.R., Levenson R.M. Quantification of immunohistochemistry - issues concerning methods, utility and semiquantitative assessment II. Histopathology 2006, 49:411-424.
    • (2006) Histopathology , vol.49 , pp. 411-424
    • Taylor, C.R.1    Levenson, R.M.2
  • 47
    • 0002472257 scopus 로고
    • Characteristics of the International Union Against Cancer standard reference samples of asbestos
    • Oxford University Press, Oxford, H.A. Shapiro (Ed.)
    • Timbrell V. Characteristics of the International Union Against Cancer standard reference samples of asbestos. Pneumoconiosis, Proceedings of the International Conference 1970, 28-36. Oxford University Press, Oxford. H.A. Shapiro (Ed.).
    • (1970) Pneumoconiosis, Proceedings of the International Conference , pp. 28-36
    • Timbrell, V.1
  • 48
    • 65549136242 scopus 로고    scopus 로고
    • Mechanisms of asbestos-induced carcinogenesis
    • Toyokuni S. Mechanisms of asbestos-induced carcinogenesis. Nagoya J Med Sci 2009, 71:1-10.
    • (2009) Nagoya J Med Sci , vol.71 , pp. 1-10
    • Toyokuni, S.1
  • 49
    • 68149147430 scopus 로고    scopus 로고
    • Role of associated mineral fibres in chrysotile asbestos health effects: the case of balangeroite
    • Turci F., Tomatis M., Compagnoni R., Fubini B. Role of associated mineral fibres in chrysotile asbestos health effects: the case of balangeroite. Ann Occup Hyg 2009, 53:491-497.
    • (2009) Ann Occup Hyg , vol.53 , pp. 491-497
    • Turci, F.1    Tomatis, M.2    Compagnoni, R.3    Fubini, B.4
  • 50
    • 0036144596 scopus 로고    scopus 로고
    • Distinct spectrum of mutations induced by crocidolite asbestos: clue for 8-hydroxydeoxyguanosine-dependent mutagenesis in vivo
    • Unfried K., Schürkes C., Abel J. Distinct spectrum of mutations induced by crocidolite asbestos: clue for 8-hydroxydeoxyguanosine-dependent mutagenesis in vivo. Cancer Res 2002, 62:99-104.
    • (2002) Cancer Res , vol.62 , pp. 99-104
    • Unfried, K.1    Schürkes, C.2    Abel, J.3
  • 51
    • 0037828891 scopus 로고    scopus 로고
    • Asbestos-induced pulmonary toxicity: role of DNA damage and apoptosis
    • Upadhyay D., Kamp D.W. Asbestos-induced pulmonary toxicity: role of DNA damage and apoptosis. Exp Biol Med (Maywood) 2003, 228:650-659.
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 650-659
    • Upadhyay, D.1    Kamp, D.W.2
  • 53
    • 0037158893 scopus 로고    scopus 로고
    • Differentially expressed genes associated with mouse lung tumor progression
    • Yao R., Wang Y., Lubet R.A., You M. Differentially expressed genes associated with mouse lung tumor progression. Oncogene 2002, 21:5814-5821.
    • (2002) Oncogene , vol.21 , pp. 5814-5821
    • Yao, R.1    Wang, Y.2    Lubet, R.A.3    You, M.4
  • 54
    • 38849204971 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity
    • Zhang S., Schafer-Hales K., Khuri F.R., Zhou W., Vertino P.M., Marcus A.I. The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. Cancer Res 2008, 68:740-748.
    • (2008) Cancer Res , vol.68 , pp. 740-748
    • Zhang, S.1    Schafer-Hales, K.2    Khuri, F.R.3    Zhou, W.4    Vertino, P.M.5    Marcus, A.I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.