Concurrent delivery of tocotrienols and simvastatin by lipid nanoemulsions potentiates their antitumor activity against human mammary adenocarcenoma cells

European Journal of Pharmaceutical Sciences

Volumn 48, Issue 3, 2013, Pages 385-392

  Alayoubi, Alaadin Y ^a   Anderson, John F ^a   Satyanarayanajois, Seetharama D ^a   Sylvester, Paul W ^a   Nazzal, Sami ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Antiproliferation; Nanoemulsion; Parenteral lipid emulsion; Simvastatin; Tocotrienol

Indexed keywords

ALPHA TOCOTRIENOL; SIMVASTATIN; ANTINEOPLASTIC AGENT; DRUG COMBINATION; EMULSION; LIPID EMULSION; NANOMATERIAL; TRIACYLGLYCEROL;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CELL STRAIN MCF 7; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NANOEMULSION; OXIDATION; PRIORITY JOURNAL; SCANNING TRANSMISSION ELECTRON MICROSCOPY; ADENOCARCINOMA; BREAST NEOPLASMS; CELL PROLIFERATION; CHEMISTRY; DRUG COMBINATION; DRUG EFFECTS; DRUG FORMULATION; DRUG POTENTIATION; DRUG STABILITY; EMULSION; FEMALE; SOLUBILITY; SURFACE PROPERTY; TUMOR CELL LINE; ULTRASTRUCTURE; VISCOSITY;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG COMBINATIONS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; DRUG SYNERGISM; EMULSIONS; FAT EMULSIONS, INTRAVENOUS; FEMALE; HUMANS; NANOSTRUCTURES; SIMVASTATIN; SOLUBILITY; SURFACE PROPERTIES; TOCOTRIENOLS; TRIGLYCERIDES; VISCOSITY;

EID: 84872412136     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.12.011     Document Type: Article

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