A category approach to predicting the repeated-dose hepatotoxicity of allyl esters

Regulatory Toxicology and Pharmacology

Volumn 65, Issue 2, 2013, Pages 189-195

  Yamada, Takashi ^a   Tanaka, Yushiro ^a   Hasegawa, Ryuichi ^a   Sakuratani, Yuki ^a   Yamada, Jun ^a   Kamata, Eiichi ^b   Ono, Atsushi ^b   Hirose, Akihiko ^b   Yamazoe, Yasushi ^c   Mekenyan, Ovanes ^d   Hayashi, Makoto ^e  

^a NATIONAL INSTITUTE OF TECHNOLOGY AND EVALUATION   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d ASSEN ZLATAROV UNIVERSITY   (Bulgaria)

^e Biosafety Research Center   (Japan)

Author keywords

Adverse outcome pathway; Allyl ester; Category approach; Hepatotoxicity; Repeated dose toxicity

Indexed keywords

3 HYDROXYPROPYLMERCAPTURIC ACID; ACROLEIN; ALLYL 2 ETHYLHEXANOIC ACID; ALLYL ACETATE; ALLYL ALCOHOL; ALLYL BENZOIC ACID; ALLYL BUTYRIC ACID; ALLYL CINNAMIC ACID; ALLYL COMPOUND; ALLYL ESTER; ALLYL HEPTANOIC ACID; ALLYL HEXANOIC ACID; ALLYL ISOPROPIONIC ACID; ALLYL ISOVALERIC ACID; ALLYL PROPIONIC ACID; ALLYL STEARIC ACID; ALLYL VALERIC ACID; AROMATIC CARBOXYLIC ACID; DECANOIC ACID; DIALLYL PHTHALIC ACID; NONANOIC ACID; OCTANOIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; HYDROLYSIS; LIVER TOXICITY; NONHUMAN; OXIDATION; PREDICTION; PRIORITY JOURNAL; RAT; REPEATED DOSE TOXICITY; STRUCTURE ANALYSIS; TOXICITY; TOXICOKINETICS;

ALLYL COMPOUNDS; ANIMALS; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ESTERS; FORECASTING; HEPATOCYTES; HUMANS; LIVER; NO-OBSERVED-ADVERSE-EFFECT LEVEL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872409885     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2012.12.001     Document Type: Article

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