Transforming growth factor β repressor, SnoN, is overexpressed in human gastrointestinal stromal tumors

Journal of B.U.ON.

Volumn 17, Issue 4, 2012, Pages 684-690

  Bravou, V ^a,b   Papanastasopoulos, P ^a,b   Verras, D ^a   Kotsikogianni, I ^a   Damaskou, V ^a   Repanti, M ^a  

^a General hospitalof'Patras Agios Andreas ^*  (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

GIST; p21WAF1 CIP; p27KIP1; Smad2; SnoN; T RII

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PROTEIN SNON; REPRESSOR PROTEIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; CANCER GRADING; CANCER PROGNOSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; GASTROINTESTINAL STROMAL TUMOR; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MITOSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TUMOR LOCALIZATION; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; CARCINOEMBRYONIC ANTIGEN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; GASTROINTESTINAL NEOPLASMS; GASTROINTESTINAL STROMAL TUMORS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD2 PROTEIN;

EID: 84872409122     PISSN: 11070625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Fletcher CD, Berman JJ, Corless C et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 2002;33:459-465. (Pubitemid 34747864)
2. Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 2006; 130: 1466-1478. (Pubitemid 44520713)
3. Maeda H, Yamagata A, Nishikawa S et al. Requirement of ckit for development of intestinal pacemaker system. Development 1992; 116:369-375.
4. Huizinga JD, Thuneberg L, Kliippel M, Malysz J, Mikkelsen HB, Bernstein A. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 1995; 373: 347-349.
5. Elliott RL, Blobe GC. Role of transforming growth factor Beta in human cancer. J Clin Oncol 2005; 23: 2078-2093. (Pubitemid 46211385)
6. Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K. Negative feedback regulation of TFG-beta signalling by the SnoN oncoprotein. Science 1999; 286: 771-774.
7. Luo K. Ski and SnoN: negative regulators of TGF-beta signaling. Curr Opin Genet Dev 2004; 14: 65-70. (Pubitemid 38167479)
8. Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001; 29: 117-129. (Pubitemid 32952643)
9. Bachman KE, Park BH. Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter. Curr Opin Oncol 2005; 17:49-54. (Pubitemid 40179912)
10. Veruschi A, Sferra R, Latella G et al. Smad3-null mice lack interstitial cells of Cajal in the colonic wall. Eur J Clin Invest 2006; 36: 41-48.
11. Reynisdóttir I, Polyak K, Iavarone A, Massagué J. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 1995;9:1831-1845.
12. Yoo J, Park SY, Kang SJ, Shim SI, Kim BK. Altered expression of Gl regulatory proteins in human soft tissue sarcomas. Arch Pathol Lab Med 2002; 126:567-573. (Pubitemid 34477952)
13. Sabah M, Cummins R, Leader M, Kay E. Altered expression of cell cycle regulatory proteins in gastrointestinal stromal tumors: markers with potential prognostic implications. Hum Pathol 2006; 37: 648-655. (Pubitemid 43956544)
14. Ye L, Zhang H, Zhang L et al. Effects of RNAi-mediated Smad4 silencing on growth and apoptosis of human rhabdomyosarcoma cells. Int J Oncol 2006; 29:1149-1157.
15. Navid F, Letterio JJ, Yeung CL, Pegtel M, Helman LJ. Autocrine Transforming Growth Factor-beta Growth Pathway in Murine Osteosarcoma Cell Lines Associated with Inability to Affect Phosphorylation of Retinoblastoma Protein. Sarcoma 2000;4:93-102.
16. Muro-Cacho CA, Anderson M, Cordero J, Muñoz-Antonia T. Expression of transforming growth factor beta type II receptors in head and neck squamous cell carcinoma. Clin Cancer Res 1999;5:1243-1248. (Pubitemid 29282926)
17. Bravou V, Antonacopoulou A, Papadaki H et al. TGF-beta repressors SnoN and Ski are implicated in human colorectal carcinogenesis. Cell Oncol 2009; 31:41-51.
18. Picon A, Gold LI, Wang J, Cohen A, Friedman E. A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor beta1. Cancer Epidemiol BiomarkersPrev 1998; 7: 497-504. (Pubitemid 28354113)
19. Boyer PL, Colmenares C, Stavnezer E, Hughes SH. Sequence and biological activity of chicken snoN cDNA clones. Oncogene 1993; 8: 457-466. (Pubitemid 23073762)
20. Buess M, Terracciano L, Reuter J et al. Amplification of SKI is a prognostic marker in early colorectal cancer. Neoplasia 2004; 6: 207-212. (Pubitemid 38657076)
21. Zhang F, Lundin M, Ristimaki A et al. Ski-related novel protein N (SnoN), a negative controller of transforming growth factor-beta signaling, is a prognostic marker in estrogen receptor-positive breast carcinomas. Cancer Res 2003; 63: 5005-5010. (Pubitemid 37022638)
22. Reed JA, Bales E, Xu W, Okan NA, Bandyopadhyay D, Mediano EE. Cytoplasmic localization of the oncogenic protein Ski in human cutaneous melanomas in vivo: functional implications for transforming growth factor beta signaling. Cancer Res 2001; 61: 8074-8078. (Pubitemid 33091592)
23. Zhu Q, Pearson-White S, Luo K. Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogeniv transformation of fibroblast cells. Mol Cell Biol 2005; 25: 10731-10744. (Pubitemid 41747119)
24. Krakowski AR, Laboureau J, Mauviel A, Bissell MJ, Luo K. Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins. Proc Natl Acad Sci USA2005; 102: 12437-12442. (Pubitemid 41266377)
25. Nakamura N, Yamamoto H, Yao T et al. Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade. Hum Pathol 2005; 36:828-837. (Pubitemid 41112040)
26. Viglietto G, Motti ML, Bruni P et al. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kipl) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med 2002; 8:1136-1144. (Pubitemid 35175969)
27. Rosen DG, Yang G, Cai KQ et al. Subcellular localization of p27kip 1 expression predicts poor prognosis in human ovarian cancer. Clin Cancer Res 2005; 11: 632-637. (Pubitemid 40116889)
28. Denicourt C, Saenz CC, Datnow B, Cui XS, Dowdy SF. Relocalized p27Kip1 rumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma. Cancer Res 2007; 67: 9238-9243. (Pubitemid 47535911)