Ginsenoside Rg1 attenuates structural disruption of the blood-brain barrier to protect the central nervous system in ischemia/reperfusion

Chinese Journal of Natural Medicines

Volumn 11, Issue 1, 2013, Pages 30-37

  Wang, Rui ^a   Wang, Guang Ji ^b   Wu, Xiao Lan ^b   Zhou, Fang ^b   Li, Yan Nan ^b  

^a Jiangsu Simcere Diagnostics Co   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Blood brain barrier; Extracellular matrix; Ginsenoside Rg1; Matrix metalloproteinases; Tissue inhibitor of matrix metalloproteinases

Indexed keywords

EVANS BLUE; GINSENOSIDE RG 1; MALONALDEHYDE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; SUPEROXIDE DISMUTASE; TISSUE INHIBITOR OF MATRIX METALLOPROTEINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; BLOOD BRAIN BARRIER; BRAIN CELL; BRAIN ISCHEMIA; BRAIN MICROVASCULAR ENDOTHELIAL CELL; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFICACY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REPERFUSION INJURY; SHAM PROCEDURE; SUTURING METHOD;

EID: 84872406838     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(13)60004-7     Document Type: Article

References (24)

1. Liu M, Zhang JT Protective effects of ginsenoside Rb1 and Rg1 on cultured hippocampal neurons [J]. Acta Pharm Sin 1995, 30(9):674-678.
2. Li X, Chen JX, Sun JJ Protective effects of Panax notoginseng saponins on experimental myocardial injury induced by ischemia and reperfusion in rat [J]. Acta Pharmacol Sin 1990, 11(1):26-29.
3. Zhu LQ, Fan JP, Huang QF, et al. Study on the anti-apoptosis induced by hypoxia/hypoglycemia and reoxygenation of Panax notoginseng saponins in cultured rat hippocampal neurons [J]. China J Chin Meter Med 2003, 28(1):52-55.
4. Wang R, Li YN, Wang GJ, et al. Neuroprotective effects and brain transport study of ginsenoside Rg1 [J]. Chin J Nat Med 2009, 4(6):315-320.
5. Koizumi J, Yoshida Y, Nakazawa T, et al. Experimental studies of ischemic brain edema: 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemia area [J]. Jpn J Stroke 1986, 8:1-8.
6. Yamakami J, Sakurai E, Sakurada T, et al. Stereoselective blood-brain barrier transport of histidine in rats [J]. Brain Res 1998, 812(1-2):105-112.
7. Belayev L, Busto R, Zhao W, et al. Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats [J]. Brain Res 1996, 739(1-2):88-96.
8. Liu M, Zhang JT Ameliorating age-related alterations of ginsenoside Rg1 in open-field behavioral activity and motor responses in old rats [J]. Chin Pharmacol J 1996, 31(8):464-467.
9. Lai H, Lu YL, Bao F The changes of the neurons in hippocampus of aged rats and the effects of ginsenoside on the neurons [J]. J Chin Pharm Coll 1996, 25(3):225-228.
10. Radad K, Gille G, Moldzio R, et al. Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate [J]. Brain Res 2004, 1021(1):41-53.
11. Petty MA, Wettstein JG Elements of cerebral microvascular ischemia[J]. Brain Res Rev 2001, 36(1):23-34.
12. Nag S The blood-brain barrier and cerebral angiogenesis: lessons from the cold-injury model [J]. Trends Mol Med 2002, 8(1):38-44.
13. Uyama O, Okamura N, Yanase M, et al. Quantitative evaluation of vascular permeability in the gerbil brain after transient ischemia using Evans blue fluorescence [J]. J Cereb Blood Flow Metab 1988, 8(2):282-284.
14. Grant GA, Abbott NJ, Janigro D Understanding the physiology of the blood-brain barrier: in vitro models [J]. News Physiol Sci 1998, 13:287-293.
15. Ballabh P, Braun A, Nedergaard M The blood-brain barrier: an overview. Structure, regulation, and clinical implications [J]. Neurobiol Dis 2004, 16(1):1-13.
16. Hawkins BT, Davis TP The blood-brain barrier/neurovascular unit in health and disease [J]. Pharmacol Rev 2005, 57(2):173-185.
17. Ilhan N, Halifeoglu I, Ozercan HI, et al. Tissue malondialdehyde and adenosine triphosphatase level after experimental liver ischemia reperfusion damage [J]. Cell Biochem Funct 2001, 19(3):207-212.
18. Hua JS, Li LP, Zhu XM Effects of moxibustion pretreating on SOD and MDA in the rat of global brain ischemia [J]. J Tradit Chin Med 2008, 28(4):289-292.
19. Lee SR, Lo EH Induction of caspase-mediated cell death by matrix metalloproteinases in cerebral endothelial cells after hypoxia-reoxygenation [J]. J Cereb Blood Flow Metab 2004, 24(7):720-727.
20. Clark AW, Krekoski CA, Bou SS, et al. Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia [J]. Neurosci Lett 1997, 238(1-2):53-56.
21. Montaner J, Alvarez-Sabín J, Molina CA, et al. Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke [J]. Stroke 2001, 32(12):2762-2767.
22. Rosenberg GA, Estrada FY, Dencoff JE Matrix metalloproteinase and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain [J]. Stroke 1998, 29(10):2189-2195.
23. Gomez DE, Alonso DF, Yoshiji H, et al. Tissue inhibitors of metalloproteinases: structure, regulation and biological functions [J]. Eur J Cell Biol 1997, 74(2):111-122.
24. Fassina G, Ferrari N, Brigati C, et al. Tissue inhibitors of metalloproteinases: regulation and biological activities [J]. Clin Exp Metastasis 2000, 18(2):111-120.