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Volumn 37, Issue 2, 2013, Pages 221-227

Novel players in multiple myeloma pathogenesis: Role of protein kinases CK2 and GSK3

Author keywords

Bone disease; ER stress UPR response; Multiple myeloma; NF B; Protein kinase CK2; Protein kinase GSK3; STAT3; Targeted therapy

Indexed keywords

APIGENIN; CASEIN KINASE II; CELL CYCLE PROTEIN 37; DICKKOPF 1 PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN 90; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; STAT3 PROTEIN; SURVIVIN; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR MAFB; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84872399759     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2012.10.016     Document Type: Review
Times cited : (28)

References (44)
  • 2
    • 56449128746 scopus 로고    scopus 로고
    • New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings
    • Ocio E.M., Mateos M.V., Maiso P., Pandiella A., San-Miguel J.F. New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings. Lancet Oncol 2008 Dec, 9(12):1157-1165.
    • (2008) Lancet Oncol , vol.9 , Issue.12 , pp. 1157-1165
    • Ocio, E.M.1    Mateos, M.V.2    Maiso, P.3    Pandiella, A.4    San-Miguel, J.F.5
  • 3
    • 64749088834 scopus 로고    scopus 로고
    • Emerging treatments for multiple myeloma: beyond immunomodulatory drugs and bortezomib
    • Mitsiades C.S., Hideshima T., Chauhan D., McMillin D.W., Klippel S., Laubach J.P., et al. Emerging treatments for multiple myeloma: beyond immunomodulatory drugs and bortezomib. Semin Hematol 2009, 46(April (2)):166-175.
    • (2009) Semin Hematol , vol.46 , Issue.APRIL 2 , pp. 166-175
    • Mitsiades, C.S.1    Hideshima, T.2    Chauhan, D.3    McMillin, D.W.4    Klippel, S.5    Laubach, J.P.6
  • 4
    • 84860219443 scopus 로고    scopus 로고
    • The genetic architecture of multiple myeloma
    • Morgan G.J., Walker B.A., Davies F.E. The genetic architecture of multiple myeloma. Nat Rev Cancer 2012, 12(May (5)):335-348.
    • (2012) Nat Rev Cancer , vol.12 , Issue.MAY 5 , pp. 335-348
    • Morgan, G.J.1    Walker, B.A.2    Davies, F.E.3
  • 6
  • 7
    • 85027944452 scopus 로고    scopus 로고
    • Novel therapies in MM: from the aspect of preclinical studies
    • Hideshima T., Anderson K.C. Novel therapies in MM: from the aspect of preclinical studies. Int J Hematol 2011, 94(October (4)):344-354.
    • (2011) Int J Hematol , vol.94 , Issue.OCTOBER 4 , pp. 344-354
    • Hideshima, T.1    Anderson, K.C.2
  • 8
    • 75349084777 scopus 로고    scopus 로고
    • Addiction to protein kinase CK2: a common denominator of diverse cancer cells?
    • Ruzzene M., Pinna L.A. Addiction to protein kinase CK2: a common denominator of diverse cancer cells?. Biochim Biophys Acta 2010, 1804(March (3)):499-504.
    • (2010) Biochim Biophys Acta , vol.1804 , Issue.MARCH 3 , pp. 499-504
    • Ruzzene, M.1    Pinna, L.A.2
  • 9
    • 8744271562 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?
    • November
    • Patel S., Doble B., Woodgett J.R. Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?. Biochem Soc Trans 2004, 32(November (Pt 5)):803-808.
    • (2004) Biochem Soc Trans , vol.32 , Issue.PART 5 , pp. 803-808
    • Patel, S.1    Doble, B.2    Woodgett, J.R.3
  • 10
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NF-kappaB
    • Chen L.F., Greene W.C. Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 2004, 5(May (5)):392-401.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , Issue.MAY 5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2
  • 11
    • 0037043777 scopus 로고    scopus 로고
    • Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis
    • Channavajhala P., Seldin D.C. Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis. Oncogene 2002, 21(August (34)):5280-5288.
    • (2002) Oncogene , vol.21 , Issue.AUGUST 34 , pp. 5280-5288
    • Channavajhala, P.1    Seldin, D.C.2
  • 12
    • 78449239639 scopus 로고    scopus 로고
    • GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms
    • Kitagawa K., Kotake Y., Hiramatsu Y., Liu N., Suzuki S., Nakamura S., et al. GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms. Cell Div 2010, 5:27.
    • (2010) Cell Div , vol.5 , pp. 27
    • Kitagawa, K.1    Kotake, Y.2    Hiramatsu, Y.3    Liu, N.4    Suzuki, S.5    Nakamura, S.6
  • 13
    • 79251515755 scopus 로고    scopus 로고
    • Serine-threonine protein kinases CK1, CK2 and GSK3 in normal and malignant haematopoiesis
    • Piazza F., Manni S., Colpo A., Tubi L.Q., Gurrieri C., Semenzato G. Serine-threonine protein kinases CK1, CK2 and GSK3 in normal and malignant haematopoiesis. Curr Signal Transd Ther 2011, 6(January (1)):88-98.
    • (2011) Curr Signal Transd Ther , vol.6 , Issue.JANUARY 1 , pp. 88-98
    • Piazza, F.1    Manni, S.2    Colpo, A.3    Tubi, L.Q.4    Gurrieri, C.5    Semenzato, G.6
  • 14
    • 70349320107 scopus 로고    scopus 로고
    • Protein kinase CK2 in health and disease: CK2: a key player in cancer biology
    • Trembley J.H., Wang G., Unger G., Slaton J., Ahmed K. Protein kinase CK2 in health and disease: CK2: a key player in cancer biology. Cell Mol Life Sci 2009, 66(June (11-12)):1858-1867.
    • (2009) Cell Mol Life Sci , vol.66 , Issue.JUNE 11 12 , pp. 1858-1867
    • Trembley, J.H.1    Wang, G.2    Unger, G.3    Slaton, J.4    Ahmed, K.5
  • 16
    • 75349084777 scopus 로고    scopus 로고
    • Addiction to protein kinase CK2: a common denominator of diverse cancer cells?
    • Ruzzene M., Pinna L.A. Addiction to protein kinase CK2: a common denominator of diverse cancer cells?. Biochim Biophys Acta 2010 Mar, 1804(3):499-504.
    • (2010) Biochim Biophys Acta , vol.1804 , Issue.3 , pp. 499-504
    • Ruzzene, M.1    Pinna, L.A.2
  • 17
    • 84862005662 scopus 로고    scopus 로고
    • Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways
    • Piazza F., Manni S., Ruzzene M., Pinna L.A., Gurrieri C., Semenzato G. Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways. Leukemia 2012, 26(6):1174-1179.
    • (2012) Leukemia , vol.26 , Issue.6 , pp. 1174-1179
    • Piazza, F.1    Manni, S.2    Ruzzene, M.3    Pinna, L.A.4    Gurrieri, C.5    Semenzato, G.6
  • 18
    • 33748163052 scopus 로고    scopus 로고
    • Multiple myeloma cell survival relies on high activity of protein kinase CK2
    • Piazza F.A., Ruzzene M., Gurrieri C., Montini B., Bonanni L., Chioetto G., et al. Multiple myeloma cell survival relies on high activity of protein kinase CK2. Blood 2006 Sep 1, 108(5):1698-1707.
    • (2006) Blood , vol.108 , Issue.5 , pp. 1698-1707
    • Piazza, F.A.1    Ruzzene, M.2    Gurrieri, C.3    Montini, B.4    Bonanni, L.5    Chioetto, G.6
  • 19
    • 34948890040 scopus 로고    scopus 로고
    • Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
    • Davenport E.L., Moore H.E., Dunlop A.S., Sharp S.Y., Workman P., Morgan G.J., et al. Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. Blood 2007, 110(October (7)):2641-2649.
    • (2007) Blood , vol.110 , Issue.OCTOBER 7 , pp. 2641-2649
    • Davenport, E.L.1    Moore, H.E.2    Dunlop, A.S.3    Sharp, S.Y.4    Workman, P.5    Morgan, G.J.6
  • 20
    • 77953153048 scopus 로고    scopus 로고
    • Regulation of basal cellular physiology by the homeostatic unfolded protein response
    • Rutkowski D.T., Hegde R.S. Regulation of basal cellular physiology by the homeostatic unfolded protein response. J Cell Biol 2010, 189(May (5)):783-794.
    • (2010) J Cell Biol , vol.189 , Issue.MAY 5 , pp. 783-794
    • Rutkowski, D.T.1    Hegde, R.S.2
  • 21
    • 79251589342 scopus 로고    scopus 로고
    • Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
    • Papandreou I., Denko N.C., Olson M., Van Melckebeke H., Lust S., Tam A., et al. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 2010, 117(January (4)):1311-1314.
    • (2010) Blood , vol.117 , Issue.JANUARY 4 , pp. 1311-1314
    • Papandreou, I.1    Denko, N.C.2    Olson, M.3    Van Melckebeke, H.4    Lust, S.5    Tam, A.6
  • 22
    • 1942486312 scopus 로고    scopus 로고
    • CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37
    • Miyata Y., Nishida E. CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. Mol Cell Biol 2004, 24(May (9)):4065-4074.
    • (2004) Mol Cell Biol , vol.24 , Issue.MAY 9 , pp. 4065-4074
    • Miyata, Y.1    Nishida, E.2
  • 23
    • 84859409979 scopus 로고    scopus 로고
    • Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response
    • Manni S., Brancalion A., Tubi L.Q., Colpo A., Pavan L., Cabrelle A., et al. Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response. Clin Cancer Res: Off J Am Assoc Cancer Res 2012, 18(April (7)):1888-1900.
    • (2012) Clin Cancer Res: Off J Am Assoc Cancer Res , vol.18 , Issue.APRIL 7 , pp. 1888-1900
    • Manni, S.1    Brancalion, A.2    Tubi, L.Q.3    Colpo, A.4    Pavan, L.5    Cabrelle, A.6
  • 24
    • 80052023055 scopus 로고    scopus 로고
    • Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2 Cdc37 and Hsp90
    • Zhao M., Ma J., Zhu H.Y., Zhang X.H., Du Z.Y., Xu Y.J., et al. Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2 Cdc37 and Hsp90. Mol Cancer 2011, 10:104.
    • (2011) Mol Cancer , vol.10 , pp. 104
    • Zhao, M.1    Ma, J.2    Zhu, H.Y.3    Zhang, X.H.4    Du, Z.Y.5    Xu, Y.J.6
  • 25
    • 77957803826 scopus 로고    scopus 로고
    • CK2 inhibition induces apoptosis via the ER stress response
    • Hessenauer A., Schneider C.C., Gotz C., Montenarh M. CK2 inhibition induces apoptosis via the ER stress response. Cell Signal 2011, 23(January (1)):145-151.
    • (2011) Cell Signal , vol.23 , Issue.JANUARY 1 , pp. 145-151
    • Hessenauer, A.1    Schneider, C.C.2    Gotz, C.3    Montenarh, M.4
  • 26
    • 84863084759 scopus 로고    scopus 로고
    • Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells
    • Hosoi T., Korematsu K., Horie N., Suezawa T., Okuma Y., Nomura Y., et al. Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells. PLoS One 2012, 7(6):e40144.
    • (2012) PLoS One , vol.7 , Issue.6
    • Hosoi, T.1    Korematsu, K.2    Horie, N.3    Suezawa, T.4    Okuma, Y.5    Nomura, Y.6
  • 27
    • 0035477020 scopus 로고    scopus 로고
    • GSK3 takes centre stage more than 20 years after its discovery
    • October
    • Frame S., Cohen P. GSK3 takes centre stage more than 20 years after its discovery. Biochem J 2001, 359(October (Pt 1)):1-16.
    • (2001) Biochem J , vol.359 , Issue.PART 1 , pp. 1-16
    • Frame, S.1    Cohen, P.2
  • 29
    • 0033851276 scopus 로고    scopus 로고
    • GSK3, a master switch regulating cell-fate specification and tumorigenesis
    • Kim L., Kimmel A.R. GSK3, a master switch regulating cell-fate specification and tumorigenesis. Curr Opin Genet Dev 2000, 10(October (5)):508-514.
    • (2000) Curr Opin Genet Dev , vol.10 , Issue.OCTOBER 5 , pp. 508-514
    • Kim, L.1    Kimmel, A.R.2
  • 30
    • 33947597084 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics
    • Jope R.S., Yuskaitis C.J., Beurel E. Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res 2007, 32(April-May (4-5)):577-595.
    • (2007) Neurochem Res , vol.32 , Issue.APRIL MAY 4 5 , pp. 577-595
    • Jope, R.S.1    Yuskaitis, C.J.2    Beurel, E.3
  • 31
    • 0034612636 scopus 로고    scopus 로고
    • Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
    • Hoeflich K.P., Luo J., Rubie E.A., Tsao M.S., Jin O., Woodgett J.R. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 2000, 406(July (6791)):86-90.
    • (2000) Nature , vol.406 , Issue.JULY 6791 , pp. 86-90
    • Hoeflich, K.P.1    Luo, J.2    Rubie, E.A.3    Tsao, M.S.4    Jin, O.5    Woodgett, J.R.6
  • 32
    • 0036031664 scopus 로고    scopus 로고
    • Regulation of myeloma cell growth through Akt/Gsk3/forkhead signaling pathway
    • G-Amlak M., Uddin S., Mahmud D., Damacela I., Lavelle D., Ahmed M., et al. Regulation of myeloma cell growth through Akt/Gsk3/forkhead signaling pathway. Biochem Biophys Res Commun 2002, 297(October (4)):760-764.
    • (2002) Biochem Biophys Res Commun , vol.297 , Issue.OCTOBER 4 , pp. 760-764
    • G-Amlak, M.1    Uddin, S.2    Mahmud, D.3    Damacela, I.4    Lavelle, D.5    Ahmed, M.6
  • 33
    • 55049086241 scopus 로고    scopus 로고
    • Growth control of multiple myeloma cells through inhibition of glycogen synthase kinase-3
    • Zhou Y., Uddin S., Zimmerman T., Kang J.A., Ulaszek J., Wickrema A. Growth control of multiple myeloma cells through inhibition of glycogen synthase kinase-3. Leuk Lymphoma 2008, 49(October (10)):1945-1953.
    • (2008) Leuk Lymphoma , vol.49 , Issue.OCTOBER 10 , pp. 1945-1953
    • Zhou, Y.1    Uddin, S.2    Zimmerman, T.3    Kang, J.A.4    Ulaszek, J.5    Wickrema, A.6
  • 35
    • 77957266735 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death
    • Piazza F., Manni S., Tubi L.Q., Montini B., Pavan L., Colpo A., et al. Glycogen synthase kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death. BMC Cancer 2010, 10:526.
    • (2010) BMC Cancer , vol.10 , pp. 526
    • Piazza, F.1    Manni, S.2    Tubi, L.Q.3    Montini, B.4    Pavan, L.5    Colpo, A.6
  • 36
    • 84859430011 scopus 로고    scopus 로고
    • Fbxw7alpha- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma
    • Busino L., Millman S.E., Scotto L., Kyratsous C.A., Basrur V., O'Connor O., et al. Fbxw7alpha- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol 2012, 14(April (4)):375-385.
    • (2012) Nat Cell Biol , vol.14 , Issue.APRIL 4 , pp. 375-385
    • Busino, L.1    Millman, S.E.2    Scotto, L.3    Kyratsous, C.A.4    Basrur, V.5    O'Connor, O.6
  • 37
    • 27744434628 scopus 로고    scopus 로고
    • Novel aspects of osteoclast activation and osteoblast inhibition in myeloma bone disease
    • Heider U., Hofbauer L.C., Zavrski I., Kaiser M., Jakob C., Sezer O. Novel aspects of osteoclast activation and osteoblast inhibition in myeloma bone disease. Biochem Biophys Res Commun 2005, 338(December (2)):687-693.
    • (2005) Biochem Biophys Res Commun , vol.338 , Issue.DECEMBER 2 , pp. 687-693
    • Heider, U.1    Hofbauer, L.C.2    Zavrski, I.3    Kaiser, M.4    Jakob, C.5    Sezer, O.6
  • 39
    • 77749270565 scopus 로고    scopus 로고
    • Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy
    • Krause U., Harris S., Green A., Ylostalo J., Zeitouni S., Lee N., et al. Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy. Proc Natl Acad Sci USA 2010, 107(March (9)):4147-4152.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.MARCH 9 , pp. 4147-4152
    • Krause, U.1    Harris, S.2    Green, A.3    Ylostalo, J.4    Zeitouni, S.5    Lee, N.6
  • 40
    • 79551617573 scopus 로고    scopus 로고
    • Pharmaceutical inhibition of glycogen synthetase kinase-3beta reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model
    • Gunn W.G., Krause U., Lee N., Gregory C.A. Pharmaceutical inhibition of glycogen synthetase kinase-3beta reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model. Blood 2011, 117(February (5)):1641-1651.
    • (2011) Blood , vol.117 , Issue.FEBRUARY 5 , pp. 1641-1651
    • Gunn, W.G.1    Krause, U.2    Lee, N.3    Gregory, C.A.4
  • 41
    • 78650321320 scopus 로고    scopus 로고
    • CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy
    • Siddiqui-Jain A., Drygin D., Streiner N., Chua P., Pierre F., O'Brien S.E., et al. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res 2010, 70(December (24)):10288-10298.
    • (2010) Cancer Res , vol.70 , Issue.DECEMBER 24 , pp. 10288-10298
    • Siddiqui-Jain, A.1    Drygin, D.2    Streiner, N.3    Chua, P.4    Pierre, F.5    O'Brien, S.E.6
  • 42
    • 84855253348 scopus 로고    scopus 로고
    • Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer
    • Pierre F., Chua P.C., O'Brien S.E., Siddiqui-Jain A., Bourbon P., Haddach M., et al. Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer. Mol Cell Biochem 2011, 356(October (1-2)):37-43.
    • (2011) Mol Cell Biochem , vol.356 , Issue.OCTOBER 1 2 , pp. 37-43
    • Pierre, F.1    Chua, P.C.2    O'Brien, S.E.3    Siddiqui-Jain, A.4    Bourbon, P.5    Haddach, M.6
  • 43
    • 84862737578 scopus 로고    scopus 로고
    • CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy
    • Siddiqui-Jain A., Bliesath J., Macalino D., Omori M., Huser N., Streiner N., et al. CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy. Mol Cancer Ther 2012, 11(April (4)):994-1005.
    • (2012) Mol Cancer Ther , vol.11 , Issue.APRIL 4 , pp. 994-1005
    • Siddiqui-Jain, A.1    Bliesath, J.2    Macalino, D.3    Omori, M.4    Huser, N.5    Streiner, N.6
  • 44
    • 33748299477 scopus 로고    scopus 로고
    • The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways
    • Beurel E., Jope R.S. The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol 2006, 79(July (4)):173-189.
    • (2006) Prog Neurobiol , vol.79 , Issue.JULY 4 , pp. 173-189
    • Beurel, E.1    Jope, R.S.2


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