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Volumn 25, Issue 2, 2013, Pages 135-145

Bisphosphonates in the Adjuvant Treatment of Breast Cancer

Author keywords

Adjuvant; Anti tumour activity; Bisphosphonates; Breast cancer; Clodronate; Zoledronic acid

Indexed keywords

ANASTROZOLE; AROMATASE INHIBITOR; BISPHOSPHONIC ACID DERIVATIVE; CAPECITABINE; CLODRONIC ACID; DENOSUMAB; IBANDRONIC ACID; LETROZOLE; PAMIDRONIC ACID; RISEDRONIC ACID; TAMOXIFEN; ZOLEDRONIC ACID;

EID: 84872395940     PISSN: 09366555     EISSN: 14332981     Source Type: Journal    
DOI: 10.1016/j.clon.2012.10.010     Document Type: Article
Times cited : (25)

References (68)
  • 2
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: causes, consequences and therapeutic opportunities
    • Mundy G.R. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2002, 2:584-593.
    • (2002) Nat Rev Cancer , vol.2 , pp. 584-593
    • Mundy, G.R.1
  • 3
    • 0034659773 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of action of bisphosphonates
    • Rogers M.J., Gordon S., Benford H.L., et al. Cellular and molecular mechanisms of action of bisphosphonates. Cancer 2000, 88:2961-2978.
    • (2000) Cancer , vol.88 , pp. 2961-2978
    • Rogers, M.J.1    Gordon, S.2    Benford, H.L.3
  • 4
    • 0033065233 scopus 로고    scopus 로고
    • Bisphosphonates: from the laboratory to the clinic and back again
    • Russell R.G., Rogers M.J. Bisphosphonates: from the laboratory to the clinic and back again. Bone 1999, 25:97-106.
    • (1999) Bone , vol.25 , pp. 97-106
    • Russell, R.G.1    Rogers, M.J.2
  • 5
    • 0032996153 scopus 로고    scopus 로고
    • Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs
    • Benford H.L., Frith J.C., Auriola S., Monkkonen J., Rogers M.J. Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. Mol Pharmacol 1999, 56:131-140.
    • (1999) Mol Pharmacol , vol.56 , pp. 131-140
    • Benford, H.L.1    Frith, J.C.2    Auriola, S.3    Monkkonen, J.4    Rogers, M.J.5
  • 6
    • 0031977199 scopus 로고    scopus 로고
    • Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
    • Luckman S.P., Hughes D.E., Coxon F.P., Graham R., Russell G., Rogers M.J. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 1998, 13:581-589.
    • (1998) J Bone Miner Res , vol.13 , pp. 581-589
    • Luckman, S.P.1    Hughes, D.E.2    Coxon, F.P.3    Graham, R.4    Russell, G.5    Rogers, M.J.6
  • 7
    • 84861691129 scopus 로고    scopus 로고
    • Cancer treatment-induced bone loss in premenopausal women: a need for therapeutic intervention?
    • Hadji P., Gnant M., Body J.J., et al. Cancer treatment-induced bone loss in premenopausal women: a need for therapeutic intervention?. Cancer Treat Rev 2012, 38(6):798-806.
    • (2012) Cancer Treat Rev , vol.38 , Issue.6 , pp. 798-806
    • Hadji, P.1    Gnant, M.2    Body, J.J.3
  • 8
    • 44649187408 scopus 로고    scopus 로고
    • Guidance for the management of breast cancer treatment-induced bone loss: a consensus position statement from a UK expert group
    • Reid D.M., Doughty J., Eastell R., et al. Guidance for the management of breast cancer treatment-induced bone loss: a consensus position statement from a UK expert group. Cancer Treat Rev 2008, 34(Suppl. 1):S3-18.
    • (2008) Cancer Treat Rev , vol.34 , Issue.SUPPL. 1
    • Reid, D.M.1    Doughty, J.2    Eastell, R.3
  • 9
    • 0029864362 scopus 로고    scopus 로고
    • Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer
    • Bines J., Oleske D.M., Cobleigh M.A. Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol 1996, 14:1718-1729.
    • (1996) J Clin Oncol , vol.14 , pp. 1718-1729
    • Bines, J.1    Oleske, D.M.2    Cobleigh, M.A.3
  • 10
    • 17444401018 scopus 로고    scopus 로고
    • The causes and treatment of bone loss associated with carcinoma of the breast
    • Lester J., Dodwell D., McCloskey E., Coleman R. The causes and treatment of bone loss associated with carcinoma of the breast. Cancer Treat Rev 2005, 31:115-142.
    • (2005) Cancer Treat Rev , vol.31 , pp. 115-142
    • Lester, J.1    Dodwell, D.2    McCloskey, E.3    Coleman, R.4
  • 11
    • 54249151531 scopus 로고    scopus 로고
    • Zoledronic acid prevents bone loss in premenopausal women undergoing adjuvant chemotherapy for early-stage breast cancer
    • Hershman D.L., McMahon D.J., Crew K.D., et al. Zoledronic acid prevents bone loss in premenopausal women undergoing adjuvant chemotherapy for early-stage breast cancer. J Clin Oncol 2008, 26:4739-4745.
    • (2008) J Clin Oncol , vol.26 , pp. 4739-4745
    • Hershman, D.L.1    McMahon, D.J.2    Crew, K.D.3
  • 12
    • 78651104412 scopus 로고    scopus 로고
    • Zoledronic acid prevents bone loss in premenopausal women with early breast cancer undergoing adjuvant chemotherapy: a phase III trial of the Korean Cancer Study Group (KCSG-BR06-01)
    • Kim J.E., Ahn J.H., Jung K.H., et al. Zoledronic acid prevents bone loss in premenopausal women with early breast cancer undergoing adjuvant chemotherapy: a phase III trial of the Korean Cancer Study Group (KCSG-BR06-01). Breast Cancer Res Treat 2011, 125:99-106.
    • (2011) Breast Cancer Res Treat , vol.125 , pp. 99-106
    • Kim, J.E.1    Ahn, J.H.2    Jung, K.H.3
  • 13
    • 79952101885 scopus 로고    scopus 로고
    • Zoledronic acid preserves bone mineral density in premenopausal women who develop ovarian failure due to adjuvant chemotherapy: final results from CALGB trial 79809
    • Shapiro C.L., Halabi S., Hars V., et al. Zoledronic acid preserves bone mineral density in premenopausal women who develop ovarian failure due to adjuvant chemotherapy: final results from CALGB trial 79809. Eur J Cancer 2011, 47:683-689.
    • (2011) Eur J Cancer , vol.47 , pp. 683-689
    • Shapiro, C.L.1    Halabi, S.2    Hars, V.3
  • 14
    • 61449227421 scopus 로고    scopus 로고
    • Phase III randomized, placebo-controlled, double-blind trial of risedronate for the prevention of bone loss in premenopausal women undergoing chemotherapy for primary breast cancer
    • Hines S.L., Mincey B.A., Sloan J.A., et al. Phase III randomized, placebo-controlled, double-blind trial of risedronate for the prevention of bone loss in premenopausal women undergoing chemotherapy for primary breast cancer. J Clin Oncol 2009, 27:1047-1053.
    • (2009) J Clin Oncol , vol.27 , pp. 1047-1053
    • Hines, S.L.1    Mincey, B.A.2    Sloan, J.A.3
  • 15
    • 49949115926 scopus 로고    scopus 로고
    • Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy
    • Gnant M., Mlineritsch B., Luschin-Ebengreuth G., et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy. Lancet Oncol 2008, 9:840-849.
    • (2008) Lancet Oncol , vol.9 , pp. 840-849
    • Gnant, M.1    Mlineritsch, B.2    Luschin-Ebengreuth, G.3
  • 16
    • 41949094767 scopus 로고    scopus 로고
    • Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230
    • Eastell R., Adams J.E., Coleman R.E., et al. Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230. J Clin Oncol 2008, 26:1051-1057.
    • (2008) J Clin Oncol , vol.26 , pp. 1051-1057
    • Eastell, R.1    Adams, J.E.2    Coleman, R.E.3
  • 17
    • 79953320008 scopus 로고    scopus 로고
    • Long-term effects of anastrozole on bone mineral density: 7-year results from the ATAC trial
    • Eastell R., Adams J., Clack G., et al. Long-term effects of anastrozole on bone mineral density: 7-year results from the ATAC trial. Ann Oncol 2010, 22:857-862.
    • (2010) Ann Oncol , vol.22 , pp. 857-862
    • Eastell, R.1    Adams, J.2    Clack, G.3
  • 18
    • 77957708501 scopus 로고    scopus 로고
    • Reversal of skeletal effects of endocrine treatments in the Intergroup Exemestane Study
    • Coleman R.E., Banks L.M., Girgis S.I., et al. Reversal of skeletal effects of endocrine treatments in the Intergroup Exemestane Study. Breast Cancer Res Treat 2010, 124:153-161.
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 153-161
    • Coleman, R.E.1    Banks, L.M.2    Girgis, S.I.3
  • 19
    • 80052826625 scopus 로고    scopus 로고
    • Management of aromatase inhibitor-associated bone loss in postmenopausal women with breast cancer: practical guidance for prevention and treatment
    • Hadji P., Aapro M.S., Body J.J., et al. Management of aromatase inhibitor-associated bone loss in postmenopausal women with breast cancer: practical guidance for prevention and treatment. Ann Oncol 2011, 22:2546-2555.
    • (2011) Ann Oncol , vol.22 , pp. 2546-2555
    • Hadji, P.1    Aapro, M.S.2    Body, J.J.3
  • 20
    • 33947524592 scopus 로고    scopus 로고
    • Zoledronic acid inhibits adjuvant letrozole-induced bone loss in postmenopausal women with early breast cancer
    • Brufsky A., Harker W.G., Beck J.T., et al. Zoledronic acid inhibits adjuvant letrozole-induced bone loss in postmenopausal women with early breast cancer. J Clin Oncol 2007, 25:829-836.
    • (2007) J Clin Oncol , vol.25 , pp. 829-836
    • Brufsky, A.1    Harker, W.G.2    Beck, J.T.3
  • 21
    • 39749155815 scopus 로고    scopus 로고
    • Effective inhibition of aromatase inhibitor-associated bone loss by zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: ZO-FAST Study results
    • Bundred N.J., Campbell I.D., Davidson N., et al. Effective inhibition of aromatase inhibitor-associated bone loss by zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: ZO-FAST Study results. Cancer 2008, 112:1001-1010.
    • (2008) Cancer , vol.112 , pp. 1001-1010
    • Bundred, N.J.1    Campbell, I.D.2    Davidson, N.3
  • 22
    • 84862926420 scopus 로고    scopus 로고
    • Immediate administration of zoledronic acid reduces aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer: 12-month analysis of the E-ZO-FAST trial
    • Llombart A., Frassoldati A., Paija O., et al. immediate administration of zoledronic acid reduces aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer: 12-month analysis of the E-ZO-FAST trial. Clin Breast Cancer 2012, 12:40-48.
    • (2012) Clin Breast Cancer , vol.12 , pp. 40-48
    • Llombart, A.1    Frassoldati, A.2    Paija, O.3
  • 23
    • 70349571180 scopus 로고    scopus 로고
    • Immediate versus delayed zoledronic acid for prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen-N03CC
    • Hines S.L., Mincey B., Dentchev T., et al. Immediate versus delayed zoledronic acid for prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen-N03CC. Breast Cancer Res Treat 2009, 117:603-609.
    • (2009) Breast Cancer Res Treat , vol.117 , pp. 603-609
    • Hines, S.L.1    Mincey, B.2    Dentchev, T.3
  • 24
    • 84872386871 scopus 로고    scopus 로고
    • Zoledronic acid prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: E-ZO-FAST 36 month follow-up. American Society of Clinical Oncology Breast Cancer Symposium Abstract 213. San Francisco
    • Llombart A, Frassoldati A, Paija O. Zoledronic acid prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: E-ZO-FAST 36 month follow-up. American Society of Clinical Oncology Breast Cancer Symposium Abstract 213. San Francisco, 2009.
    • (2009)
    • Llombart, A.1    Frassoldati, A.2    Paija, O.3
  • 25
    • 84857370664 scopus 로고    scopus 로고
    • Final 5-year results of Z-FAST trial: adjuvant zoledronic acid maintains bone mass in postmenopausal breast cancer patients receiving letrozole
    • Brufsky A.M., Harker W.G., Beck J.T., et al. Final 5-year results of Z-FAST trial: adjuvant zoledronic acid maintains bone mass in postmenopausal breast cancer patients receiving letrozole. Cancer 2012, 118:1192-1201.
    • (2012) Cancer , vol.118 , pp. 1192-1201
    • Brufsky, A.M.1    Harker, W.G.2    Beck, J.T.3
  • 26
    • 84872393734 scopus 로고    scopus 로고
    • The effect of zoledronic acid on aromatase-inhibitor associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: the ZO-FAST study 5-year final follow-up
    • abstract P5-11-01
    • De Boer R., Bundred N., Eidtmann H., et al. The effect of zoledronic acid on aromatase-inhibitor associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: the ZO-FAST study 5-year final follow-up. Cancer Res 2011, 70(24 Suppl.). abstract P5-11-01.
    • (2011) Cancer Res , vol.70 , Issue.24 SUPPL.
    • De Boer, R.1    Bundred, N.2    Eidtmann, H.3
  • 27
    • 58149166777 scopus 로고    scopus 로고
    • Prevention of anastrozole-induced bone loss with monthly oral ibandronate during adjuvant aromatase inhibitor therapy for breast cancer
    • Lester J.E., Dodwell D., Purohit O.P., et al. Prevention of anastrozole-induced bone loss with monthly oral ibandronate during adjuvant aromatase inhibitor therapy for breast cancer. Clin Cancer Res 2008, 14:6336-6342.
    • (2008) Clin Cancer Res , vol.14 , pp. 6336-6342
    • Lester, J.E.1    Dodwell, D.2    Purohit, O.P.3
  • 28
    • 77956636088 scopus 로고    scopus 로고
    • Management of anastrozole-induced bone loss in breast cancer patients with oral risedronate: results from the ARBI prospective clinical trial
    • Markopoulos C., Tzoracoleftherakis E., Polychronis A., et al. Management of anastrozole-induced bone loss in breast cancer patients with oral risedronate: results from the ARBI prospective clinical trial. Breast Cancer Res 2010, 12:R24.
    • (2010) Breast Cancer Res , vol.12
    • Markopoulos, C.1    Tzoracoleftherakis, E.2    Polychronis, A.3
  • 29
    • 77949900992 scopus 로고    scopus 로고
    • Prevention of aromatase inhibitor-induced bone loss using risedronate: the SABRE trial
    • Van Poznak C., Hannon R.A., Mackey J.R., et al. Prevention of aromatase inhibitor-induced bone loss using risedronate: the SABRE trial. J Clin Oncol 2010, 28:967-975.
    • (2010) J Clin Oncol , vol.28 , pp. 967-975
    • Van Poznak, C.1    Hannon, R.A.2    Mackey, J.R.3
  • 30
    • 46849110780 scopus 로고    scopus 로고
    • Practical guidance for the management of aromatase inhibitor-associated bone loss
    • Hadji P., Body J.J., Aapro M.S., et al. Practical guidance for the management of aromatase inhibitor-associated bone loss. Ann Oncol 2008, 19:1407-1416.
    • (2008) Ann Oncol , vol.19 , pp. 1407-1416
    • Hadji, P.1    Body, J.J.2    Aapro, M.S.3
  • 31
    • 46949100735 scopus 로고    scopus 로고
    • Exploring the anti-tumour activity of bisphosphonates in early breast cancer
    • Winter M.C., Holen I., Coleman R.E. Exploring the anti-tumour activity of bisphosphonates in early breast cancer. Cancer Treat Rev 2008, 34:453-475.
    • (2008) Cancer Treat Rev , vol.34 , pp. 453-475
    • Winter, M.C.1    Holen, I.2    Coleman, R.E.3
  • 32
    • 33847771427 scopus 로고    scopus 로고
    • Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis
    • Daubine F., Le Gall C., Gasser J., Green J., Clezardin P. Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis. J Natl Cancer Inst 2007, 99:322-330.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 322-330
    • Daubine, F.1    Le Gall, C.2    Gasser, J.3    Green, J.4    Clezardin, P.5
  • 33
    • 0029101805 scopus 로고
    • Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice
    • Sasaki A., Boyce B.F., Story B., et al. Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice. Cancer Res 1995, 55:3551-3557.
    • (1995) Cancer Res , vol.55 , pp. 3551-3557
    • Sasaki, A.1    Boyce, B.F.2    Story, B.3
  • 34
    • 0031806712 scopus 로고    scopus 로고
    • Effect of a newly developed bisphosphonate, YH529, on osteolytic bone metastases in nude mice
    • Sasaki A., Kitamura K., Alcalde R.E., et al. Effect of a newly developed bisphosphonate, YH529, on osteolytic bone metastases in nude mice. Int J Cancer 1998, 77:279-285.
    • (1998) Int J Cancer , vol.77 , pp. 279-285
    • Sasaki, A.1    Kitamura, K.2    Alcalde, R.E.3
  • 35
    • 3042729728 scopus 로고    scopus 로고
    • Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model
    • Hiraga T., Williams P.J., Ueda A., Tamura D., Yoneda T. Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model. Clin Cancer Res 2004, 10:4559-4567.
    • (2004) Clin Cancer Res , vol.10 , pp. 4559-4567
    • Hiraga, T.1    Williams, P.J.2    Ueda, A.3    Tamura, D.4    Yoneda, T.5
  • 36
    • 73549086519 scopus 로고    scopus 로고
    • Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model
    • Ottewell P.D., Lefley D.V., Cross S.S., Evans C.A., Coleman R.E., Holen I. Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model. Int J Cancer 2009, 126(2):522-532.
    • (2009) Int J Cancer , vol.126 , Issue.2 , pp. 522-532
    • Ottewell, P.D.1    Lefley, D.V.2    Cross, S.S.3    Evans, C.A.4    Coleman, R.E.5    Holen, I.6
  • 37
    • 51049114468 scopus 로고    scopus 로고
    • Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer
    • Ottewell P.D., Monkkonen H., Jones M., Lefley D.V., Coleman R.E., Holen I. Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer. J Natl Cancer Inst 2008, 100:1167-1178.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1167-1178
    • Ottewell, P.D.1    Monkkonen, H.2    Jones, M.3    Lefley, D.V.4    Coleman, R.E.5    Holen, I.6
  • 38
    • 0141567513 scopus 로고    scopus 로고
    • Induction of gammadelta T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo
    • Dieli F., Gebbia N., Poccia F., et al. Induction of gammadelta T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo. Blood 2003, 102:2310-2311.
    • (2003) Blood , vol.102 , pp. 2310-2311
    • Dieli, F.1    Gebbia, N.2    Poccia, F.3
  • 39
    • 0034660687 scopus 로고    scopus 로고
    • Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma
    • Kunzmann V., Bauer E., Feurle J., Weissinger F., Tony H.P., Wilhelm M. Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma. Blood 2000, 96:384-392.
    • (2000) Blood , vol.96 , pp. 384-392
    • Kunzmann, V.1    Bauer, E.2    Feurle, J.3    Weissinger, F.4    Tony, H.P.5    Wilhelm, M.6
  • 40
    • 77952305169 scopus 로고    scopus 로고
    • Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial
    • Aft R., Naughton M., Trinkaus K., et al. Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial. Lancet Oncol 2010, 11:421-428.
    • (2010) Lancet Oncol , vol.11 , pp. 421-428
    • Aft, R.1    Naughton, M.2    Trinkaus, K.3
  • 41
    • 77954572691 scopus 로고    scopus 로고
    • Effect of zoledronate on persisting isolated tumour cells in patients with early breast cancer
    • Rack B., Juckstock J., Genss E.M., et al. Effect of zoledronate on persisting isolated tumour cells in patients with early breast cancer. Anticancer Res 2010, 30:1807-1813.
    • (2010) Anticancer Res , vol.30 , pp. 1807-1813
    • Rack, B.1    Juckstock, J.2    Genss, E.M.3
  • 42
    • 84864317505 scopus 로고    scopus 로고
    • Influence of zoledronic acid on disseminated tumor cells in primary breast cancer patients
    • Solomayer E.F., Gebauer G., Hirnle P., et al. Influence of zoledronic acid on disseminated tumor cells in primary breast cancer patients. Ann Oncol 2012, 23(9):2271-2277.
    • (2012) Ann Oncol , vol.23 , Issue.9 , pp. 2271-2277
    • Solomayer, E.F.1    Gebauer, G.2    Hirnle, P.3
  • 43
    • 56749165071 scopus 로고    scopus 로고
    • Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up
    • Diel I.J., Jaschke A., Solomayer E.F., et al. Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up. Ann Oncol 2008, 19:2007-2011.
    • (2008) Ann Oncol , vol.19 , pp. 2007-2011
    • Diel, I.J.1    Jaschke, A.2    Solomayer, E.F.3
  • 44
    • 0032491037 scopus 로고    scopus 로고
    • Reduction in new metastases in breast cancer with adjuvant clodronate treatment
    • Diel I.J., Solomayer E.F., Costa S.D., et al. Reduction in new metastases in breast cancer with adjuvant clodronate treatment. N Engl J Med 1998, 339:357-363.
    • (1998) N Engl J Med , vol.339 , pp. 357-363
    • Diel, I.J.1    Solomayer, E.F.2    Costa, S.D.3
  • 45
    • 33744828376 scopus 로고    scopus 로고
    • Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]
    • Powles T., Paterson A., McCloskey E., et al. Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]. Breast Cancer Res 2006, 8:R13.
    • (2006) Breast Cancer Res , vol.8
    • Powles, T.1    Paterson, A.2    McCloskey, E.3
  • 46
    • 0036682211 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer
    • Powles T., Paterson S., Kanis J.A., et al. Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer. J Clin Oncol 2002, 20:3219-3224.
    • (2002) J Clin Oncol , vol.20 , pp. 3219-3224
    • Powles, T.1    Paterson, S.2    Kanis, J.A.3
  • 47
    • 0035148170 scopus 로고    scopus 로고
    • Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial
    • Saarto T., Blomqvist C., Virkkunen P., Elomaa I. Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial. J Clin Oncol 2001, 19:10-17.
    • (2001) J Clin Oncol , vol.19 , pp. 10-17
    • Saarto, T.1    Blomqvist, C.2    Virkkunen, P.3    Elomaa, I.4
  • 48
    • 9444254706 scopus 로고    scopus 로고
    • Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patients
    • Saarto T., Vehmanen L., Virkkunen P., Blomqvist C. Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patients. Acta Oncol 2004, 43:650-656.
    • (2004) Acta Oncol , vol.43 , pp. 650-656
    • Saarto, T.1    Vehmanen, L.2    Virkkunen, P.3    Blomqvist, C.4
  • 49
    • 34250326616 scopus 로고    scopus 로고
    • Meta-analysis of clodronate and breast cancer survival
    • Ha T.C., Li H. Meta-analysis of clodronate and breast cancer survival. Br J Cancer 2007, 96:1796-1801.
    • (2007) Br J Cancer , vol.96 , pp. 1796-1801
    • Ha, T.C.1    Li, H.2
  • 50
    • 45149083364 scopus 로고    scopus 로고
    • Bisphosphonate treatment in primary breast cancer: results from a randomised comparison of oral pamidronate versus no pamidronate in patients with primary breast cancer
    • Kristensen B., Ejlertsen B., Mouridsen H.T., et al. Bisphosphonate treatment in primary breast cancer: results from a randomised comparison of oral pamidronate versus no pamidronate in patients with primary breast cancer. Acta Oncol 2008, 47:740-746.
    • (2008) Acta Oncol , vol.47 , pp. 740-746
    • Kristensen, B.1    Ejlertsen, B.2    Mouridsen, H.T.3
  • 51
    • 84863109831 scopus 로고    scopus 로고
    • Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial
    • Paterson A.H., Anderson S.J., Lembersky B.C., et al. Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial. Lancet Oncol 2012, 13(7):734-742.
    • (2012) Lancet Oncol , vol.13 , Issue.7 , pp. 734-742
    • Paterson, A.H.1    Anderson, S.J.2    Lembersky, B.C.3
  • 52
    • 84864486923 scopus 로고    scopus 로고
    • GAIN study: a phase III trial to compare ETC vs. EC-TX and ibandronate vs. observation in patients with node-positive primary breast cancer - 1st interim efficacy analysis
    • abstract S2-S4
    • Mobus V., Diel I.J., Elling D., et al. GAIN study: a phase III trial to compare ETC vs. EC-TX and ibandronate vs. observation in patients with node-positive primary breast cancer - 1st interim efficacy analysis. Cancer Res 2011, 71(24 Suppl.). abstract S2-S4.
    • (2011) Cancer Res , vol.71 , Issue.24 SUPPL.
    • Mobus, V.1    Diel, I.J.2    Elling, D.3
  • 53
    • 60549097419 scopus 로고    scopus 로고
    • Endocrine therapy plus zoledronic acid in premenopausal breast cancer
    • Gnant M., Mlineritsch B., Schippinger W., et al. Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N Engl J Med 2009, 360:679-691.
    • (2009) N Engl J Med , vol.360 , pp. 679-691
    • Gnant, M.1    Mlineritsch, B.2    Schippinger, W.3
  • 54
    • 79959565208 scopus 로고    scopus 로고
    • Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial
    • Gnant M., Mlineritsch B., Stoeger H., et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncol 2011, 12:631-641.
    • (2011) Lancet Oncol , vol.12 , pp. 631-641
    • Gnant, M.1    Mlineritsch, B.2    Stoeger, H.3
  • 55
    • 84863108849 scopus 로고    scopus 로고
    • Long-term follow-up in ABCSG-12: significantly improved overall survival with adjuvant zoledronic acid in pre-menopausal patients with endocrine-receptor-positive early breast cancer
    • abstract S1-S2
    • Gnant M., Mlineritsch B., Luschin-Ebengreuth G., et al. Long-term follow-up in ABCSG-12: significantly improved overall survival with adjuvant zoledronic acid in pre-menopausal patients with endocrine-receptor-positive early breast cancer. Cancer Res 2011, 71(24 Suppl.). abstract S1-S2.
    • (2011) Cancer Res , vol.71 , Issue.24 SUPPL.
    • Gnant, M.1    Mlineritsch, B.2    Luschin-Ebengreuth, G.3
  • 56
    • 84863090684 scopus 로고    scopus 로고
    • Long-term survival outcome among post-menopausal women with hormone receptor-positive early breast cancer receiving adjuvant letrozole and zoledronic acid; 5-year follow-up of ZO-FAST
    • abstract S1-S3
    • de Boer R., Bundred N., Eidtmann H., et al. Long-term survival outcome among post-menopausal women with hormone receptor-positive early breast cancer receiving adjuvant letrozole and zoledronic acid; 5-year follow-up of ZO-FAST. Cancer Res 2011, 71(24 Suppl.). abstract S1-S3.
    • (2011) Cancer Res , vol.71 , Issue.24 SUPPL.
    • de Boer, R.1    Bundred, N.2    Eidtmann, H.3
  • 57
    • 84872376243 scopus 로고    scopus 로고
    • The effect of zoledronic acid on aromatase inhibitor-associated bone loss in post-menopausal women with early breast cancer receiving adjuvant letrozole: the Z-FAST study 5-year final follow-up. Presented at the 2009 San Antonio Breast Cancer Symposium Abstract 4083
    • Brufsky A, Harker WG, Beck JT, et al. The effect of zoledronic acid on aromatase inhibitor-associated bone loss in post-menopausal women with early breast cancer receiving adjuvant letrozole: the Z-FAST study 5-year final follow-up. Presented at the 2009 San Antonio Breast Cancer Symposium Abstract 4083, 2009.
    • (2009)
    • Brufsky, A.1    Harker, W.G.2    Beck, J.T.3
  • 58
    • 84872382091 scopus 로고    scopus 로고
    • Impact of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant zoledronic acid: Z-FAST, ZO-FAST and EZO-FAST. San Antonio Breast Cancer Symposium, 2009, abstract 4082, San Antonio, TX
    • Coleman RE, Bundred N, De Boer R, et al. Impact of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant zoledronic acid: Z-FAST, ZO-FAST and EZO-FAST. San Antonio Breast Cancer Symposium, 2009, abstract 4082, San Antonio, TX, 2009.
    • (2009)
    • Coleman, R.E.1    Bundred, N.2    De Boer, R.3
  • 59
    • 80054035939 scopus 로고    scopus 로고
    • Breast-cancer adjuvant therapy with zoledronic acid
    • Coleman R.E., Marshall H., Cameron D., et al. Breast-cancer adjuvant therapy with zoledronic acid. N Engl J Med 2011, 365:1396-1405.
    • (2011) N Engl J Med , vol.365 , pp. 1396-1405
    • Coleman, R.E.1    Marshall, H.2    Cameron, D.3
  • 60
    • 79958182699 scopus 로고    scopus 로고
    • Safety of zoledronic acid and incidence of osteonecrosis of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE: BIG 01-04) for women with stage II/III breast cancer
    • Coleman R., Woodward E., Brown J., et al. Safety of zoledronic acid and incidence of osteonecrosis of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE: BIG 01-04) for women with stage II/III breast cancer. Breast Cancer Res Treat 2011, 127:429-438.
    • (2011) Breast Cancer Res Treat , vol.127 , pp. 429-438
    • Coleman, R.1    Woodward, E.2    Brown, J.3
  • 61
    • 84872385343 scopus 로고    scopus 로고
    • Adjuvant zoledronic acid (ZOL) in postmenopausal women with breast cancer and those rendered postmenopausal: results of a meta-analysis
    • abstract 513
    • Gregory W., Marshall H., Bell R., Cameron D.A., Coleman R.E. Adjuvant zoledronic acid (ZOL) in postmenopausal women with breast cancer and those rendered postmenopausal: results of a meta-analysis. J Clin Oncol 2012, 30(Suppl.). abstract 513.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Gregory, W.1    Marshall, H.2    Bell, R.3    Cameron, D.A.4    Coleman, R.E.5
  • 62
    • 84863107789 scopus 로고    scopus 로고
    • Seed, soil and secreted hormones: potential interactions of breast cancer cells with their endocrine/paracrine microenvironment and implications for treatment with bisphosphonates
    • Wilson C., Holen I., Coleman R.E. Seed, soil and secreted hormones: potential interactions of breast cancer cells with their endocrine/paracrine microenvironment and implications for treatment with bisphosphonates. Cancer Treat Rev 2012, 38(7):877-889.
    • (2012) Cancer Treat Rev , vol.38 , Issue.7 , pp. 877-889
    • Wilson, C.1    Holen, I.2    Coleman, R.E.3
  • 63
    • 34848841461 scopus 로고    scopus 로고
    • Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research
    • Khosla S., Burr D., Cauley J., et al. Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 2007, 22:1479-1491.
    • (2007) J Bone Miner Res , vol.22 , pp. 1479-1491
    • Khosla, S.1    Burr, D.2    Cauley, J.3
  • 65
    • 44449153039 scopus 로고    scopus 로고
    • Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates
    • Hoff A.O., Toth B.B., Altundag K., et al. Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Miner Res 2008, 23:826-836.
    • (2008) J Bone Miner Res , vol.23 , pp. 826-836
    • Hoff, A.O.1    Toth, B.B.2    Altundag, K.3
  • 66
    • 84872397620 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence. Denosumab for the prevention of skeletal-related events in adults with bone metastases from solid tumours. NICE technology appraisal guidance 265. [accessed 13.11.12].
    • National Institute for Health and Clinical Excellence. Denosumab for the prevention of skeletal-related events in adults with bone metastases from solid tumours. NICE technology appraisal guidance 265. [accessed 13.11.12]. http://guidance.nice.org.uk/265.
  • 67
    • 84872397673 scopus 로고    scopus 로고
    • Study to determine treatment effects of denosumab in patients with breast cancer receiving aromatase inhibitor therapy. [accessed 17.09.12]. ctgov:NCT00556374
    • Study to determine treatment effects of denosumab in patients with breast cancer receiving aromatase inhibitor therapy. [accessed 17.09.12]. ctgov:NCT00556374.
  • 68
    • 84872380504 scopus 로고    scopus 로고
    • Study of denosumab as adjuvant treatment for women with high risk early breast cancer receiving neoadjuvant or adjuvant therapy (D-CARE). [accessed 17.09.12].ctgov:NCT01077154
    • Study of denosumab as adjuvant treatment for women with high risk early breast cancer receiving neoadjuvant or adjuvant therapy (D-CARE). [accessed 17.09.12]. ctgov:NCT01077154.


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