Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 304, Issue 2, 2013, Pages

  Pabbidi, Mallikarjuna R ^c   Juncos, Julio ^c   Juncos, Luis ^c   Renic, Marija ^b   Tullos, Hurtis J ^c   Lazar, Jozeph ^b   Jacob, Howard J ^a,b   Harder, David R ^b   Roman, Richard J ^c  

^a Human and Molecular Genetics Center   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Autoregulation of CBF; Cerebral blood flow; Ischemic stroke; Middle cerebral artery; T MCAO

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOREGULATION; BLOOD VESSEL REACTIVITY; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN REGION; CHROMOSOME 1; CONTROLLED STUDY; FAWN HOODED HYPERTENSIVE RAT; HYPEREMIA; ISCHEMIA; MALE; MIDDLE CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, CONGENIC; BLOOD PRESSURE; BRAIN EDEMA; CEREBROVASCULAR CIRCULATION; CHROMOSOMES, MAMMALIAN; DISEASE MODELS, ANIMAL; GENE TRANSFER TECHNIQUES; GENETIC PREDISPOSITION TO DISEASE; HOMEOSTASIS; HYPERTENSION; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MIDDLE CEREBRAL ARTERY; MUSCLE, SMOOTH, VASCULAR; PHENOTYPE; RATS; RATS, INBRED BN; REPERFUSION INJURY;

EID: 84872388133     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00622.2012     Document Type: Article

References (32)

1. Bianchi G, Tripodi G, Casari G, Salardi S, Barber BR, Garcia R, Leoni P, Torielli L, Cusi D, Ferrandi M, Pinna LA, Baralle FE, Ferrari P. Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci USA 91: 3999-4003, 1994.
2. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genet 12: 44-51, 1996.
3. Davis MJ, Hill MA. Signaling mechanisms underlying the vascular myogenic response. Physiol Rev 79: 387-423, 1999.
4. de la Torre JC. Cerebromicrovascular pathology in Alzheimer's disease compared to normal aging. Gerontology 43: 26-43, 1997.
5. +-ATPase trafficking in response to GPCR signals and intracellular sodium. Circ Res 95: 1100-1108, 2004.
6. Faraci FM, Baumbach GL, Heistad DD. Cerebral circulation: humoral regulation and effects of chronic hypertension. J Am Soc Nephrol 1: 53-57, 1990.
7. Faraci FM, Mayhan WG, Heistad DD. Segmental vascular responses to acute hypertension in cerebrum and brain stem. Am J Physiol Heart Circ Physiol 252: H738-H742, 1987.
8. Faraci FM, Sobey CG. Role of potassium channels in regulation of cerebral vascular tone. J Cereb Blood Flow Metab 18: 1047-1063, 1998.
9. Gardner K, Bennett V. A new erythrocyte membrane-associated protein with calmodulin binding activity. Identification and purification. J Biol Chem 261: 1339-1348, 1986.
10. Joshi R, Bennett V. Mapping the domain structure of human erythrocyte adducin. J Biol Chem 265: 13130-13136, 1990.
11. Kuijpers MH, Gruys E. Spontaneous hypertension and hypertensive renal disease in the fawn-hooded rat. Br J Exp Pathol 65: 181-190, 1984.
12. Lange A, Gebremedhin D, Narayanan J, Harder D. 20-Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C. J Biol Chem 272: 27345-27352, 1997.
13. Li Y, Zagato L, Kuznetsova T, Tripodi G, Zerbini G, Richart T, Thijs L, Manunta P, Wang JG, Bianchi G, Staessen JA. Angiotensinconverting enzyme I/D and alpha-adducin Gly460Trp polymorphisms: from angiotensin-converting enzyme activity to cardiovascular outcome. Hypertension 49: 1291-1297, 2007.
14. Lopez B, Ryan RP, Moreno C, Sarkis A, Lazar J, Provoost AP, Jacob HJ, Roman RJ. Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats. Am J Physiol Renal Physiol 290: F1213-F1221, 2006.
15. Lountos GT, Tropea JE, Cherry S, Waugh DS. Overproduction, purification and structure determination of human dual-specificity phosphatase 14. Acta Crystallogr D Biol Crystallogr 65: 1013-1020, 2009.
16. Matsuoka Y, Hughes CA, Bennett V. Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. J Biol Chem 271: 25157-25166, 1996.
17. Matsuoka Y, Li X, Bennett V. Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. J Cell Biol 142: 485-497, 1998.
18. Murphy TV, Spurrell BE, Hill MA. Cellular signalling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways. Clin Exp Pharmacol Physiol 29: 612-619, 2002.
19. Nagasawa H, Kogure K. Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion. Stroke 20: 1037-1043, 1989.
20. Ochodnicky P, Henning RH, Buikema HJ, de Zeeuw D, Provoost AP, van Dokkum RP. Renal vascular dysfunction precedes the development of renal damage in the hypertensive Fawn-Hooded rat. Am J Physiol Renal Physiol 298: F625-F633, 2010.
21. Omura T, Tanaka Y, Miyata N, Koizumi C, Sakurai T, Fukasawa M, Hachiuma K, Minagawa T, Susumu T, Yoshida S, Nakaike S, Okuyama S, Harder DR, Roman RJ. Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. Stroke 37: 1307-1313, 2006.
22. Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev 2: 161-192, 1990.
23. Rudofsky UH, Magro AM. Spontaneous hypertension in fawn-hooded rats. Lab Anim Sci 32: 389-391, 1982.
24. Strandgaard S. Cerebral blood flow in the elderly: impact of hypertension and antihypertensive treatment. Cardiovasc Drugs Ther 4, Suppl 6: 1217-1221, 1991.
25. Tibbles LA, Woodgett JR. The stress-activated protein kinase pathways. Cell Mol Life Sci 55: 1230-1254, 1999.
26. Tripodi G, Piscone A, Borsani G, Tisminetzky S, Salardi S, Sidoli A, James P, Pongor S, Bianchi G, Baralle FE. Molecular cloning of an adducin-like protein: evidence of a polymorphism in the normotensive and hypertensive rats of the Milan strain. Biochem Biophys Res Commun 177: 939-947, 1991.
27. Tripodi G, Szpirer C, Reina C, Szpirer J, Bianchi G. Polymorphism of gamma-adducin gene in genetic hypertension and mapping of the gene to rat chromosome 1q55. Biochem Biophys Res Commun 237: 685-689, 1997.
28. Tripodi G, Valtorta F, Torielli L, Chieregatti E, Salardi S, Trusolino L, Menegon A, Ferrari P, Marchisio PC, Bianchi G. Hypertensionassociated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport. J Clin Invest 97: 2815-2822, 1996.
29. Van Dokkum RP, Alonso-Galicia M, Provoost AP, Jacob HJ, Roman RJ. Impaired autoregulation of renal blood flow in the fawn-hooded rat. Am J Physiol Regul Integr Comp Physiol 276: R189-R196, 1999.
30. van Dokkum RP, Sun CW, Provoost AP, Jacob HJ, Roman RJ. Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat. Am J Physiol Regul Integr Comp Physiol 276: R855-R863, 1999.
31. Williams JM, Burke M, Lazar J, Jacob HJ, Roman RJ. Temporal characterization of the development of renal injury in FHH rats and FHH.1BN congenic strains. Am J Physiol Renal Physiol 300: F330-F338, 2011.
32. Zagato L, Modica R, Florio M, Torielli L, Bihoreau MT, Bianchi G, Tripodi G. Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats. Hypertension 36: 734-739, 2000.