Androgen receptor primes prostate cancer cells to apoptosis through down-regulation of basal p21 expression

Biochemical and Biophysical Research Communications

Volumn 430, Issue 1, 2013, Pages 289-293

  Lin, Yuting ^a   Lu, Ziyan ^a   Kokontis, John ^b   Xiang, Jialing ^a  

^a Illinois Institute of Technology   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Androgen receptor; Apoptosis; P21; P53; PIRH2; Prostate cancer

Indexed keywords

AMINO TERMINAL TELOPEPTIDE; ANDROGEN RECEPTOR; PROTEIN P21; PROTEIN P53; PROTEIN PIRH2; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LENTIVIRINAE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RNA INTERFERENCE; ULTRAVIOLET RADIATION;

APOPTOSIS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; PROSTATIC NEOPLASMS; PROTEOLYSIS; RECEPTORS, ANDROGEN; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; ULTRAVIOLET RAYS;

EID: 84872384319     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.10.135     Document Type: Article

References (34)

1. Chang C., Kokontis J., Swift S., Liao S.T. Molecular cloning and structural analysis of complementary DNA of human and rat androgen receptors. Prog. Clin. Biol. Res. 1990, 322:53-63.
2. Chang C.S., Kokontis J., Liao S.T. Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors. Proc. Natl. Acad. Sci. USA 1988, 85:7211-7215.
3. Lavery D.N., McEwan I.J. Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations. Biochem. J. 2005, 391:449-464.
4. Gioeli D., Ficarro S.B., Kwiek J.J., Aaronson D., Hancock M., Catling A.D., White F.M., Christian R.E., Settlage R.E., Shabanowitz J., Hunt D.F., Weber M.J. Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J. Biol. Chem. 2002, 277:29304-29314.
5. Poukka H., Karvonen U., Janne O.A., Palvimo J.J. Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1). Proc. Natl. Acad. Sci. USA 2000, 97:14145-14150.
6. L. Beitel, Androgen Receptor Interacting Proteins and Coregulators Table, 2010. http://androgendb.mcgill.ca/ARinteract.pdf.
7. Leng R.P., Lin Y., Ma W., Wu H., Lemmers B., Chung S., Parant J.M., Lozano G., Hakem R., Benchimol S. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell 2003, 112:779-791.
8. Beitel L.K., Elhaji Y.A., Lumbroso R., Wing S.S., Panet-Raymond V., Gottlieb B., Pinsky L., Trifiro M.A. Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity. J. Mol. Endocrinol. 2002, 29:41-60.
9. Kokontis J.M., Hsu S., Chuu C.P., Dang M., Fukuchi J., Hiipakka R.A., Liao S. Role of androgen receptor in the progression of human prostate tumor cells to androgen independence and insensitivity. Prostate 2005, 65:287-298.
10. Isaacs J.T. Apoptosis: translating theory to therapy for prostate cancer. J. Natl. Cancer Inst. 2000, 92:1367-1369.
11. Heisler L.E., Evangelou A., Lew A.M., Trachtenberg J., Elsholtz H.P., Brown T.J. Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor. Mol. Cell Endocrinol. 1997, 126:59-73.
12. Debes J.D., Tindall D.J. The role of androgens and the androgen receptor in prostate cancer. Cancer Lett. 2002, 187:1-7.
13. Tang F., Kokontis J., Lin Y., Liao S., Lin A., Xiang J. Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis. J. Biol. Chem. 2009, 284:32353-32358.
14. Lin Y., Kokontis J., Tang F., Godfrey B., Liao S., Lin A., Chen Y., Xiang J. Androgen and its receptor promote Bax-mediated apoptosis. Mol. Cell Biol. 2006, 26:1908-1916.
15. Yeh S., Hu Y.C., Rahman M., Lin H.K., Hsu C.L., Ting H.J., Kang H.Y., Chang C. Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells. Proc. Natl. Acad. Sci. USA 2000, 97:11256-11261.
16. Godfrey B., Lin Y., Larson J., Haferkamp B., Xiang J. Proteasomal degradation unleashes the pro-death activity of androgen receptor. Cell Res. 2010, 20:1138-1147.
17. Jung Y.S., Qian Y., Chen X. Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy. FEBS Lett. 2012, 586:1397-1402.
18. Jung Y.S., Hakem A., Hakem R., Chen X. Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Mol. Cell Biol. 2012, 31:3997-4006.
19. Logan I.R., Gaughan L., McCracken S.R., Sapountzi V., Leung H.Y., Robson C.N. Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer. Mol. Cell Biol. 2006, 26:6502-6510.
20. Hattori T., Isobe T., Abe K., Kikuchi H., Kitagawa K., Oda T., Uchida C., Kitagawa M. Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1. Cancer Res. 2007, 67:10789-10795.
21. Jung Y.S., Qian Y., Chen X. The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation. J. Biol. Chem. 2011, 286:35388-35395.
22. Gartel A.L., Tyner A.L. Transcriptional regulation of the p21((WAF1/CIP1)) gene. Exp. Cell Res. 1999, 246:280-289.
23. Gartel A.L., Tyner A.L. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol. Cancer Ther. 2002, 1:639-649.
24. Reinke V., Lozano G. Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest. Radiat. Res. 1997, 148:115-122.
25. Murray S.A., Zheng H., Gu L., Jim Xiao Z.X. IGF-1 activates p21 to inhibit UV-induced cell death. Oncogene 2003, 22:1703-1711.
26. Rieber M., Strasberg Rieber M. Apoptosis-inducing levels of UV radiation and proteasome inhibitors produce opposite effects on p21(WAF1) in human melanoma cells. Int. J. Cancer 2000, 86:462-467.
27. Soria G., Podhajcer O., Prives C., Gottifredi V. P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation. Oncogene 2006, 25:2829-2838.
28. Abbas T., Sivaprasad U., Terai K., Amador V., Pagano M., Dutta A. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev. 2008, 22:2496-2506.
29. Bornstein G., Bloom J., Sitry-Shevah D., Nakayama K., Pagano M., Hershko A. Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J. Biol. Chem. 2003, 278:25752-25757.
30. Xiang J., Chao D.T., Korsmeyer S.J. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc. Natl. Acad. Sci. USA 1996, 93:14559-14563.
31. Stewart S.A., Dykxhoorn D.M., Palliser D., Mizuno H., Yu E.Y., An D.S., Sabatini D.M., Chen I.S., Hahn W.C., Sharp P.A., Weinberg R.A., Novina C.D. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 2003, 9:493-501.
32. Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., Sedivy J.M., Kinzler K.W., Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998, 282:1497-1501.
33. Lu S., Liu M., Epner D.E., Tsai S.Y., Tsai M.J. Androgen regulation of the cyclin-dependent kinase inhibitor p21 gene through an androgen response element in the proximal promoter. Mol. Endocrinol. 1999, 13:376-384.
34. Corcoran C.A., Montalbano J., Sun H., He Q., Huang Y., Sheikh M.S. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. J. Biol. Chem. 2009, 284:21955-21970.