Identification and Characterization of a Stage Specific Membrane Protein Involved in Flagellar Attachment in Trypanosoma brucei

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Woods, Katherine ^a,c   Nic a'Bhaird, Noirin ^a   Dooley, Clodagh ^a   Perez Morga, David ^b   Nolan, Derek P ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c AUSTIN HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN FLA3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AXONEME; CYTOKINESIS; FLAGELLUM; LIFE CYCLE STAGE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TRYPANOSOMA BRUCEI;

ANIMALS; CELL LINE; FLAGELLA; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MEMBRANE PROTEINS; PROTEIN TRANSPORT; PROTOZOAN PROTEINS; RATS; RNA INTERFERENCE; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA BRUCEI;

EID: 84872381893     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052846     Document Type: Article

References (40)

1. Vickerman K, (1969) On the surface coat and flagellar adhesion in trypanosomes. J Cell Sci 5: 163-193.
2. Sherwin T, Gull K, (1989) The cell division cycle of Trypanosoma brucei brucei: timing of event markers and cytoskeletal modulations. Philos Trans R Soc Lond B Biol Sci 323: 573-588.
3. Kohl L, Gull K, (1998) Molecular architecture of the trypanosome cytoskeleton. Mol Biochem Parasitol 93: 1-9.
4. Bastin P, Pullen TJ, Moreira-Leite FF, Gull K, (2000) Inside and outside of the trypanosome flagellum:a multifunctional organelle. Microbes Infect 2: 1865-1874.
5. Kohl L, Robinson D, Bastin P, (2003) Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes. EMBO J 22: 5336-5346.
6. Kohl L, Bastin P, (2005) The flagellum of trypanosomes. Int Rev Cytol 244: 227-285.
7. Broadhead R, Dawe HR, Farr H, Griffiths S, Hart SR, et al. (2006) Flagellar motility is required for the viability of the bloodstream trypanosome. Nature 440: 224-227.
8. Ralston KS, Hill KL, (2008) The flagellum of Trypanosoma brucei: new tricks from an old dog. Int J Parasitol 38: 869-884.
9. Vaughan S, (2010) Assembly of the flagellum and its role in cell morphogenesis in Trypanosoma brucei. Curr Opin Microbiol 13: 453-458.
10. Oberholzer M, Lopez MA, McLelland BT, Hill KL, (2010) Social motility in african trypanosomes. PLoS Pathog 6: e1000739.
11. Hill KL, (2010) Parasites in motion: flagellum-driven cell motility in African trypanosomes. Curr Opin Microbiol 13: 459-465.
12. Brooks AS, (1978) Ultrastructure of the flagellar attachment site in three species of trypanosomatids. Trans Am Microsc Soc 97: 287-296.
13. Lacomble S, Vaughan S, Gadelha C, Morphew MK, Shaw MK, et al. (2009) Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography. J Cell Sci 122: 1081-1090.
14. Ruiz-Moreno L, Bijovsky AT, Pudles J, Alves MJ, Colli W, (1995) Trypanosoma cruzi: monoclonal antibody to cytoskeleton recognizes giant proteins of the flagellar attachment zone. Exp Parasitol 80: 605-615.
15. Woods A, Sherwin T, Sasse R, MacRae TH, Baines AJ, et al. (1989) Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies. J Cell Sci 93 (Pt 3): 491-500.
16. Woods A, Baines AJ, Gull K, (1989) Evidence for a Mr 88,000 glycoprotein with a transmembrane association to a unique flagellum attachment region in Trypanosoma brucei. J Cell Sci 93 (Pt 3): 501-508.
17. Woodward R, Carden MJ, Gull K, (1995) Immunological characterization of cytoskeletal proteins associated with the basal body, axoneme and flagellum attachment zone of Trypanosoma brucei. Parasitology 111 (Pt 1): 77-85.
18. Kohl L, Sherwin T, Gull K, (1999) Assembly of the paraflagellar rod and the flagellum attachment zone complex during the Trypanosoma brucei cell cycle. J Eukaryot Microbiol 46: 105-109.
19. Vaughan S, Kohl L, Ngai I, Wheeler RJ, Gull K, (2008) A repetitive protein essential for the flagellum attachment zone filament structure and function in Trypanosoma brucei. Protist 159: 127-136.
20. Zhou Q, Liu B, Sun Y, He CY, (2011) A coiled-coil- and C2-domain-containing protein is required for FAZ assembly and cell morphology in Trypanosoma brucei. J Cell Sci 124: 3848-3858.
21. Nozaki T, Haynes PA, Cross GA, (1996) Characterization of the Trypanosoma brucei homologue of a Trypanosoma cruzi flagellum-adhesion glycoprotein. Mol Biochem Parasitol 82: 245-255.
22. LaCount DJ, Barrett B, Donelson JE, (2002) Trypanosoma brucei FLA1 is required for flagellum attachment and cytokinesis. J Biol Chem 277: 17580-17588.
23. Oberholzer M, Langousis G, Nguyen HT, Saada EA, Shimogawa MM, et al. (2011) Independent analysis of the flagellum surface and matrix proteomes provides insight into flagellum signaling in mammalian-infectious Trypanosoma brucei. Mol Cell Proteomics 10: M111 010538.
24. Rubotham J, Woods K, Garcia-Salcedo JA, Pays E, Nolan DP, (2005) Characterization of two protein disulfide isomerases from the endocytic pathway of bloodstream forms of Trypanosoma brucei. J Biol Chem 280: 10410-10418.
25. Nolan DP, Geuskens M, Pays E, (1999) N-linked glycans containing linear poly-N-acetyllactosamine as sorting signals in endocytosis in Trypanosoma brucei. Curr Biol 9: 1169-1172.
26. von Heijne G, (1992) Membrane protein structure prediction hydrophobicity analysis and the positive-inside rule. J Mol Biol 225: 487-494.
27. Carrington M, Carnall N, Crow MS, Gaud A, Redpath MB, et al. (1998) The properties and function of the glycosylphosphatidylinositol-phospholipase C in Trypanosoma brucei. Mol Biochem Parasitol 91: 153-164.
28. Moreira-Leite FF, Sherwin T, Kohl L, Gull K, (2001) A trypanosome structure involved in transmitting cytoplasmic information during cell division. Science 294: 610-612.
29. Briggs LJ, McKean PG, Baines A, Moreira-Leite F, Davidge J, et al. (2004) The flagella connector of Trypanosoma brucei: an unusual mobile transmembrane junction. J Cell Sci 117: 1641-1651.
30. Ralston KS, Hill KL, (2006) Trypanin, a component of flagellar dynein regulatory complex is essential in bloodstream form African trypanosomes. PLoS Pathog 2: e101.
31. Turnock DC, Izquierdo L, Ferguson MA, (2007) The de novo synthesis of GDP-fucose is essential for flagellar adhesion and cell growth in Trypanosoma brucei. J Biol Chem 282: 28853-28863.
32. Muramatsu T, Muramatsu H, (2004) Carbohydrate antigens expressed on stem cells and early embryonic cells. Glycoconj J 21: 41-45.
33. Taylor ME, Drickamer K, (2007) Paradigms for glycan-binding receptors in cell adhesion. Curr Opin Cell Biol 19: 572-577.
34. Graham SA, Antonopoulos A, Hitchen PG, Haslam SM, Dell A, et al. (2011) Identification of neutrophil granule glycoproteins as Lewis(x)-containing ligands cleared by the scavenger receptor C-type lectin. J Biol Chem 286: 24336-24349.
35. Merkle RK, Cummings RD, (1987) Relationship of the terminal sequences to the length of poly-N-acetyllactosamine chains in asparagine-linked oligosaccharides from the mouse lymphoma cell line BW5147. Immobilized tomato lectin interacts with high affinity with glycopeptides containing long poly-N-acetyllactosamine chains. J Biol Chem 262: 8179-8189.
36. Voorheis HP, Gale JS, Owen MJ, Edwards W, (1979) The isolation and partial characterization of the plasma membrane from Trypanosoma brucei. Biochem J 180: 11-24.
37. Hirumi H, Hirumi K, (1994) Axenic culture of African trypanosome bloodstream forms. Parasitol Today 10: 80-84.
38. Brun R, (1979) Schonenberger (1979) Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication. Acta Trop 36: 289-292.
39. Garcia-Salcedo JA, Perez-Morga D, Gijon P, Dilbeck V, Pays E, et al. (2004) A differential role for actin during the life cycle of Trypanosoma brucei. EMBO J 23: 780-789.
40. Spitznagel D, Ebikeme C, Biran M, Nic a' Bhaird N, Bringaud F, et al. (2009) Alanine aminotransferase of Trypanosoma brucei-a key role in proline metabolism in procyclic life forms. FEBS J 276: 7187-7199.