Detection of new biallelic polymorphisms in the human MxA gene

Molecular Biology Reports

Volumn 39, Issue 8, 2012, Pages 8533-8538

  Duc, Tam Tran Thi ^a   Farnir, Frédéric ^a   Michaux, Charles ^a   Desmecht, Daniel ^a   Cornet, Anne ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Innate immunity; Interferon; Mx; Virus

Indexed keywords

GENOMIC DNA; MYXOVIRUS RESISTANCE PROTEIN A;

AFRICAN; ALLELE; AMINO TERMINAL SEQUENCE; ARTICLE; ASIAN; CONTROLLED STUDY; EUROPEAN; EXON; GENE EXPRESSION; GENE FREQUENCY; GENE IDENTIFICATION; GENE LOCATION; GENETIC VARIABILITY; HUMAN; MXA GENE; PROMOTER REGION; RACE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ACTIVITY RELATION;

ALLELES; BASE SEQUENCE; EXONS; GTP-BINDING PROTEINS; HUMANS; MYXOVIRUS RESISTANCE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC;

EID: 84872346020     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1708-7     Document Type: Article

References (20)

1. Haller O, Staeheli P, Kochs G (2009) Protective role of interferon-induced Mx GTPases against influenza viruses. Rev Sci Tech 28:219-231
2. Haller O, Gao S, von der Malsburg A, Daumke O, Kochs G (2010) Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity. J Biol Chem 285:28419-28424
3. Lee SH, Vidal SM (2002) Functional diversity of the Mx proteins: variations on a theme of host resistance to infection. Genome Res 12:527-530
4. Haller O, Kochs G (2011) Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity. J Interferon Cytokine Res 31:79-87
5. Aebi M, Fah J, Hurt N, Samuel CE, Thomis D, Bazzighe L, Pavlovic J, Haller O, Staeheli P (1989) cDNA structures and regulation of two interferon-induced human Mx proteins. Mol Cell Biol 9:5062-5072
6. Tazi-Ahnini R, di Giovine FS, McDonagh AJ, Messenger AG, Amadou C, Cox A, Duff GW, Cork MJ (2000) Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region. Hum Genet 106:639-645
7. Ronni T, Matikainen S, Lehtonen A, Palvimo J, Dellis J, Van Eylen F, Goetschy JF, Horisberger M, Content J, Julkunen I (1998) The proximal interferon-stimulated response elements are essential for interferon responsiveness: a promoter analysis of the antiviral MxA gene. J Interferon Cytokine Res 18:773-781
8. Hijikata M, Ohta Y, Mishiro S (2000) Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon. Intervirology 43:124-127
9. Suzuki F, Arase Y, Suzuki Y, Tsubota A, Akuta N, Hosaka T, Someya T, Kobayashi M, Saitoh S, Ikeda K, Kobayashi M, Matsuda M, Takagi K, Satoh J, Kumada H (2004) Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection. J Viral Hepat 11:271-276
10. Kong XF, Zhang XX, Gong QM, Gao J, Zhang SY, Wang L, Xu J, Han Y, Jin GD, Jiang JH, Zhang DH, Lu ZM (2007) MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment. J Interferon Cytokine Res 27:809-818
11. Knapp S, Yee LJ, Frodsham AJ, Hennig BJ, Hellier S, Zhang L, Wright M, Chiaramonte M, Graves M, Thomas HC, Hill AV, Thursz MR (2003) Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR. Genes Immun 4:411-419
12. Torisu H, Kusuhara K, Kira R, Bassuny WM, Sakai Y, Sanefuji M, Takemoto M, Hara T (2004) Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis. Neurology 62:457-460
13. Hamano E, Hijikata M, Itoyama S, Quy T, Phi NC, Long HT, Ha LD, Ban VV, Matsushita I, Yanai H, Kirikae F, Kirikae T, Kuratsuji T, Sasazuki T, Keicho N (2005) Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population. Biochem Biophys Res Commun 329:1234-1239
14. Furuyama H, Chiba S, Okabayashi T, Yokota S, Nonaka M, Imai T, Fujii N, Matsumoto H (2006) Single nucleotide polymorphisms and functional analysis of MxA promoter region in multiple sclerosis. J Neurol Sci 249:153-157
15. Peng XM, Lei RX, Gu L, Ma HH, Xie QF, Gao ZL (2007) Influences of MxA gene -88 G/T and IFN-gamma +874 A/T on the natural history of hepatitis B virus infection in an endemic area. Int J Immunogenet 34:341-346
16. Cao B, Liu X, Hou F, Li W, Han Z, Zhang Q, Dai Y, Xu C, Qi H (2009) The haplotype of the MxA gene promoter is associated with hepatitis B virus infection in a Chinese population. Liver Int 29:1383-1388
17. Ching JC, Chan KY, Lee EH, Xu MS, Ting CK, So TM, Sham PC, Leung GM, Peiris JS, Khoo US (2010) Significance of the myxovirus resistance A (MxA) gene -123C> a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection. J Infect Dis 201:1899-1908
18. Gao S, von der Malsburg A, Dick A, Faelber K, Schröder GF, Haller O, Kochs G, Daumke O (2011) Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function. Immunit 35:514-525
19. Henikoff S, Henikoff JG (1992) Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci USA 89:10915-10919
20. He J, Feng D, de Vlas SJ, Wang H, Fontanet A, Zhang P, Plancoulaine S, Tang F, Zhan L, Yang H, Wang T, Richardus JH, Habbema JD, Cao W (2006) Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study. BMC Infect Dis. doi: 10.1186/1471-2334-6-106