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Volumn 7, Issue , 2013, Pages 13-17

New treatments for myasthenia: A focus on antisense oligonucleotides

Author keywords

Acetyl cholinesterase; Antisense oligonucleotides; EN101; Myasthenia gravis

Indexed keywords

ACETYLCHOLINESTERASE; ANTISENSE OLIGONUCLEOTIDE; CHOLINESTERASE INHIBITOR; DYFLOS; EN 101; IMMUNOMODULATING AGENT; MONARSEN; PYRIDOSTIGMINE; STEROID; UNCLASSIFIED DRUG;

EID: 84872343234     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S25716     Document Type: Article
Times cited : (21)

References (25)
  • 1
    • 0028779203 scopus 로고
    • Myasthenia gravis
    • Drachman DB. Myasthenia gravis. N Engl J Med. 1994;330(25): 1797-1810.
    • (1994) N Engl J Med. , vol.330 , Issue.25 , pp. 1797-1810
    • Drachman, D.B.1
  • 2
    • 0035105784 scopus 로고    scopus 로고
    • Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptors antibodies
    • Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A, Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptors antibodies. Net Med. 2001;7(3):365-368.
    • (2001) Net Med , vol.7 , Issue.3 , pp. 365-368
    • Hoch, W.1    McConville, J.2    Helms, S.3    Newsom-Davis, J.4    Melms, A.5    Vincent, A.6
  • 3
    • 33645330973 scopus 로고    scopus 로고
    • Molecular architecture of the neuromuscular junction
    • Hughes B W, Kusner LL, Kaminski HJ. Molecular architecture of the neuromuscular junction. Muscle Nerve. 2006;33(4):445-461.
    • (2006) Muscle Nerve , vol.33 , Issue.4 , pp. 445-461
    • Hughes, B.W.1    Kusner, L.L.2    Kaminski, H.J.3
  • 4
    • 77951692983 scopus 로고    scopus 로고
    • editor, St Paul, MN: Myastehia Gravis Foundation of America, Accessed November 18, 2008
    • Howard JF Jr, editor. Myasthenia Gravis: A Manual for the Health Care Provider. St Paul, MN: Myastehia Gravis Foundation of America; 2008. Available from: http://www.myasthenia.org/LinkClick.aspx?fleticket=S472fPAE1ow%3D&tabid=69. Accessed November 18, 2008.
    • (2008) Myasthenia Gravis: A Manual For the Health Care Provider
    • Howard Jr., J.F.1
  • 5
    • 3142755799 scopus 로고    scopus 로고
    • Combinatorial complexity of 5 alternative acetylcholinesterase transcripts and protein products
    • Meshorer E, Toiber D, Zurel D, et al. Combinatorial complexity of 5 alternative acetylcholinesterase transcripts and protein products. J Biol Chem. 2004;279:29740-29751.
    • (2004) J Biol Chem , vol.279 , pp. 29740-29751
    • Meshorer, E.1    Toiber, D.2    Zurel, D.3
  • 6
    • 27544499653 scopus 로고    scopus 로고
    • SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA
    • Meshorer E, Bryk B, Toiber D, et al. SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA. Mol Psychiatry. 2005;10:985-997.
    • (2005) Mol Psychiatry , vol.10 , pp. 985-997
    • Meshorer, E.1    Bryk, B.2    Toiber, D.3
  • 7
    • 33645988822 scopus 로고    scopus 로고
    • Virtues and woes of AChE alternative splicing in stress-related neuropathologies
    • Meshorer E, Soreq H. Virtues and woes of AChE alternative splicing in stress-related neuropathologies. Trends Neurosci. 2006;29(4): 216-224.
    • (2006) Trends Neurosci , vol.29 , Issue.4 , pp. 216-224
    • Meshorer, E.1    Soreq, H.2
  • 8
    • 0036560908 scopus 로고    scopus 로고
    • The origin of the molecular diversity and functional anchoring of cholinesterases
    • Massoulié J. The origin of the molecular diversity and functional anchoring of cholinesterases. Neurosignals. 2002;11:130-143.
    • (2002) Neurosignals , vol.11 , pp. 130-143
    • Massoulié, J.1
  • 9
    • 0026335386 scopus 로고
    • Gene structure of mammalian acetylcholinesterase. Alternative exons dictate tissue-specifc expression
    • Li Y, Camp S, Rachinsky TL, Getman D, Taylor P. Gene structure of mammalian acetylcholinesterase. Alternative exons dictate tissue-specifc expression. J Biol Chem. 1991;266:23083-23090.
    • (1991) J Biol Chem , vol.266 , pp. 23083-23090
    • Li, Y.1    Camp, S.2    Rachinsky, T.L.3    Getman, D.4    Taylor, P.5
  • 10
    • 0029004391 scopus 로고
    • Synaptic and epidermal accumulations of human acetylcholinesterase are encoded by alternative 3′-terminal exons
    • Seidman S, Sternfeld M, Ben Aziz-Aloya R, Timberg R, Kaufer-Nachum D, Soreq H. Synaptic and epidermal accumulations of human acetylcholinesterase are encoded by alternative 3′-terminal exons. Mol Cell Biol. 1995;15:2993-3002.
    • (1995) Mol Cell Biol , vol.15 , pp. 2993-3002
    • Seidman, S.1    Sternfeld, M.2    Ben Aziz-Aloya, R.3    Timberg, R.4    Kaufer-Nachum, D.5    Soreq, H.6
  • 11
    • 0033402485 scopus 로고    scopus 로고
    • Tracking cholinergic pathways from psychological and chemical stressors to variable neurodeterioration paradigms
    • Kaufer D, Soreq H. Tracking cholinergic pathways from psychological and chemical stressors to variable neurodeterioration paradigms. Curr Opin Neurol. 1999;12:739-743.
    • (1999) Curr Opin Neurol , vol.12 , pp. 739-743
    • Kaufer, D.1    Soreq, H.2
  • 12
    • 0037308205 scopus 로고    scopus 로고
    • The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis
    • Brenner T, Hamra-Amitay Y, Evron T, Boneva N, Seidman S, Soreq H. The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis. FASEB J. 2003;17:214-222.
    • (2003) FASEB J , vol.17 , pp. 214-222
    • Brenner, T.1    Hamra-Amitay, Y.2    Evron, T.3    Boneva, N.4    Seidman, S.5    Soreq, H.6
  • 13
    • 0034041136 scopus 로고    scopus 로고
    • Synaptogenesis and myopathy under acetylcholinesterase overexpression
    • Lev-Lehman E, Evron T, Broide RS, et al. Synaptogenesis and myopathy under acetylcholinesterase overexpression. J Mol Neurosci. 2000;14:93-105.
    • (2000) J Mol Neurosci , vol.14 , pp. 93-105
    • Lev-Lehman, E.1    Evron, T.2    Broide, R.S.3
  • 14
    • 0029021009 scopus 로고
    • Successive organophosphate inhibition and oxime reactivation reveals distinct responses of recombinant human cholinesterase variants
    • Schwarz M, Loewenstein-Lichtenstein Y, Glick D, Liao J, Norgaard-Pedersen B, Soreq H. Successive organophosphate inhibition and oxime reactivation reveals distinct responses of recombinant human cholinesterase variants. Brain Res Mol Brain Res. 1995;31:101-110.
    • (1995) Brain Res Mol Brain Res , vol.31 , pp. 101-110
    • Schwarz, M.1    Loewenstein-Lichtenstein, Y.2    Glick, D.3    Liao, J.4    Norgaard-Pedersen, B.5    Soreq, H.6
  • 15
    • 0032574973 scopus 로고    scopus 로고
    • Acute stress facilitates long-lasting changes in cholinergic gene expression
    • Kaufer D, Friedman A, Seidman S, Soreq H. Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature. 1998;393: 373-377.
    • (1998) Nature , vol.393 , pp. 373-377
    • Kaufer, D.1    Friedman, A.2    Seidman, S.3    Soreq, H.4
  • 17
    • 33845673318 scopus 로고    scopus 로고
    • Neuromuscular therapeutics by RNA-targeted suppression of ACHE gene expression
    • Dori A, Soreq H. Neuromuscular therapeutics by RNA-targeted suppression of ACHE gene expression. Ann N Y Acad Sci. 2006;1082: 77-90.
    • (2006) Ann N Y Acad Sci , vol.1082 , pp. 77-90
    • Dori, A.1    Soreq, H.2
  • 18
    • 0035320772 scopus 로고    scopus 로고
    • Acetylcholinesterase - new roles for an old actor
    • Soreq H, Seidman S. Acetylcholinesterase - new roles for an old actor. Nat Rev Neurosci. 2001;2:294-302.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 294-302
    • Soreq, H.1    Seidman, S.2
  • 19
    • 0025596995 scopus 로고
    • Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure
    • Soreq H, Ben-Aziz R, Prody CA, et al. Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure. Proc Natl Acad Sci U S A. 1990;87: 9688-9692.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 9688-9692
    • Soreq, H.1    Ben-Aziz, R.2    Prody, C.A.3
  • 20
    • 23844441866 scopus 로고    scopus 로고
    • RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons
    • Evron T, Moyal-Segal LB, Lamm N, Geffen A, Soreq H. RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons. Neurodegener Dis. 2005;2(1):16-27.
    • (2005) Neurodegener Dis , vol.2 , Issue.1 , pp. 16-27
    • Evron, T.1    Moyal-Segal, L.B.2    Lamm, N.3    Geffen, A.4    Soreq, H.5
  • 21
    • 18244401355 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production
    • Pollak Y, Gilboa A, Ben-Menachem O, Ben-Hur T, Soreq H, Yirmiya R. Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production. Ann Neurol. 2005;57(5):741-745.
    • (2005) Ann Neurol , vol.57 , Issue.5 , pp. 741-745
    • Pollak, Y.1    Gilboa, A.2    Ben-Menachem, O.3    Ben-Hur, T.4    Soreq, H.5    Yirmiya, R.6
  • 22
    • 84872321707 scopus 로고    scopus 로고
    • RNA therapy results announced to attract suitors [opinion]
    • Amarin
    • Amarin: RNA therapy results announced to attract suitors [opinion]. PharmaWatch: Monthly Review. 2009;8(7):27-28.
    • (2009) PharmaWatch: Monthly Review , vol.8 , Issue.7 , pp. 27-28
  • 23
    • 0034713266 scopus 로고    scopus 로고
    • Vagus nerve stimulation attenuates the systemic infammatory response to endotoxin
    • Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic infammatory response to endotoxin. Nature. 2000;405:458-462.
    • (2000) Nature , vol.405 , pp. 458-462
    • Borovikova, L.V.1    Ivanova, S.2    Zhang, M.3
  • 24
    • 0034746345 scopus 로고    scopus 로고
    • Disruption of the IL-1beta gene diminishes acetylcholine receptor-induced immune responses in a murine model of myasthenia gravis
    • Huang D, Shi FD, Giscombe R, Zhou Y, Ljunggren HG, Lefvert AK. Disruption of the IL-1beta gene diminishes acetylcholine receptor-induced immune responses in a murine model of myasthenia gravis. Eur J Immunol. 2001;31:225-232.
    • (2001) Eur J Immunol , vol.31 , pp. 225-232
    • Huang, D.1    Shi, F.D.2    Giscombe, R.3    Zhou, Y.4    Ljunggren, H.G.5    Lefvert, A.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.