Neuro-oncology: Understanding the molecular complexity of medulloblastoma

Nature Reviews Neurology

Volumn 8, Issue 10, 2012, Pages 539-540

  Packer, Roger J ^a   Hoffman, Eric P ^b  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRG1 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 4; HISTONE DEACETYLASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; SOMATOMEDIN C RECEPTOR;

ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CARCINOGENESIS; CDKG GENE; COPY NUMBER VARIATION; CTDNEP1 GENE; CTNNB1 GENE; DDX3X GENE; DRUG EFFICACY; DRUG TARGETING; ERBB4 GENE; GENE; GENE AMPLIFICATION; GENE EXPRESSION; GENE FUSION; GENE MUTATION; GENOMIC INSTABILITY; GLIOBLASTOMA; HDAC2 GENE; HISTONE MODIFICATION; HUMAN; IGF1R GENE; KIT GENE; MALIGNANT TRANSFORMATION; MEDULLOBLASTOMA; MLL2 GENE; MLL3 GENE; MOLECULAR PATHOLOGY; MOLECULARLY TARGETED THERAPY; MYCN GENE; ONCOGENE MYC; OTX2 GENE; PDGFRA GENE; PI3K GENE; PRIORITY JOURNAL; PTEN GENE; RNA SEQUENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SMARCA4 GENE; SNCAIP GENE; SOMATIC MUTATION;

BRAIN NEOPLASMS; HUMANS; MEDICAL ONCOLOGY; MEDULLOBLASTOMA; MOLECULAR DYNAMICS SIMULATION; MUTATION; TUMOR MARKERS, BIOLOGICAL;

EID: 84872338900     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2012.197     Document Type: Article

References (9)

1. Packer, R. J. et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J. Clin. Oncol. 24, 4202-4208 (2006). (Pubitemid 46622300)
2. Ris, M. D., Packer, R., Goldwein, J., Jones-Wallace, D. & Boyett, J. M. Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study. J. Clin. Oncol. 19, 3470-3476 (2001). (Pubitemid 32730083)
3. Armstrong, G. T. et al. Region-specific radiotherapy and neuropsychological outcomes in adult survivors of childhood CNS malignancies. Neuro Oncol. 12, 1173-1186 (2010).
4. Taylor, M. D. et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 123, 465-472 (2012).
5. Kool, M. K. et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 123, 473-484 (2012).
6. Pugh, T. J. et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 488, 106-110 (2012).
7. Parsons, D. W. et al. The genetic landscape of the childhood cancer medulloblastoma. Science 331, 435-439 (2011).
8. Jones, D. T. et al. Dissecting the genomic complexity underlying medulloblastoma. Nature 488, 100-105 (2012).
9. Northcott, P. A. et al. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature 488, 49-56 (2012).