High HIV-1 incidence, correlates of HIV-1 acquisition, and high viral loads following seroconversion among MSM

AIDS

Volumn 27, Issue 3, 2013, Pages 437-446

  Sanders, Eduard J ^a,b   Okuku, Haile S ^a   Smith, Adrian D ^c   Mwangome, Mary ^a   Wahome, Elizabeth ^a   Fegan, Gregory ^a,b   Peshu, Norbert ^a   Van Der Elst, Elisabeth M ^a   Price, Matthew A ^d   McClelland, R Scott ^e,f   Graham, Susan M ^a,e,f  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

^e UNIVERSITY OF NAIROBI   (Kenya)

^f UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Africa; anal intercourse; gonorrhoea; group sex; HIV 1 incidence; MSM; sexually transmitted infection; viral load

Indexed keywords

VIRUS RNA;

ADULT; ANUS INTERCOURSE; ARTICLE; FEMALE; GONORRHEA; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; INCIDENCE; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; MALE HOMOSEXUAL; MEN WHO REPORTED SEX WITH MEN AND WOMEN; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEROCONVERSION; SEXUAL BEHAVIOR; SYPHILIS; VIRUS LOAD;

ADOLESCENT; ADULT; CONDOMS; COUNSELING; GONORRHEA; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HERPES GENITALIS; HIV SEROPOSITIVITY; HIV-1; HOMOSEXUALITY, MALE; HUMANS; INCIDENCE; KENYA; MALE; NEEDS ASSESSMENT; PROSPECTIVE STUDIES; RISK FACTORS; SEXUAL BEHAVIOR; SOCIAL STIGMA; VIRAL LOAD;

EID: 84872326798     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32835b0f81     Document Type: Article

References (35)

1. Sanders EJ, Wahome E, Mwangome M, Thiong'o AN, Okuku HS, Price MA, et al. Most adults seek urgent healthcare when acquiring HIV-1 and are frequently treated for malaria in Coastal Kenya. AIDS 2011; 25:1219-1224.
2. Smith AD, Tapsoba P, Peshu N, Sanders EJ, Jaffe HW. Men who have sex with men and HIV/AIDS in sub-Saharan Africa. Lancet 2009; 374:416-422.
3. Baral S, Sifakis F, Cleghorn F, Beyrer C. Elevated risk for HIV infection among men who have sex with men in low-and middle-income countries 2000-2006: a systematic review. PLoS Med 2007; 4:e339.
4. Caceres CF, Konda K, Segura ER, Lyerla R. Epidemiology of male same-sex behaviour and associated sexual health indicators in low-and middle-income countries: 2003-2007 estimates. Sex Transm Infect 2008; 84 (Suppl 1):i49-i56.
5. Beyrer C, Baral SD, Walker D, Wirtz AL, Johns B, Sifakis F. The expanding epidemics of HIV type 1 among men who have sex with men in low-and middle-income countries: diversity and consistency. Epidemiol Rev 2010; 32:137-151.
6. Beyrer C, Baral SD, van Griensven F, Goodreau SM, Chariya-lertsak S, Wirtz AL, et al. Global epidemiology of HIV infection in men who have sex with men. Lancet 2012; 380:367-377.
7. Braunstein SL, van de Wijgert JH, Nash D. HIV incidence in sub-Saharan Africa: a review of available data with implications for surveillance and prevention planning. AIDS Rev 2009; 11:140-156.
8. Price M, Rida W, Mwangome M, Mutua G, Middelkoop K, Roux S, et al. Identifying at-risk populations in Kenya and South Africa: HIV incidence in cohorts of men who report sex with men, sex workers, and youth. J Acquir Immune Defic Syndr 2012; 59:185-193.
9. Sanders EJ, Graham SM, Okuku HS, van der Elst EM, Muhaari A, Davies A, et al. HIV-1 infection in high risk men who have sex with men in Mombasa, Kenya. AIDS 2007; 21:2513-2520.
10. Geibel S, van der Elst EM, King'ola N, Luchters S, Davies A, Getambu EM, et al. 'Are you on the market?': a capture-recapture enumeration of men who sell sex to men in and around Mombasa, Kenya. AIDS 2007; 21:1349-1354.
11. Tindana PO, Singh JA, Tracy CS, Upshur RE, Daar AS, Singer PA, et al. Grand challenges in global health: community engagement in research in developing countries. PLoS Med 2007; 4:e273.
12. Grijsen ML, Graham SM, Mwangome M, Githua P, Mutimba S, Wamuyu L, et al. Screening for genital and anorectal sexually transmitted infections in HIV prevention trials in Africa. Sex Transm Infect 2008; 84:364-370.
13. van der Elst EM, Okuku HS, Nakamya P, Muhaari A, Davies A, McClelland RS, et al. Is audio computer-assisted self-interview (ACASI) useful in risk behaviour assessment of female and male sex workers, Mombasa, Kenya? PLoS One 2009; 4:e5340.
14. Duncan S, Thiong'o AN, Macharia M, Wamuyu L, Mwarumba S, Mvera B, et al. High prevalence of quinolone resistance in Neisseria gonorrhoeae in coastal Kenya. Sex Transm Infect 2011; 87:231.
15. Fiebig EW, Wright DJ, Rawal BD, Garrett PE, Schumacher RT, Peddada L, et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS 2003; 17:1871-1879.
16. Jansen IA, Geskus RB, Davidovich U, Jurriaans S, Coutinho RA, Prins M, et al. Ongoing HIV-1 transmission among men who have sex with men in Amsterdam: a 25-year prospective cohort study. AIDS 2011; 25:493-501.
17. Okuku HS, Sanders EJ, Nyiro J, Ngetsa C, Ohuma E, McClelland RS, et al. Factors associated with herpes simplex virus type 2 incidenceina cohortofhuman immunodeficiency virustype 1-seronegative Kenyan men and women reporting high-risk sexual behavior. Sex Transm Dis 2011; 38:837-844.
18. Brown EL, Wald A, Hughes JP, Morrow RA, Krantz E, Mayer K, et al. High risk of human immunodeficiency virus in men who have sex with men with herpes simplex virus type 2 in the EXPLORE study. Am J Epidemiol 2006; 164:733-741.
19. McClelland RS, Graham SM, Richardson BA, Peshu N, Masese LN, Wanje GH, et al. Treatment with antiretroviral therapy is not associated with increased sexual risk behavior in Kenyan female sex workers. AIDS 2010; 24:891-897.
20. Smith AD, Ferguson A, Kowuar D, van der Elst E, Agwanda C, Muhaari A, et al. Role versatility and female partnerships among MSM sex workers in Mombasa, Kenya. Paper presented at the 16th Conference on Retroviruses and Opportunistic Infections; Montreal, Canada; 2009.
21. Tovanabutra S, Sanders EJ, Graham SM, Mwangome M, Peshu N, McClelland RS, et al. Evaluation of HIV type 1 strains in men having sex with men and in female sex workers in Mombasa, Kenya. AIDS Res Hum Retroviruses 2010; 26:123-131.
22. Powers KA, Ghani AC, Miller WC, Hoffman IF, Pettifor AE, Kamanga G, et al. The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling study. Lancet 2011; 378:256-268.
23. Sullivan P, Carballo-Dieguez A, Coates T, Goodreau S, McGowan I, Sanders EJ, et al. Successes and challenges of HIV prevention in men who have sex with men. Lancet 2012; 380:388-399.
24. Comparison of female to male and male to female transmission of HIV in 563 stable couples. European Study Group on Heterosexual Transmission of HIV. BMJ 1992; 304: 809-813.
25. Varghese B, Maher JE, Peterman TA, Branson BM, Steketee RW. Reducing the risk of sexual HIV transmission: quantifying the per-act risk for HIV on the basis of choice of partner, sex act, and condom use. Sex Transm Dis 2002; 29:38-43.
26. Coates TJ, Richter L, Caceres C. Behavioural strategies to reduce HIV transmission: how to make them work better. Lancet 2008; 372:669-684.
27. Johnson WD, Hedges LV, Ramirez G, Semaan S, Norman LR, Sogolow E, et al. HIV prevention research for men who have sex with men: a systematic review and meta-analysis. J Acquir Immune Defic Syndr 2002; 30 (Suppl 1):S118-S129.
28. Dietrich J, Khunwane M, Laher F, de Bruyn G, Sikkema KJ, Gray G. 'Group sex' parties and other risk patterns: a qualitative study about the perceptions of sexual behaviors and attitudes of adolescents in Soweto, South Africa. Vulnerable Child Youth Stud 2011; 11:244-254.
29. Johnston LG, Holman A, Dahoma M, Miller LA, Kim E, Mussa M, et al. HIV risk and the overlap of injecting drug use and high-risk sexual behaviours among men who have sex with men in Zanzibar (Unguja), Tanzania. Int J Drug Policy 2010; 21:485-492.
30. Sanders EJ, Thiong'o AN, Okuku HS, Mwambi J, Priddy F, Shafi J, et al. High prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infections among HIV-1 negative men who have sex with men in coastal Kenya. Sex Transm Infect 2010; 86:440-441.
31. Bernstein KT, Marcus JL, Nieri G, Philip SS, Klausner JD. Rectal gonorrhea and chlamydia reinfection is associated with increased risk of HIV seroconversion. J Acquir Immune Defic Syndr 2010; 53:537-543.
32. WHO. Prevention and treatment of HIV and other sexually transmitted infections among men who have sex with men and transgender people. Switzerland: World Health Organization; 2011 pp. 1-86.
33. Okuku HS, Wahome E, Duncan S, Thiongo' A, Mwambi J, Shafi J, et al. Evaluation of presumptive treatment recommendation for asymptomatic anorectal gonorrhoea and chlamydia infections in at-risk MSM in Kenya. IAS Conference; Washington DC; 21-26 July 2012.
34. Tobian AA, Ssempijja V, Kigozi G, Oliver AE, Serwadda D, Makumbi F, et al. Incident HIV and herpes simplex virus type 2 infection among men in Rakai, Uganda. AIDS 2009; 23:1589-1594.
35. Lane T, Raymond HF, Dladla S, Rasethe J, Struthers H, McFar-land W, et al. High HIV prevalence among men who have sex with men in Soweto, South Africa: results from the Soweto Men's study. AIDS Behav 2011; 15:626-634.