Peptidoglycan and muramyl dipeptide from Staphylococcus aureus induce the expression of VEGF-A in human limbal fibroblasts with the participation of TLR2-NFκB and NOD2-EGFR

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 251, Issue 1, 2013, Pages 53-62

  Juárez–Verdayes, Marco Adán ^a   Rodríguez–Martínez, Sandra ^a   Cancino–Diaz, Mario E ^a   Cancino Diaz, Juan C ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Limbal fibroblasts; Muramyl dipeptide; NOD2; Peptidoglycan; Staphylococcus aureus; TLR2; VEGF

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOTEICHOIC ACID; MURAMYL DIPEPTIDE; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR 2; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; FLOW CYTOMETRY; GENE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROPHAGE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL LIKE RECEPTOR 2 GENE; VASCULAR ENDOTHELIAL GROWTH FACTOR A GENE; VASCULAR ENDOTHELIAL GROWTH FACTOR B GENE; VASCULAR ENDOTHELIAL GROWTH FACTOR C GENE; VASCULAR ENDOTHELIAL GROWTH FACTOR D GENE;

EID: 84872326213     PISSN: 0721832X     EISSN: 1435702X     Source Type: Journal    
DOI: 10.1007/s00417-012-2130-5     Document Type: Article

References (38)

1. Homer JJ, Prentice MG, Cawkwell L, Birchall M, Greenman J, Stafford ND (2003) Angiogenesis and the expression of vascular endothelial growth factors A and C in squamous cell carcinoma of the Piriform Fossa. Arch Otolaryngol Head Neck Surg 129:1110-1114
2. Ferguson TA, Apte RS (2008) Angiogenesis in eye disease: immunity gained or immunity lost? Semin Immunopathol 30:111-119
3. Nakao S, Hata Y, Miura M, Noda K, Kimura YN, Kawahara S, Kita T, Hisatomi T, Nakazawa T, Jin Y, Dana MR, Kuwano M, Ono M, Ishibashi T, Hafezi-Moghadam A (2007) Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis. Am J Pathol 171:1058-1065
4. Yuuki T, Kanda T, Kishi S (2006) Expression of ephrin in retinal neovascularization and iris rubeosis. J Int Med Res 34:485-494
5. Chen J, Connor KM, Aderman CM, Willett KL, Aspegren OP, Smith LEH (2009) Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci 50:1329-1335
6. Kusari J, Padillo E, Zhou SX, Bai Y, Wang J, Song Z, Zhu M, Le YZ, Gil DW (2011) Effect of brimonidine on retinal and choroidal neovascularization in a mouse model of retinopathy of prematurity and laser-treated rats. Invest Ophthalmol Vis Sci 52:5424-5431
7. Coman L, Coman OA, Pǎunescu H, Drǎghia F, Fulga I (2010) VEGF-induced corneal neovascularisation in a rabbit experimental model. Rom J Morphol Embryol 51:327-336
8. Chien MH, Ku CC, Johansson G, Chen MW, Hsiao H, Su JL, Inoue H, Hua KT, Wei LH, Kuo ML (2009) Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis 30:2005-2013
9. Benest AV, Harper SJ, Herttuala SY, Alitalo K, Bates DO (2008) VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis. Cardiovasc Res 78:315-323
10. Hollborn M, Bringmann A, Faude F, Wiedemann P, Kohen L (2006) Signaling pathways involved in PDGF-evoked cellular responses in human RPE cells. Biochem Biophys Res Commun 344:912-919
11. Nishiguchi KM, Nakamura M, Kaneko H, Kachi S, Terasaki H (2007) The role of VEGF and VEGFR2/Flk1 in proliferation of retinal progenitor cells in murine retinal degeneration. Invest Ophthalmol Vis Sci 48:4315-4320
12. Ambati BK, Nozaki M, Singh N, Takeda A, Jani PD, Suthar T, Albuquerque RJ, Richter E, Sakurai E, Newcomb MT, Kleinman ME, Caldwell RB, Lin Q, Ogura Y, Orecchia A, Samuelson DA, Agnew DW, St Leger J, Green WR, Mahasreshti PJ, Curiel DT, Kwan D, Marsh H, Ikeda S, Leiper LJ, Collinson JM, Bogdanovich S, Khurana TS, Shibuya M, Baldwin ME, Ferrara N, Gerber HP, De Falco S, Witta J, Baffi JZ, Raisler BJ, Ambati J (2006) Corneal avascularity is due to soluble VEGF receptor-1. Nature 443:993-997
13. Cursiefen C, Chen L, Saint-Geniez M, Hamrah P, Jin Y, Rashid S, Pytowski B, Persaud K, Wu Y, Streilein JW, Dana R (2006) Nonvascular VEGFR3-expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci USA 103:11405-11410
14. Sonnex C (2010) Toll-like receptors and genital tract infection. Int J STD AIDS 21:153-157
15. Kiriakidis S, Andreakos E, Monaco C, Foxwell B, Feldmann M, Paleolog E (2003) VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2. J Cell Sci 116:665-674
16. Zheng M, Klinman DM, Gierynska M, Rouse BT (2002) DNA containing CpG motifs induces angiogenesis. Proc Natl Acad Sci USA 99:8944-8949
17. Klinman DM, Zheng M, Gierynska M, Rouse BT (2002) DNA containing bioactive CpG motifs promote angiogenesis. Drug News Perspect 15:358-363
18. Leibovich SJ, Chen JF, Pinhal-Enfield G, Belem PC, Elson G, Rosania A, Ramanathan M, Montesinos C, Jacobson M, Schwarzschild MA, Fink JS, Cronstein B (2002) Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. Am J Pathol 160:2231-2244
19. Rodriguez-Martinez S, Cancino-Diaz ME, Miguel PS, Cancino-Diaz JC (2006) Lipopolysaccharide from Escherichia coli induces the expression of vascular endothelial growth factor via toll-like receptor 4 in human limbal fibroblasts. Exp Eye Res 83:1373-1377
20. Koff JL, Shao MXG, Ueki IF, Nadel JA (2008) Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol 294:L1068-L1075
21. Yuan X, Wilhelmus KR (2009) Corneal neovascularization during experimental fungal keratitis. Mol Vis 15:1988-1996
22. Martin G, Schlunck G, Hansen LL, Agostini HT (2004) Differential expression of angioregulatory factors in normal and CNV-derived human retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol 242:321-326
23. Ikeda Y, Yonemitsu Y, Onimaru M, Nakano T, Miyazaki M, Kohno R, Nakagawa K, Ueno A, Sueishi K, Ishibashi T (2006) The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium. Exp Eye Res 83:1031-1040
24. Simpson DA, Murphy GM, Bhaduri T, Gardiner TA, Archer BD, Stitt AW (1999) Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia. Biochem Biophys Res Commun 262:333-340
25. Cho ML, Ju JH, Kim HR, Oh HJ, Kang CM, Jhun JY, Lee SY, Park MK, Min JK, Park SH, Lee SH, Kim HY (2007) Toll-like receptor 2 ligand mediates the upregulation of angiogenic factor, vascular endothelial growth factor and interleukin-8/CXCL8 in human rheumatoid synovial fibroblasts. Immunol Lett 108:121-128
26. Qiu JG, Factor S, Chang TH, Knighton D, Nadel H, Levenson SM (2000) Wound healing: captopril, an angiogenesis inhibitor, and Staphylococcus aureus peptidoglycan. J Surg Res 92:177-185
27. Huang S, Robinson JB, DeGuzman A, Bucana CD, Fidler IJ (2000) Blockade of Nuclear Factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of Vascular Endothelial Growth Factor and Interleukin 8. Cancer Res 60:5334-5339
28. Li J, Shen J, Beuerman RW (2007) Expression of toll-like receptors in human limbal and conjunctival epithelial cells. Mol Vis 13:813-822
29. Gao T, Lin Z, Jin X (2009) Hydrocortisone suppression of the expression of VEGF may relate to toll-like receptor (TLR) 2 and 4. Curr Eye Res 34:777-784
30. Telles PD, Hanks CT, Machado MA, Nör JE (2003) Lipoteichoic acid up-regulates VEGF expression in macrophages and pulp cells. J Dent Res 82:466-470
31. You L, Kruse FE, Bacher S, Schmitz ML (2002) Lipoteichoic acid selectively induces the ERK signaling pathway in the cornea. Invest Ophthalmol Vis Sci 43:2272-2277
32. Kumar A, Zhang J, Yu FS (2004) Innate immune response of corneal epithelial cells to Staphylococcus aureus infection: role of peptidoglycan in stimulating proinflammatory cytokine secretion. Invest Ophthalmol Vis Sci 45:3513-3522
33. Heyer G, Saba S, Adamo R, Rush W, Soong G, Cheung A, Prince A (2002) Staphylococcus aureus agr and sarA functions are required for invasive infection but not inflammatory responses in the lung. Infect Immun 70:127-133
34. Guan R, Roychowdhury A, Ember B, Kumar S, Boons GJ, Mariuzza RA (2004) Structural basis for peptidoglycan binding by peptidoglycan recognition proteins. Proc Natl Acad Sci USA 101:17168-17173
35. Rodríguez-Martínez S, Cancino-Diaz ME, Jiménez- Zamudio L, García-Latorre E, Cancino-Diaz JC (2005) TLRs and NODs mRNA expression pattern in healthy mouse eye. Br J Ophthalmol 89:904-910
36. Scurrell E, Stanley R, Schöniger S (2009) Immunohistochemical detection of NOD1 and NOD2 in the healthy murine and canine eye. Vet Ophthalmol 12:269-275
37. Renner U, De Santana EC, Gerez J, Fröhlich B, Haedo M, Pereda MP, Onofri C, Stalla GK, Arzt E (2009) Intrapituitary expression and regulation of the gp130 cytokine interleukin-6 and its implication in pituitary physiology and pathophysiology. Ann N Y Acad Sci 1153:89-97
38. Lipinski S, Till A, Sina C, Arlt A, Grasberger H, Schreiber S, Rosenstiel P (2009) DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses. J Cell Sci 122:3522-3530