Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression

Virology Journal

Volumn 10, Issue 1, 2013, Pages

  Xu, Xin Gang ^a   Zhang, Honglei ^a   Zhang, Qi ^a   Dong, Jie ^a   Liang, Yabing ^a   Huang, Yong ^a   Liu, Hung Jen ^b   Tong, De Wen ^a  

^a NORTHWEST A F UNIVERSITY   (China)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Bcl 2; E protein; ER stress; IL 8; NF b; PEDV

Indexed keywords

CYCLIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; PORCINE EPIDEMIC DIARRHEA VIRUS E PROTEIN; PROTEIN BCL 2; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRULENCE FACTOR;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL GROWTH; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; INTESTINE EPITHELIUM CELL; NONHUMAN; PORCINE EPIDEMIC DIARRHEA VIRUS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL NUCLEUS; CHEMISTRY; ENDOPLASMIC RETICULUM; EPITHELIUM CELL; METABOLISM; PATHOGENICITY; SWINE; VIROLOGY;

PORCINE EPIDEMIC DIARRHEA VIRUS; SUIDAE;

ANIMALS; CELL NUCLEUS; CELLS, CULTURED; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL CELLS; INTERLEUKIN-8; NF-KAPPA B; PORCINE EPIDEMIC DIARRHEA VIRUS; SWINE; VIRAL PROTEINS; VIRULENCE FACTORS;

MLCS; MLOWN;

EID: 84872317534     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-10-26     Document Type: Article

References (37)

1. Ducatelle R, Coussement W, Pensaert MB, Debouck P, Hoorens J: In vivo morphogenesis of a new porcine enteric coronavirus, CV 777. Arch Virol 1981, 68:35-44.
2. Pensaert MB, de Bouck P: A new coronavirus-like particle associated with diarrhea in swine. Arch Virol 1978, 58:243-247.
3. Hou X-L, Yu L-Y, Liu J: Development and evaluation of enzyme-linked immunosorbent assay based on recombinant nucleocapsid protein for detection of porcine epidemic diarrhea (PEDV) antibodies. Vet Microbiol 2007, 123:86-92.
4. Song D, Park B: Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines. Virus Genes 2012, 44:167-175.
5. Carvajal A, Lanza I, Diego R, Rubio P, Camenes P: Evaluation of a blocking ELISA using monoclonal antibodies for the detection of porcine epidemic diarrhea virus and its antibodies. J Vet Diagn Invest 1995, 7:60-64.
6. Wang K, Lu W, Chen J, Xie S, Shi H, Hsu H, Yu W, Xu K, Bian C, Fischer WB, et al: PEDV ORF3 encodes an ion channel protein and regulates virus production. FEBS Lett 2012, 586:384-391.
7. Egberink HF, Ederveen J, Callebaut P, Horzinek MC: Characterization of the structural proteins of porcine epizootic diarrhea virus, strain CV777. Am J Vet Res 1988, 49:1320-1324.
8. Bridgen A, Kocherhans R, Tobler K, Carvajal A, Ackermann M: Further analysis of the genome of porcine epidemic diarrhoea virus. Adv Exp Med Biol 1998, 440:781-786.
9. Kocherhans R, Bridgen A, Ackermann M, Tobler K: Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence. Virus Genes 2001, 23:137-144.
10. Locker JK, Rose JK, Horzinek MC, Rottier PJ: Membrane assembly of the triple-spanning coronavirus M protein. Individual transmembrane domains show preferred orientation. J Biol Chem 1992, 267:21911-21918.
11. Yeo SG, Hernandez M, Krell PJ, Nagy EE: Cloning and sequence analysis of the spike gene of porcine epidemic diarrhea virus Chinju99. Virus Genes 2003, 26:239-246.
12. Ortego J, Ceriani JE, Patiño C, Plana J, Enjuanes L: Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway. Virology 2007, 368:296-308.
13. Schierack P, Nordhoff M, Pollmann M, Weyrauch KD, Amasheh S, Lodemann U, Jores J, Tachu B, Kleta S, Blikslager A, et al: Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine. Histochem Cell Biol 2005, 125:293-305.
14. Todd DJ, Lee A-H, Glimcher LH: The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 2008, 8:663-674.
15. Zhang K, Kaufman RJ: From endoplasmic-reticulum stress to the inflammatory response. Nature 2008, 454:455-462.
16. Luppi F, Longo AM, de Boer WI, Rabe KF, Hiemstra PS: Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation. Lung Cancer 2007, 56:25-33.
17. Waugh DJ, Wilson C: The interleukin-8 pathway in cancer. Clin Cancer Res 2008, 14:6735-6741.
18. Hong M: Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation. J Biol Chem 2005, 280:16821-16828.
19. Li J, Ni M, Lee B, Barron E, Hinton DR, Lee AS: The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ 2008, 15:1460-1471.
20. Quinones QJ, de Ridder GG, Pizzo SV: GRP78: a chaperone with diverse roles beyond the endoplasmic reticulum. Histol Histopathol 2008, 23:1409-1416.
21. Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M: Multiple control of interleukin-8 gene expression. J Leukoc Biol 2002, 72:847-855.
22. Waris G, Tardif KD, Siddiqui A: Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3. Biochem Pharmacol 2002, 64:1425-1430.
23. Fahy BN, Schlieman MG, Mortenson MM, Virudachalam S, Bold RJ: Targeting BCL-2 overexpression in various human malignancies through NF-κB inhibition by the proteasome inhibitor bortezomib. Cancer Chemother Pharmacol 2005, 56:46-54.
24. Ricca A, Biroccio A, Del Bufalo D, Mackay AR, Santoni A, Cippitelli M: Bcl-2 over-expression enhances NF-kappaB activity and induces mmp-9 transcription in human MCF7(ADR) breast-cancer cells. Int J Cancer 2000, 86:188-196.
25. Batsi C, Markopoulou S, Kontargiris E, Charalambous C, Thomas C, Christoforidis S, Kanavaros P, Constantinou AI, Marcu KB, Kolettas E: Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27Kip1-dependent G1/S cell cycle arrest in conjunction with NF-kκB activation. Biochem Pharmacol 2009, 78:33-44.
26. Seo M, Nam H-J, Kim S-Y, Juhnn Y-S: Inhibitory heterotrimeric GTP-binding proteins inhibit hydrogen peroxide-induced apoptosis by up-regulation of Bcl-2 via NF-κB in H1299 human lung cancer cells. Biochem Biophys Res Commun 2009, 381:153-158.
27. Junwei G, Baoxian L, Lijie T, Yijing L: Cloning and sequence analysis of the N gene of porcine epidemic diarrhea virus LJB/03. Virus Genes 2006, 33:215-219.
28. Chen J, Wang C, Shi H, Qiu HJ, Liu S, Shi D, Zhang X, Feng L: Complete genome sequence of a chinese virulent porcine epidemic diarrhea virus strain. J Virol 2011, 85:11538-11539.
29. Park SJ, Kim HK, Song DS, An DJ, Park BK: Complete genome sequences of a korean virulent porcine epidemic diarrhea virus and its attenuated counterpart. J Virol 2012, 86:5964.
30. Anelli T, Sitia R: Protein quality control in the early secretory pathway. EMBO J 2008, 27:315-327.
31. Li Q, Verma IM: NF-κB regulation in the immune system. Nat Rev Immunol 2002, 2:725-734.
32. Wietek C, O'Neill LAJ: Diversity and regulation in the NF-κB system. Trends Biochem Sci 2007, 32:311-319.
33. Geng H, Wittwer T, Dittrich-Breiholz O, Kracht M, Schmitz ML: Phosphorylation of NF-κB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination. EMBO Rep 2009, 10:381-386.
34. Honglei Z, Jie D, Yabing L, Xingang X, Dewen T: RT-PCR identification of porcine epidemic diarrhea virus and sequence analysis of its M, N and E gene. Acta Agriculturae Boreali-occidentalis Sinica 2012, 21:24-28.
35. Jing W, Yanming Z, Gang T, Fangning L, Hongchao Z, Lei H, Xiaoyun Y, Yanzhao X, Haixia H: The isolation and identification of neonatal swine intestinal epithelial cells. Acta Veterinaria et Zootechnica Sinica 2010, 41:92-98.
36. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 - ΔΔCT method. Methods 2001, 25:402-408.
37. Matsuo Y, Sawai H, Ochi N, Yasuda A, Sakamoto M, Takahashi H, Funahashi H, Takeyama H, Guha S: Proteasome inhibitor MG132 inhibits angiogenesis in pancreatic cancer by blocking NF-κB activity.Dig Dis Sci 2009, 55:1167-1176.