4-Aminopyridine suppresses positional nystagmus caused by cerebellar vermis lesion

Journal of Neurology

Volumn 260, Issue 1, 2013, Pages 321-323

  Kremmyda, O ^a,b   Zwergal, A ^a,b   La Fougere C ^b   Brandt, T ^b   Jahn, K ^a,b   Strupp, M ^a,b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; FLUORODEOXYGLUCOSE F 18;

ADULT; BODY MOVEMENT; BODY POSITION; CANCER SURGERY; CASE REPORT; CEREBELLUM VERMIS; EYE EXAMINATION; EYE MOVEMENT; FEMALE; HEAD MOVEMENT; HEMANGIOBLASTOMA; HUMAN; LETTER; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; NYSTAGMUS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SUPINE POSITION; TREATMENT OUTCOME; VERTIGO;

4-AMINOPYRIDINE; CEREBELLAR DISEASES; CONTRAST MEDIA; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; NYSTAGMUS, PATHOLOGIC; POSITRON-EMISSION TOMOGRAPHY; POTASSIUM CHANNEL BLOCKERS;

EID: 84872316331     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-012-6737-6     Document Type: Letter

References (10)

1. Büttner U, Helmchen C, Brandt T (1999) Diagnostic criteria for central versus peripheral positioning nystagmus and vertigo: a review. Acta Otolaryngol 119:1-5
2. Etzion Y, Grossman Y (2001) Highly 4-aminopyridine sensitive delayed rectifier current modulates the excitability of guinea pig cerebellar Purkinje cells. Exp Brain Res 139:419-425
3. Halmagyi GM, Rudge P, Gresty MA, Sanders MD (1983) Downbeating nystagmus. A review of 62 cases. Arch Neurol 40:777-784
4. Kattah JC, Kolsky MP, Luessenhop AJ (1984) Positional vertigo and the cerebellar vermis. Neurology 34:527-529
5. Marti S, Palla A, Straumann D (2002) Gravity dependence of ocular drift in patients with cerebellar downbeat nystagmus. Ann Neurol 52:712-721
6. Sato H, Noda H (1992) Posterior vermal Purkinje cells in macaques responding during saccades, smooth pursuit, chair rotation and/or optokinetic stimulation. Neurosci Res 12:583-595
7. Strupp M, Kalla R, Claassen J, Adrion C, Mansmann U, Klopstock T, Freilinger T, Neugebauer H, Spiegel R, Dichgans M, Lehmann-Horn F, Jurkat-Rott K, Brandt T, Jen JC, Jahn K (2011) A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias. Neurology 77:269-275
8. Strupp M, Schuler O, Krafczyk S, Jahn K, Schautzer F, Buttner U, Brandt T (2003) Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study. Neurology 61:165-170
9. Yamada J, Noda H (1987) Afferent and efferent connections of the oculomotor cerebellar vermis in the macaque monkey. J Comp Neurol 265:224-241
10. Zee DS, Friendlich AR, Robinson DA (1974) The mechanism of downbeat nystagmus. Arch Neurol 30:227-237