Application of Heart-Cutting 2D-LC for the Determination of Peak Purity for a Chiral Pharmaceutical Compound by HPLC

Chromatographia

Volumn 76, Issue 1-2, 2013, Pages 5-11

  Lee, Claire ^a   Zang, Jia ^a   Cuff, James ^a   McGachy, Neil ^a   Natishan, Theresa K ^a   Welch, Christopher J ^a   Helmy, Roy ^a   Bernardoni, Frank ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

2D LC; Heart cutting HPLC; Method validation; Peak purity assessment; Pharmaceutical analysis; Two dimensional HPLC

Indexed keywords

NEW DRUG;

ARTICLE; CHIRALITY; COMPUTER PROGRAM; CONCENTRATION (PARAMETERS); DRUG IMPURITY; DRUG PURITY; HEART CUTTING TWO DIMENSIONAL LIQUID CHROMATOGRAPHY TECHNIQUE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SEPARATION TECHNIQUE; STEREOISOMERISM; TEMPERATURE; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

EID: 84872314877     PISSN: 00095893     EISSN: 16121112     Source Type: Journal    
DOI: 10.1007/s10337-012-2367-5     Document Type: Article

References (22)

1. Kazakevich Y, Lobrutto R (eds) (2007) HPLC for pharmaceutical scientists. Wiley, Hoboken
2. Ahuja S, Rasmussen H (eds) (2007) HPLC method development for pharmaceuticals, 8th edn. Elsevier, Oxford
3. Lunn G (2005) HPLC methods for recently approved pharmaceuticals. Wiley, Hoboken
4. Natishan TK (2011) J Liq Chromatogr Relat Technol 34:1133-1156
5. Dobo KL, Greene N, Cyr MO, Caron S, Ku WW (2006) Regul Toxicol Pharmacol 44:282-293
6. McGovern T, Jacobson-Kram D (2006) Trends Anal Chem 25:790-795 (Pubitemid 44291461)
7. Robinson DI (2010) Org Process Res Dev 14:946-959
8. Fabre H, Bris AL, Blanchin MD (1995) J Chromatogr A 697:81-88
9. Wiberg K, Andersson M, Hagman A, Jacobsson SP (1029) J Chromatogr A 2004:13-20
10. Papadoyannis IN, Gika HG (2004) J Liq Chromatogr Relat Technol 27:1083-1092
11. Huber L, George SA (1993) Diode array detection in HPLC. Marvcel Dekker Inc., New York
12. Bryant DK, Kingswood MD, Belenguer A (1996) J Chromatogr A 721:41-51 (Pubitemid 26039814)
13. Lincoln D, Fell AF, Anderson NH, England D (1992) J Pharm Biomed Anal 10:837-844 (Pubitemid 23080441)
14. Bylund D, Danielsson R, Markides KE (2001) J Chromatogr A 915:43-52 (Pubitemid 32289324)
15. Lun DS, Jennings LD, Koetter R, Licht S, Medard M (2007) J Chem Inf Model 47:1973-1978 (Pubitemid 47561145)
16. Sanchez FC, Khots MS, Massart DL (1994) Beer., J. O. D. Anal Chim Acta 285:181-192 (Pubitemid 24073551)
17. Sanchez FC, Khots MS, Massart DL (1994) Anal Chim Acta 290:249-258 (Pubitemid 24154437)
18. Castledine JB, Fell AF (1993) J Pharm Biomed Anal 11:1-13 (Pubitemid 23085142)
19. Dugo P, Favoino O, Luppino R, Dugo G, Mondello L (2004) Anal Chem 76:2525-2530 (Pubitemid 38585719)
20. Dugo P, Cacciola F, Kumm T, Dugo G, Mondello L (2008) J Chromatogr A 1184:353-368 (Pubitemid 351296208)
21. Guiochon G, Marchetti N, Mriziq K, Shalliker RA (2008) J Chromatogr A 1189:109-168
22. Shellie RA, Haddad PR (2006) Anal Bioanal Chem 386:405-415 (Pubitemid 44450922)