LysR family activator-regulated major facilitator superfamily transporters are involved in Vibrio cholerae antimicrobial compound resistance and intestinal colonisation

International Journal of Antimicrobial Agents

Volumn 41, Issue 2, 2013, Pages 188-192

  Chen, Sushu ^a   Wang, Hui ^a   Katzianer, David S ^b   Zhong, Zengtao ^a   Zhu, Jun ^a,b  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Antimicrobial compound; Colonisation; LysR type; Major facilitator superfamily; Vibrio cholerae

Indexed keywords

BACTERIAL PROTEIN; MAJOR FACILITATOR SUPERFAMILY PROTEIN; MAJOR FACILITATOR SUPERFAMILY REGULATOR; REGULATOR PROTEIN; TETRACYCLINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL STRAIN; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE STRUCTURE; GENETIC TRANSCRIPTION; HOST PATHOGEN INTERACTION; MAJOR FACILITATOR SUPERFAMILY 1 GENE; MAJOR FACILITATOR SUPERFAMILY 2 GENE; MAJOR FACILITATOR SUPERFAMILY 3 GENE; MAJOR FACILITATOR SUPERFAMILY 4 GENE; MAJOR FACILITATOR SUPERFAMILY 5 GENE; MAJOR FACILITATOR SUPERFAMILY REGULATOR 1 GENE; MAJOR FACILITATOR SUPERFAMILY REGULATOR 2 GENE; MAJOR FACILITATOR SUPERFAMILY REGULATOR 3 GENE; MAJOR FACILITATOR SUPERFAMILY REGULATOR 4 GENE; MAJOR FACILITATOR SUPERFAMILY REGULATOR 5 GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; VIBRIO CHOLERAE; WILD TYPE;

ANIMALS; ANTI-BACTERIAL AGENTS; BILE ACIDS AND SALTS; CHOLERA; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; MEMBRANE TRANSPORT PROTEINS; MICE; TETRACYCLINE; TRANSCRIPTION FACTORS; VIBRIO CHOLERAE; VIRULENCE;

EID: 84872309827     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2012.10.008     Document Type: Article

References (15)

1. S.S. Pao, I.T. Paulsen, and M.H. Saier Jr. Major facilitator superfamily Microbiol Mol Biol Rev 62 1998 1 34 (Pubitemid 28130794)
2. M. Kitaoka, S.T. Miyata, D. Unterweger, and S. Pukatzki Antibiotic resistance mechanisms of Vibrio cholerae J Med Microbiol 60 2011 397 407
3. X.R. Bina, D. Provenzano, N. Nguyen, and J.E. Bina Vibrio cholerae RND family efflux systems are required for antimicrobial resistance, optimal virulence factor production, and colonization of the infant mouse small intestine Infect Immun 76 2008 3595 3605
4. D.L. Taylor, X.R. Bina, and J.E. Bina Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilus PLoS ONE 7 2012 e38208
5. F.A. Cerda-Maira, C.S. Ringelberg, and R.K. Taylor The bile response repressor BreR regulates expression of the Vibrio cholerae breAB efflux system operon J Bacteriol 190 2008 7441 7452
6. S.E. Maddocks, and P.C. Oyston Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins Microbiology 154 2008 3609 3623
7. Z. Liu, M. Yang, G.L. Peterfreund, A.M. Tsou, N. Selamoglu, and F. Daldal Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB Proc Natl Acad Sci USA 108 2011 810 815
8. W.W. Metcalf, W. Jiang, L.L. Daniels, S.K. Kim, A. Haldimann, and B.L. Wanner Conditionally replicative and conjugative plasmids carrying lacZα for cloning, mutagenesis, and allele replacement in bacteria Plasmid 35 1996 1 13 (Pubitemid 26066220)
9. B.K. Hammer, and B.L. Bassler Regulatory small RNAs circumvent the conventional quorum sensing pathway in pandemic Vibrio cholerae Proc Natl Acad Sci USA 104 2007 11145 11149 (Pubitemid 47175108)
10. L.M. Guzman, D. Belin, M.J. Carson, and J. Beckwith Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter J Bacteriol 177 1995 4121 4130
11. C.L. Gardel, and J.J. Mekalanos Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression Infect Immun 64 1996 2246 2255 (Pubitemid 26165686)
12. M. Begley, C.G. Gahan, and C. Hill The interaction between bacteria and bile FEMS Microbiol Rev 29 2005 625 651 (Pubitemid 41139175)
13. J.S. Gunn Mechanisms of bacterial resistance and response to bile Microbes Infect 2 2000 907 913 (Pubitemid 30483186)
14. S. Coyne, P. Courvalin, and B. Perichon Efflux-mediated antibiotic resistance in Acinetobacter spp. Antimicrob Agents Chemother 55 2011 947 953
15. M.J. Lombardo, J. Michalski, H. Martinez-Wilson, C. Morin, T. Hilton, and C.G. Osorio An in vivo expression technology screen for Vibrio cholerae genes expressed in human volunteers Proc Natl Acad Sci USA 104 2007 18229 18234 (Pubitemid 350210849)