The role of mitochondrial calcium uniporter in neuroprotection in traumatic brain injury

Medical Hypotheses

Volumn 80, Issue 2, 2013, Pages 115-117

  Cheng, Gang ^a   Fu, Luo'an ^b   Zhang, Hang yu ^b   Wang, Ya ming ^a   Zhang, Lei ming ^a   Zhang, Jian ning ^a  

^a NAVY GENERAL HOSPITAL   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CARRIER PROTEIN; MINOCYCLINE; MITOCHONDRIAL CALCIUM UNIPORTER; NECROX 5; PROTEIN INHIBITOR; RU 360; RUTHENIUM RED; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CALCIUM TRANSPORT; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HEART PROTECTION; HUMAN; MITOCHONDRION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; TRAUMATIC BRAIN INJURY;

BRAIN INJURIES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM SIGNALING; CELL DEATH; HUMANS; MODELS, BIOLOGICAL; NEUROPROTECTIVE AGENTS;

EID: 84872306380     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.11.004     Document Type: Article

References (29)

1. Langham J, Goldfrad C, Teasdale G, Shaw D, Rowan K. Calcium channel blockers for acute traumatic brain injury. Cochrane Database Syst Rev 2003 [CD000565].
2. Baughman J.M., Perocchi F., Girgis H.S., et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 2011, 476:341-345.
3. De Stefani D., Raffaello A., Teardo E., Szabo I., Rizzuto R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 2011, 476:336-340.
4. Weber J.T. Altered calcium signaling following traumatic brain injury. Front Pharmacol 2012, 3:60.
5. Spat A., Szanda G., Csordas G., Hajnoczky G. High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling. Cell Calcium 2008, 44:51-63.
6. Ye T.M., Zhang S.Z., Xia Q. Role of mitochondrial calcium uniporter in myocardial hypoxia/reoxygenation induced injury. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2006, 22:136-140.
7. Correa F., Soto V., Zazueta C. Mitochondrial permeability transition relevance for apoptotic triggering in the post-ischemic heart. Int J Biochem Cell Biol 2007, 39:787-798.
8. Thu V.T., Kim H.K., Long le T., et al. NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter. Cardiovasc Res 2012, 94:342-350.
9. de Jesus Garcia-Rivas G, Guerrero-Hernandez A, Guerrero-Serna G, Rodriguez-Zavala JS, Zazueta C. Inhibition of the mitochondrial calcium uniporter by the oxo-bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in postischemic rat heart, FEBS J 2005;272:3477-88.
10. Sun Y., Deng T., Lu N., Yan M., Zheng X. B-type natriuretic peptide protects cardiomyocytes at reperfusion via mitochondrial calcium uniporter. Biomed Pharmacother 2010, 64:170-176.
11. Zhang S.Z., Gao Q., Cao C.M., Bruce I.C., Xia Q. Involvement of the mitochondrial calcium uniporter in cardioprotection by ischemic preconditioning. Life Sci 2006, 78:738-745.
12. Sloan R.C., Moukdar F., Frasier C.R., et al. Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury. J Mol Cell Cardiol 2012, 52:1009-1018.
13. Kambe Y., Nakamichi N., Takarada T., et al. A possible pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-d-aspartate receptors in cultured rat hippocampal neurons. Neurochem Int 2011, 59:10-20.
14. Tirosh O., Sen C.K., Roy S., Packer L. Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death. Neuroscience 2000, 97:531-541.
15. 2+ mobilization promotes cytochrome c release during apoptosis. J Biol Chem 2002, 277:20301-20308.
16. 2+ stores. J Biol Chem 2002, 277:9219-9225.
17. Vanderluit J.L., McPhail L.T., Fernandes K.J., Kobayashi N.R., Tetzlaff W. In vivo application of mitochondrial pore inhibitors blocks the induction of apoptosis in axotomized neonatal facial motoneurons. Cell Death Differ 2003, 10:969-976.
18. Yarana C., Sanit J., Chattipakorn N., Chattipakorn S. Synaptic and nonsynaptic mitochondria demonstrate a different degree of calcium-induced mitochondrial dysfunction. Life Sci 2012, 90:808-814.
19. Thomas A.P., Bird G.S., Hajnoczky G., Robb-Gaspers L.D., Putney J.W. Spatial and temporal aspects of cellular calcium signaling. FASEB J 1996, 10:1505-1517.
20. Santo-Domingo J., Demaurex N. Calcium uptake mechanisms of mitochondria. Biochim Biophys Acta 2010, 1797:907-912.
21. Duchen M.R., Verkhratsky A., Muallem S. Mitochondria and calcium in health and disease. Cell Calcium 2008, 44:1-5.
22. Nicholls D.G. Mitochondrial calcium function and dysfunction in the central nervous system. Biochim Biophys Acta 2009, 1787:1416-1424.
23. 2+ concentration. Curr Biol 2006, 16:1672-1677.
24. Putney J.W., Thomas A.P. Calcium signaling: double duty for calcium at the mitochondrial uniporter. Curr Biol 2006, 16:R812-R815.
25. Vergun O., Votyakova T.V., Reynolds I.J. Spontaneous changes in mitochondrial membrane potential in single isolated brain mitochondria. Biophys J 2003, 85:3358-3366.
26. Peng T.I., Jou M.J. Oxidative stress caused by mitochondrial calcium overload. Ann NY Acad Sci 2010, 1201:183-188.
27. Roy S.S., Hajnoczky G. Calcium, mitochondria and apoptosis studied by fluorescence measurements. Methods 2008, 46:213-223.
28. Zhou J., Cheng G., Kong R., Gao D.K., Zhang X. The selective ablation of inflammation in an acute stage of ischemic stroke may be a new strategy to promote neurogenesis. Med Hypotheses 2011, 76:1-3.
29. Drago I., Pizzo P., Pozzan T. After half a century mitochondrial calcium in- and efflux machineries reveal themselves. EMBO J 2011, 30:4119-4125.