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Volumn 21, Issue 3, 2013, Pages 632-642
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Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin- 2-amines as a new class of tubulin polymerization inhibitors
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Author keywords
Colchicine binding site; Cytotoxicity; N Alkyl N phenylpyridin 2 amines; Tubulin polymerization inhibitors
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Indexed keywords
6 CHLORO 2 [N (4 METHOXYPHENYL) N METHYL]AMINONICOTINIC ACID;
6 CHLORO 3 CYANO N (4 METHOXYPHENYL) N METHYLPYRIDIN 2 AMINE;
6 CHLORO N (3,4 DIMETHOXYPHENYL) N METHYL 3 NITROPYRIDIN 2 AMINE;
6 CHLORO N (4 METHOXYPHENYL) N METHYL 3 NITROPYRIDIN 2 AMINE;
6 CHLORO N CYCLOPENTYL N (4 METHOXYPHENYL) 3 NITROPYRIDIN 2 AMINE;
6 CHLORO N METHYL 3 NITRO N (3,4,5 TRIMETHOXYPHENYL)PYRIDIN 2 AMINE;
6 CHLORO N METHYL 3 NITRO N (4 METHOXYCARBONYLPHENYL) 3 NITROPYRIDIN 2 AMINE;
6 CHLORO N METHYL 3 NITRO N (4 TRIFLUOROMETHOXYPHENYL)PYRIDIN 2 AMINE;
6 METHOXY N (4 METHOXYPHENYL) N METHYL 3 NITROPYRIDIN 2 AMINE;
ANTINEOPLASTIC AGENT;
COLCHICINE;
METHYL 2 [N (4 METHOXYPHENYL) N METHYL]AMINO 6 METHYLAMINONICOTINATE;
METHYL 6 CHLORO 2 [N (4 METHOXYPHENYL) N METHYL]AMINONICOTINATE;
N (4 METHOXYPHENYL) N METHYL 6 METHYL 3 NITROPYRIDIN 2 AMINE;
N (4 METHOXYPHENYL)PYRIDIN 2 AMINE DERIVATIVE;
TUBULIN;
TUBULIN POLYMERIZATION INHIBITOR;
UNCLASSIFIED DRUG;
VINCRISTINE;
ANTINEOPLASTIC ACTIVITY;
ANTIPROLIFERATIVE ACTIVITY;
ARTICLE;
BINDING COMPETITION;
BINDING SITE;
CARBON NUCLEAR MAGNETIC RESONANCE;
CELL ASSAY;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
DRUG CYTOTOXICITY;
DRUG DESIGN;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
IC 50;
MICROTUBULE ASSEMBLY;
MOLECULAR MODEL;
PROTON NUCLEAR MAGNETIC RESONANCE;
TUMOR CELL LINE;
AMINES;
DOSE-RESPONSE RELATIONSHIP, DRUG;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
POLYMERIZATION;
PYRIDINES;
STRUCTURE-ACTIVITY RELATIONSHIP;
TUBULIN;
TUBULIN MODULATORS;
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EID: 84872303107
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2012.11.047 Document Type: Article |
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Times cited : (26)
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References (22)
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