Continuous 13C-methacetin breath test differentiates biliary atresia from other causes of neonatal cholestasis

Journal of Pediatric Gastroenterology and Nutrition

Volumn 56, Issue 1, 2013, Pages 60-65

  Shteyer, Eyal ^a   Lalazar, Gadi ^b   Hemed, Nilla ^b   Pappo, Orit ^a   Granot, Esther ^c   Yerushalmi, Baruch ^d   Gross, Eitan ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b Liver Unit   (Israel)

^c KAPLAN MEDICAL CENTER   (Israel)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

biliary atresia; diagnosis; methacetin breath test; neonatal cholestasis

Indexed keywords

4 ACETANISIDINE; 4 ACETANISIDINE CARBON 13; CYTOCHROME P450 1A2; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; BILE DUCT ATRESIA; BREATH ANALYSIS; CHOLESTASIS; CLINICAL ARTICLE; DIAGNOSTIC ACCURACY; FEMALE; HUMAN; HUMAN TISSUE; INFANT; LIVER FUNCTION TEST; MALE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ACETAMIDES; AREA UNDER CURVE; BILE DUCTS; BILIARY ATRESIA; BREATH TESTS; CARBON DIOXIDE; CARBON ISOTOPES; CHOLESTASIS; CONFIDENCE INTERVALS; CYTOCHROME P-450 CYP1A2; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; INFANT; LIVER; LIVER CIRRHOSIS, BILIARY; LIVER FUNCTION TESTS; MALE; SENSITIVITY AND SPECIFICITY;

EID: 84872293166     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0b013e3182638d29     Document Type: Article

References (37)

1. Balistreri WF. Neonatal cholestasis. J Pediatr 1985;106:171-84.
2. Ilan Y. Review article: the assessment of liver function using breath tests. Aliment Pharmacol Ther 2007;26:1293-302.
3. Schneider A, Caspary WF, Saich R, et al. 13C-Methacetin breath test shortened: 2-point-measurements after 15minutes reliably indicate the presence of liver cirrhosis. J Clin Gastroenterol 2007;41:33-7.
4. Hepner GW, Vesell ES. Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis. N Engl J Med 1974;291:1384-8.
5. Utecht KN, Hiles JJ, Kolesar J. Effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors. Am J Health Syst Pharm 2006;63:2340-8.
6. Liu L, Pang KS. An integrated approach to model hepatic drug clearance. Eur J Pharm Sci 2006;29:215-30.
7. Klatt S, Taut C, Mayer D, et al. Evaluation of the 13C-methacetin breath test for quantitative liver function testing. Z Gastroenterol 1997; 35:609-14.
8. Guengerich FP, Krauser JA, Johnson WW. Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P450 1A2. Biochemistry 2004;43:10775-88.
9. Nakai K, Tanaka H, Hanada K, et al. Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients. Drug Metab Dispos 2008;36:1786-93.
10. Congiu M, Mashford ML, Slavin JL, et al. UDP glucuronosyltransferase mRNA levels in human liver disease. Drug Metab Dispos 2002;30: 129-34.
11. Crawford JH, Yang S, Zhou M, et al. Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis. Crit Care Med 2004;32:502-8.
12. Goetze O, Selzner N, Fruehauf H, et al. 13C-Methacetin breath test as a quantitative liver function test in patients with chronic hepatitis C infection: continuous automatic molecular correlation spectroscopy compared to isotopic ratio mass spectrometry. Aliment Pharmacol Ther 2007;26:305-11.
13. Israeli E, Ilan Y, Meir SB, et al. A novel 13C-urea breath test device for the diagnosis of Helicobacter pylori infection: continuous online measurements allow for faster test results with high accuracy. J Clin Gastroenterol 2003;37:139-41.
14. Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-9.
15. Nista EC, Fini L, Armuzzi A, et al. 13C-breath tests in the study of microsomal liver function. Eur Rev Med Pharmacol Sci 2004;8:33-46.
16. Mieli-Vergani G, Howard ER, Portman B, et al. Late referral for biliary atresia-missed opportunities for effective surgery. Lancet 1989; 1:421-3.
17. Davenport M, Kerkar N, Mieli-Vergani G, et al. Biliary atresia: the King's College Hospital experience (1974-1995). J Pediatr Surg 1997;32:479-85.
18. Gilmour SM, Hershkop M, Reifen R, et al. Outcome of hepatobiliary scanning in neonatal hepatitis syndrome. J Nucl Med 1997;38:1279-82.
19. Keil R, Snajdauf J, Rygl M, et al. Diagnostic efficacy of ERCP in cholestatic infants and neonates-a retrospective study on a large series. Endoscopy 2010;42:121-6.
20. Iinuma Y, Narisawa R, Iwafuchi M, et al. The role of endoscopic retrograde cholangiopancreatography in infants with cholestasis. J Pediatr Surg 2000;35:545-9.
21. Azar G, Beneck D, Lane B, et al. Atypical morphologic presentation of biliary atresia and value of serial liver biopsies. J Pediatr Gastroenterol Nutr 2002;34:212-5.
22. Nord KS, Saad S, Joshi VV, et al. Concurrence of alpha 1-antitrypsin deficiency and biliary atresia. J Pediatr 1987;111:416-8.
23. Amedee-Manesme O, Bernard O, Brunelle F, et al. Sclerosing cholangitis with neonatal onset. J Pediatr 1987;111:225-9.
24. Shapira R, Hadzic N, Francavilla R, et al. Retrospective review of cystic fibrosis presenting as infantile liver disease. Arch Dis Child 1999; 81:125-8.
25. Herbarth O, Franck U, Krumbiegel P, et al. Noninvasive assessment of liver detoxification capacity of children, observed in children from heavily polluted industrial and clean control areas, together with assessments of air pollution and chloro-organic body burden. Environ Toxicol 2004;19:103-8.
26. Krumbiegel P, Domke S, Morseburg B, et al. Maturation of hepatosomal mono-oxygenation and glucuronidation activities in pre-and full-term infants as studied using the [15N]methacetin urine test. Acta Paediatr 1997;86:1236-40.
27. Braden B, Faust D, Sarrazin U, et al. 13C-Methacetin breath test as liver function test in patients with chronic hepatitis C virus infection. Aliment Pharmacol Ther 2005;21:179-85.
28. Matsumoto K, Suehiro M, Iio M, et al. [13C]methacetin breath test for evaluation of liver damage. Dig Dis Sci 1987;32:344-8.
29. Tang KS, Huang LT, Huang YH, et al. Gamma-glutamyl transferase in the diagnosis of biliary atresia. Acta Paediatr Taiwan 2007;48:196-200.
30. Rendon-Macias ME, Villasis-Keever MA, Castaneda-Mucino G, et al. Improvement in accuracy of gamma-glutamyl transferase for differential diagnosis of biliary atresia by correlation with age. Turk J Pediatr 2008;50:253-9.
31. Shirin H, Aeed H, Shalev T, et al. Utility of a 13C-methacetin breath test in evaluating hepatic injury in rats. J Gastroenterol Hepatol 2008;23:1762-8.
32. Lalazar G, Pappo O, Hershcovici T, et al. A continuous 13C methacetin breath test for noninvasive assessment of intrahepatic inflammation and fibrosis in patients with chronic HCV infection and normal ALT. J Viral Hepat 2008;15:716-28.
33. Ratanasavanh D, Beaune P, Morel F, et al. Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age. Hepatology 1991;13:1142-51.
34. Sonnier M, Cresteil T. Delayed ontogenesis of CYP1A2 in the human liver. Eur J Biochem 1998;251:893-8.
35. Li J, Bessho K, Shivakumar P, et al. Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype. J Clin Invest 2011;121:4244-56.
36. Shivakumar P, Sabla G, Mohanty S, et al. Effector role of neonatal hepatic CD8 lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology 2007;133:268-77.
37. Faber MS, Jetter A, Fuhr U. Assessment of CYP1A2 activity in clinical practice: why, how, and when? Basic Clin Pharmacol Toxicol 2005; 97:125-34.