The effect of acute exercise in hypoxia on flow-mediated vasodilation

European Journal of Applied Physiology

Volumn 113, Issue 2, 2013, Pages 349-357

  Katayama, Keisho ^a   Fujita, Osamu ^a   Iemitsu, Motoyuki ^b   Kawano, Hiroshi ^c   Iwamoto, Erika ^d   Saito, Mitsuru ^e   Ishida, Koji ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b RITSUMEIKAN UNIVERSITY   (Japan)

^c WASEDA UNIVERSITY   (Japan)

^d NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

Aerobic exercise; Flow mediated dilation; Hypoxia; Vasodilation

Indexed keywords

ADULT; ANOXIA; ARTICLE; BLOOD FLOW VELOCITY; BRACHIAL ARTERY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENDURANCE; EXERCISE; HUMAN; MALE; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; VASODILATATION;

ANOXIA; BLOOD FLOW VELOCITY; BRACHIAL ARTERY; HUMANS; MALE; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; PHYSICAL EXERTION; VASODILATION; YOUNG ADULT;

EID: 84872289949     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-012-2442-5     Document Type: Article

References (58)

1. Babcock M, Shkoukani M, Aboubakr SE, Badr MS (2003) Determinants of long-term facilitation in humans during NREM sleep. J Appl Physiol 94:53-59
2. Black MA, Cable NT, Thijssen DH, Green DJ (2008) Importance of measuring the time course of flow-mediated dilatation in humans. Hypertension 51:203-210
3. Blitzer ML, Lee SD, Creager MA (1996) Endothelium-derived nitric oxide mediates hypoxic vasodilation of resistance vessels in humans. Am J Physiol 271:H1182-H1185
4. Borg GAV (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14:377-381
5. Casey DP, Madery BD, Curry TB, Eisenach JH, Wilkins BW, Joyner MJ (2010) Nitric oxide contributes to the augmented vasodilatation during hypoxic exercise. J Physiol 588:373-385
6. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R (2002) Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 39:257-265
7. Cosio-Lima LM, Thompson PD, Reynolds KL, Headley SA, Winter CR, Manos T, Lagasse MA, Todorovich JR, Germain M (2006) The acute effect of aerobic exercise on brachial artery endothelial function in renal transplant recipients. Prev Cardiol 9:211-214
8. Dawson EA, Whyte GP, Black MA, Jones H, Hopkins N, Oxborough D, Gaze D, Shave RE, Wilson M, George KP, Green DJ (2008) Changes in vascular and cardiac function after prolonged strenuous exercise in humans. J Appl Physiol 105:1562-1568
9. Delp MD, Laughlin MH (1998) Regulation of skeletal muscle perfusion during exercise. Acta Physiol Scand 162:411-419
10. Edmunds NJ, Marshall JM (2001) Vasodilatation, oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: roles of nitric oxide. J Physiol 532:251-259
11. Edwards DG, Schofield RS, Lennon SL, Pierce GL, Nichols WW, Braith RW (2004) Effect of exercise training on endothelial function in men with coronary artery disease. Am J Cardiol 93:617-620
12. Frick M, Rinner A, Mair J, Alber HF, Mittermayr M, Pachinger O, Humpeler E, Schobersberger W, Weidinger F (2006) Transient impairment of flow-mediated vasodilation in patients with metabolic syndrome at moderate altitude (1,700 m). Int J Cardiol 109:82-87
13. Gielen S, Schuler G, Hambrecht R (2001) Exercise training in coronary artery disease and coronary vasomotion. Circulation 103:E1-E6
14. Gokce N, Vita JA, Bader DS, Sherman DL, Hunter LM, Holbrook M, O'Malley C, Keaney JF Jr, Balady GJ (2002) Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. Am J Cardiol 90:124-127
15. Green D, Cheetham C, Mavaddat L, Watts K, Best M, Taylor R, O'Driscoll G (2002a) Effect of lower limb exercise on forearm vascular function: contribution of nitric oxide. Am J Physiol Heart Circ Physiol 283:H899-H907
16. Green D, Cheetham C, Reed C, Dembo L, O'Driscoll G (2002b) Assessment of brachial artery blood flow across the cardiac cycle: retrograde flows during cycle ergometry. J Appl Physiol 93:361-368
17. Hamdy O, Ledbury S, Mullooly C, Jarema C, Porter S, Ovalle K, Moussa A, Caselli A, Caballero AE, Economides PA, Veves A, Horton ES (2003) Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care 26:2119-2125
18. Harris RA, Padilla J, Rink LD, Wallace JP (2006) Variability of flow-mediated dilation measurements with repetitive reactive hyperemia. Vasc Med 11:1-6
19. Harris RA, Padilla J, Hanlon KP, Rink LD, Wallace JP (2007) Reproducibility of the flow-mediated dilation response to acute exercise in overweight men. Ultrasound Med Biol 33:1579-1585
20. Harvey PJ, Morris BL, Kubo T, Picton PE, Su WS, Notarius CF, Floras JS (2005) Hemodynamic after-effects of acute dynamic exercise in sedentary normotensive postmenopausal women. J Hypertens 23:285-292
21. Iwamoto E, Katayama K, Oshida Y, Ishida K (2012) Hypoxia augments oscillatory blood flow in brachial artery during leg cycling. Med Sci Sports Exerc 44:1035-1042
22. Katayama K, Amann M (2009) Arterial oxygenation and muscle fatigue. In: Shinohara M (ed) Advances in neuromuscular physiology of motor skills and muscle fatigue. Research Signpost, India, pp 327-350
23. Katayama K, Amann M, Pegelow DF, Jacques AJ, Dempsey JA (2007a) Effect of arterial oxygenation on quadriceps fatigability during isolated muscle exercise. Am J Physiol Regul Integr Comp Physiol 292:R1279-R1286
24. Katayama K, Sato K, Hotta N, Ishida K, Iwasaki K, Miyamura M (2007b) Intermittent hypoxia does not increase exercise ventilation at simulated moderate altitude. Int J Sports Med 28:480-487
25. Katayama K, Yoshitake Y, Watanabe K, Akima H, Ishida K (2010) Muscle deoxygenation during sustained and intermittent isometric exercise in hypoxia. Med Sci Sports Exerc 42:1269-1278
26. Katayama K, Ishida K, Iwamoto E, Iemitsu M, Koike T, Saito M (2011) Hypoxia augments muscle sympathetic neural response to leg cycling. Am J Physiol Regul Integr Comp Physiol 301:R456-R464
27. Kooijman M, Thijssen DH, de Groot PC, Bleeker MW, van Kuppevelt HJ, Green DJ, Rongen GA, Smits P, Hopman MT (2008) Flow-mediated dilatation in the superficial femoral artery is nitric oxide mediated in humans. J Physiol 586:1137-1145
28. Leuenberger UA, Gray K, Herr MD (1999) Adenosine contributes to hypoxia-induced forearm vasodilation in humans. J Appl Physiol 87:2218-2224
29. Leuenberger UA, Johnson D, Loomis J, Gray KS, MacLean DA (2008) Venous but not skeletal muscle interstitial nitric oxide is increased during hypobaric hypoxia. Eur J Appl Physiol 102:457-461
30. Maiorana A, O'Driscoll G, Cheetham C, Dembo L, Stanton K, Goodman C, Taylor R, Green D (2001) The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol 38:860-866
31. Marshall JM (2000) Adenosine and muscle vasodilatation in acute systemic hypoxia. Acta Physiol Scand 168:561-573
32. Marshall JM (2001) Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxia. Adv Exp Med Biol 502:349-363
33. Niebauer J, Cooke JP (1996) Cardiovascular effects of exercise: role of endothelial shear stress. J Am Coll Cardiol 28:1652-1660
34. Nishiwaki M, Kawakami R, Saito K, Tamaki H, Takekura H, Ogita F (2011) Vascular adaptations to hypobaric hypoxic training in postmenopausal women. J Physiol Sci 61:83-91
35. Padilla J, Harris RA, Fly AD, Rink LD, Wallace JP (2006) The effect of acute exercise on endothelial function following a high-fat meal. Eur J Appl Physiol 98:256-262
36. Padilla J, Harris RA, Wallace JP (2007) Can the measurement of brachial artery flow-mediated dilation be applied to the acute exercise model? Cardiovasc Ultrasound 5:45
37. Pyke KE, Tschakovsky ME (2005) The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function. J Physiol 568:357-369
38. Pyke KE, Tschakovsky ME (2007) Peak vs. total reactive hyperemia: which determines the magnitude of flow-mediated dilation? J Appl Physiol 102:1510-1519
39. Pyke KE, Poitras V, Tschakovsky ME (2008) Brachial artery flow-mediated dilation during handgrip exercise: evidence for endothelial transduction of the mean shear stimulus. Am J Physiol Heart Circ Physiol 294:H2669-H2679
40. Ray CJ, Marshall JM (2005) Measurement of nitric oxide release evoked by systemic hypoxia and adenosine from rat skeletal muscle in vivo. J Physiol 568:967-978
41. Reboul C, Tanguy S, Dauzat M, Obert P (2005a) Altitude negates the benefits of aerobic training on the vascular adaptations in rats. Med Sci Sports Exerc 37:979-985
42. Reboul C, Tanguy S, Gibault A, Dauzat M, Obert P (2005b) Chronic hypoxia exposure depresses aortic endothelium-dependent vasorelaxation in both sedentary and trained rats: involvement of l-arginine. J Appl Physiol 99:1029-1035
43. Rognmo O, Bjornstad TH, Kahrs C, Tjonna AE, Bye A, Haram PM, Stolen T, Slordahl SA, Wisloff U (2008) Endothelial function in highly endurance-trained men: effects of acute exercise. J Strength Cond Res 22:535-542
44. Rowell LB (1986) Cardiovascular adjustments to hypoxemia. In: Rowell LB (ed) Human circulation: regulation during physical stress. Oxford University Press, New York, pp 328-362
45. Seals DR, Johnson DG, Fregosi RF (1991) Hypoxia potentiates exercise-induced sympathetic neural activation in humans. J Appl Physiol 71:1032-1040
46. Sorensen KE, Celermajer DS, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Thomas O, Deanfield JE (1995) Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. Br Heart J 74:247-253
47. Tanaka H, Bassett DR Jr, Turner MJ (1996) Exaggerated blood pressure response to maximal exercise in endurance-trained individuals. Am J Hypertens 9:1099-1103
48. Tanaka H, Shimizu S, Ohmori F, Muraoka Y, Kumagai M, Yoshizawa M, Kagaya A (2006) Increases in blood flow and shear stress to nonworking limbs during incremental exercise. Med Sci Sports Exerc 38:81-85
49. Thijssen DH, de Groot P, Kooijman M, Smits P, Hopman MT (2006) Sympathetic nervous system contributes to the age-related impairment of flow-mediated dilation of the superficial femoral artery. Am J Physiol Heart Circ Physiol 291:H3122-H3129
50. Thijssen DH, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, Parker B, Widlansky ME, Tschakovsky ME, Green DJ (2011) Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol 300:H2-H12
51. Thompson PD, Crouse SF, Goodpaster B, Kelley D, Moyna N, Pescatello L (2001) The acute versus the chronic response to exercise. Med Sci Sports Exerc 33:S438-S445 (discussion S452-S433)
52. Tinken TM, Thijssen DH, Black MA, Cable NT, Green DJ (2008) Time course of change in vasodilator function and capacity in response to exercise training in humans. J Physiol 586:5003-5012
53. Tinken TM, Thijssen DH, Hopkins N, Black MA, Dawson EA, Minson CT, Newcomer SC, Laughlin MH, Cable NT, Green DJ (2009) Impact of shear rate modulation on vascular function in humans. Hypertension 54:278-285
54. Tschakovsky ME, Joyner MJ (2008) Nitric oxide and muscle blood flow in exercise. Appl Physiol Nutr Metab 33:151-161
55. Tyldum GA, Schjerve IE, Tjonna AE, Kirkeby-Garstad I, Stolen TO, Richardson RS, Wisloff U (2009) Endothelial dysfunction induced by post-prandial lipemia: complete protection afforded by high-intensity aerobic interval exercise. J Am Coll Cardiol 53:200-206
56. Uehata A, Lieberman EH, Gerhard MD, Anderson TJ, Ganz P, Polak JF, Creager MA, Yeung AC (1997) Noninvasive assessment of endothelium-dependent flow-mediated dilation of the brachial artery. Vasc Med 2:87-92
57. Victor RG, Seals DR, Mark AL (1987) Differential control of heart rate and sympathetic nerve activity during dynamic exercise. Insight from intraneural recordings in humans. J Clin Invest 79:508-516
58. Xie A, Skatrud JB, Puleo DS, Morgan BJ (2001) Exposure to hypoxia produces long-lasting sympathetic activation in humans. J Appl Physiol 91:1555-1562