Intratumoral Estrogen Concentration and Expression of Estrogen-Induced Genes in Male Breast Carcinoma: Comparison with Female Breast Carcinoma

Hormones and Cancer

Volumn 4, Issue 1, 2013, Pages 1-11

  Takagi, Kiyoshi ^a   Moriya, Takuya ^b   Kurosumi, Masafumi ^c   Oka, Kimako ^d   Miki, Yasuhiro ^a   Ebata, Akiko ^a   Toshima, Takashi ^d   Tsunekawa, Shoji ^e   Takei, Hiroyuki ^c   Hirakawa, Hisashi ^d   Ishida, Takanori ^a   Hayashi, Shin ichi ^a   Kurebayashi, Junichi ^b   Sasano, Hironobu ^a,f   Suzuki, Takashi ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KAWASAKI MEDICAL SCHOOL   (Japan)

^c SAITAMA CANCER CENTER   (Japan)

^d TOHOKU ROSAI HOSPITAL   (Japan)

^e KANSAI ELECTRIC POWER CO   (Japan)

^f TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1; AROMATASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; KI 67 ANTIGEN; STERYL SULFATASE; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CELL STRAIN MCF 7; ELECTROSPRAY; FEMALE; FEMALE BREAST CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MALE BREAST CARCINOMA; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TANDEM MASS SPECTROMETRY;

EID: 84872282341     PISSN: 18688497     EISSN: 18688500     Source Type: Journal    
DOI: 10.1007/s12672-012-0126-6     Document Type: Article

References (53)

1. Giordano SH, Cohen DS, Buzdar AU, Perkins G, Hortobagyi GN (2004) Breast carcinoma in men: a population-based study. Cancer 101: 51-57.
2. Nahleh Z, Girnius S (2006) Male breast cancer: a gender issue. Nat Clin Pract Oncol 3: 428-437.
3. Suzuki T, Miki Y, Nakamura Y et al (2005) Sex steroid-producing enzymes in human breast cancer. Endocr Relat Cancer 12: 701-720.
4. Frasor J, Danes JM, Komm B, Chang KC, Lyttle CR, Katzenellenbogen BS (2003) Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 144: 4562-4574.
5. Creighton CJ, Cordero KE, Larios JM, Miller RS, Johnson MD, Chinnaiyan AM, Lippman ME, Rae JM (2006) Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors. Genome Biol 7(4): R28, Epub 2006 Apr 7.
6. Suzuki S, Takagi K, Miki Y et al (2012) Nucleobindin 2 in human breast carcinoma as a potent prognostic factor. Cancer Sci 103: 136-143.
7. Leygue E, Dotzlaw H, Watson PH, Murphy LC (1998) Altered estrogen receptor alpha and beta messenger RNA expression during human breast tumorigenesis. Cancer Res 58: 3197-3201.
8. Hayashi SI, Eguchi H, Tanimoto K et al (2003) The expression and function of estrogen receptor alpha and beta in human breast cancer and its clinical application. Endocr Relat Cancer 10: 193-202.
9. Cutuli B, Le-Nir CC, Serin D et al (2010) Male breast cancer. Evolution of treatment and prognostic factors. Analysis of 489 cases. Crit Rev Oncol Hematol 73: 246-254.
10. Rudlowski C, Friedrichs N, Faridi A et al (2004) Her-2/neu gene amplification and protein expression in primary male breast cancer. Breast Cancer Res Treat 84: 215-223.
11. Murphy CE, Carder PJ, Lansdown MR, Speirs V (2006) Steroid hormone receptor expression in male breast cancer. Eur J Surg Oncol 32: 44-47.
12. Shaaban AM, Ball GR, Brannan RA et al (2012) A comparative biomarker study of 514 matched cases of male and female breast cancer reveals gender-specific biological differences. Breast Cancer Res Treat 133: 949-958.
13. Sasano H, Kimura M, Shizawa S, Kimura N, Nagura H (1996) Aromatase and steroid receptors in gynecomastia and male breast carcinoma: an immunohistochemical study. J Clin Endocrinol Metab 81: 3063-3067.
14. Miki Y, Suzuki T, Tazawa C et al (2007) Aromatase localization in human breast cancer tissues: possible interactions between intratumoral stromal and parenchymal cells. Cancer Res 67: 3945-3954.
15. Takagi K, Miki Y, Nagasaki S et al (2010) Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment. Endocr Relat Cancer 17: 415-430.
16. Ebata A, Suzuki T, Takagi K et al (2012) Oestrogen-induced genes in ductal carcinoma in situ (DCIS): their comparison with invasive ductal carcinoma. Endocr Relat Cancer 19: 485-496.
17. Suzuki T, Miki Y, Nakata T et al (2003) Steroid sulfatase and estrogen sulfotransferase in normal human tissue and breast carcinoma. J Steroid Biochem Mol Biol 86: 449-454.
18. Penning TM, Steckelbroeck S, Bauman DR et al (2006) Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors. Mol Cell Endocrinol 248: 182-191.
19. Suzuki T, Miki Y, Moriya T et al (2007) 5Alpha-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production. Int J Cancer 120: 285-291.
20. Ishibashi H, Suzuki T, Suzuki S et al (2005) Progesterone receptor in non-small cell lung cancer-a potent prognostic factor and possible target for endocrine therapy. Cancer Res 65: 6450-6458.
21. Greenspan FS, Strewler GJ (1997) Basic & clinical endocrinology. Appleton Lange, Stamford.
22. Chetrite GS, Cortes-Prieto J, Philippe JC, Wright F, Pasqualini JR (2000) Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues. J Steroid Biochem Mol Biol 72: 23-27.
23. Nirmul D, Pegoraro RJ, Jialal I, Naidoo C, Joubert SM (1983) The sex hormone profile of male patients with breast cancer. Br J Cancer 48: 423-427.
24. Suzuki T, Miki Y, Nakamura Y, Ito K, Sasano H (2011) Steroid sulfatase and estrogen sulfotransferase in human carcinomas. Mol Cell Endocrinol 340: 148-153.
25. Ellis MJ, Miller WR, Tao Y et al (2009) Aromatase expression and outcomes in the P024 neoadjuvant endocrine therapy trial. Breast Cancer Res Treat 116: 371-378.
26. Geisler J, Suzuki T, Helle H et al (2010) Breast cancer aromatase expression evaluated by the novel antibody 677: correlations to intra-tumor estrogen levels and hormone receptor status. J Steroid Biochem Mol Biol 118: 237-241.
27. Poutanen M, Isomaa V, Lehto VP, Vihko R (1992) Immunological analysis of 17 beta-hydroxysteroid dehydrogenase in benign and malignant human breast tissue. Int J Cancer 50: 386-390.
28. Suzuki T, Moriya T, Ariga N, Kaneko C, Kanazawa M, Sasano H (2000) 17Beta-hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters. Br J Cancer 82: 518-523.
29. Yamamoto Y, Yamashita J, Toi M et al (2003) Immunohistochemical analysis of estrone sulfatase and aromatase in human breast cancer tissues. Oncol Rep 10: 791-796.
30. Tsunoda Y, Shimizu Y, Tsunoda A, Takimoto M, Sakamoto MA, Kusano M (2006) Steroid sulfatase in breast carcinoma and change of serum estrogens levels after operation. Acta Oncol 45: 584-589.
31. Sonne-Hansen K, Lykkesfeldt AE (2005) Endogenous aromatization of testosterone results in growth stimulation of the human MCF-7 breast cancer cell line. J Steroid Biochem Mol Biol 93: 25-34.
32. Korde LA, Zujewski JA, Kamin L et al (2010) Multidisciplinary meeting on male breast cancer: summary and research recommendations. J Clin Oncol 28: 2114-2122.
33. Gustafsson JA (2006) ERbeta scientific visions translate to clinical uses. Climacteric 9: 156-160.
34. Williams C, Edvardsson K, Lewandowski SA, Ström A, Gustafsson JA (2008) A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells. Oncogene 27: 1019-1032.
35. Nakopoulou L, Lazaris AC, Panayotopoulou EG et al (2004) The favourable prognostic value of oestrogen receptor beta immunohistochemical expression in breast cancer. J Clin Pathol 57: 523-528.
36. Honma N, Horii R, Iwase T et al (2005) Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy. J Clin Oncol 26: 3727-3734.
37. Weber-Chappuis K, Bieri-Burger S, Hurlimann J (1996) Comparison of prognostic markers detected by immunohistochemistry in male and female breast carcinomas. Eur J Cancer 32A: 1686-1692.
38. Johansson I, Nilsson C, Berglund P et al (2012) Gene expression profiling of primary male breast cancers reveals two unique subgroups and identifies N-acetyltransferase-1 (NAT1) as a novel prognostic biomarker. Breast Cancer Res 14: R31.
39. Chen Y, Olopade OI (2008) MYC in breast tumor progression. Expert Rev Anticancer Ther 8: 1689-1698.
40. Suzuki T, Moriya T, Sugawara A, Ariga N, Takabayashi H, Sasano H (2001) Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism. Breast Cancer Res Treat 65: 31-40.
41. Gaben AM, Sabbah M, Redeuilh G, Bedin M, Mester J (2012) Ligand-free estrogen receptor activity complements IGF1R to induce the proliferation of the MCF-7 breast cancer cells. BMC Cancer 12: 291.
42. Ma XJ, Wang Z, Ryan PD et al (2004) A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell 5: 607-616.
43. Wang Z, Dahiya S, Provencher H et al (2007) The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer. Clin Cancer Res 13: 6327-6334.
44. Guérin M, Sheng ZM, Andrieu N, Riou G (1990) Strong association between c-myb and oestrogen-receptor expression in human breast cancer. Oncogene 5: 131-135.
45. Cavaillès V, Dauvois S, L'Horset F et al (1995) Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J 14: 3741-3751.
46. Augereau P, Badia E, Balaguer P et al (2006) Negative regulation of hormone signaling by RIP140. J Steroid Biochem Mol Biol 102: 51-59.
47. Creekmore AL, Walt KA, Schultz-Norton JR et al (2008) The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression. Mol Cell Endocrinol 291: 79-86.
48. Zhang TF, Yu SQ, Wang ZY (2007) RbAp46 inhibits estrogen-stimulated progression of neoplastigenic breast epithelial cells. Anticancer Res 27: 3205-3209.
49. Chen YH, Wu ZQ, Zhao YL et al (2012) FHL2 inhibits the Id3-promoted proliferation and invasive growth of human MCF-7 breast cancer cells. Chin Med J Engl 125: 2329-2333.
50. Gupta GP, Perk J, Acharyya S et al (2007) ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc Natl Acad Sci U S A 104: 19506-19511.
51. Busser B, Sancey L, Brambilla E, Coll JL, Hurbin A (2011) The multiple roles of amphiregulin in human cancer. Biochim Biophys Acta 1816: 119-131.
52. Sengupta S, Sharma CG, Jordan VC (2010) Estrogen regulation of X-box binding protein-1 and its role in estrogen induced growth of breast and endometrial cancer cells. Horm Mol Biol Clin Investig 2: 235-243.
53. Oh DS, Troester MA, Usary J et al (2006) Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers. J Clin Oncol 24: 1656-1664.