Rebuild, restore, reinnervate: Do human tissue engineered dermo-epidermal skin analogs attract host nerve fibers for innervation?

Pediatric Surgery International

Volumn 29, Issue 1, 2013, Pages 71-78

  Biedermann, Thomas ^a   Böttcher Haberzeth, Sophie ^a   Klar, Agnieszka S ^a   Pontiggia, Luca ^a   Schiestl, Clemens ^a   Meuli Simmen, Claudia ^b   Reichmann, Ernst ^a   Meuli, Martin ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b Kantonsspital Aarau   (Switzerland)

Author keywords

Human skin analog; Innervation; Nerve fibers; Rat model

Indexed keywords

CELL TYPE; CONFERENCE PAPER; CONTROLLED STUDY; EPIDERMIS CELL; FIBROBLAST; HISTOPATHOLOGY; HOST; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; INNERVATION; KERATINOCYTE; MELANOCYTE; NERVE FIBER; POLYMERIZATION; PRIORITY JOURNAL; REINNERVATION; SKIN BIOPSY; TISSUE ENGINEERING; VASCULARIZATION;

ANIMALS; CELLS, CULTURED; DERMIS; EPIDERMIS; HUMANS; NERVE FIBERS; RATS; SKIN; SKIN, ARTIFICIAL; TISSUE ENGINEERING;

EID: 84872281656     PISSN: 01790358     EISSN: 14379813     Source Type: Journal    
DOI: 10.1007/s00383-012-3208-1     Document Type: Conference Paper

References (19)

1. Hermanson A, Dalsgaard CJ (1987) Sensory reinnervation and sensibility in skin transplants. Med Biol 65(1):49-52
2. Altun V, Hakvoort TE, van Zuijlen PP, van der Kwast TH, Prens EP (2001) Nerve outgrowth and neuropeptide expression during the remodeling of human burn wound scars. A 7-month follow-up study of 22 patients. Burns 27(7):717-722
3. Ward RS, Tucket RP, English KB, Johansson O, Saffle JR (2003) Substance P axons and sensory threshold increase in burn-graft human skin. J Surg Res 118:154-160
4. Nedelec B, Hou Q, Sohbi I, Choiniüre M, Beauregard G, Dykes RW (2005) Sensory perception and neuroanatomical structures in normal and grafted skin of burn survivors. Burns 31:817-830
5. Anderson JR, Zorbas JS, Phillips JK, Harrison JL, Dawson LF, Bolt SE, Rea SM, Klatte JE, Paus R, Zhu B, Giles NL, Drummond PD, Wood FM, Fear MW (2010) Systemic decreases in cutaneous innervation after burn injury. J Invest Dermatol 130:1948-1951
6. Anderson JR, Fear MW, Phillips JK, Dawson LF, Wallace H, Wood FM, Rea SM (2011) A preliminary investigation of the reinnervation and return of sensory function in burn patients treated with INTEGRA®. Burns 37(7):1101-1108
7. Pontiggia L, Biedermann T, Meuli M, Widmer D, Böttcher-Haberzeth S, Schiestl C, Schneider J, Braziulis E, Montaño I, Meuli-Simmen C, Reichmann E (2009) Markers to evaluate the quality and self-renewing potential of engineered human skin substitutes in vitro and after transplantation. J Invest Dermatol 129(2):480-490
8. Biedermann T, Pontiggia L, Böttcher-Haberzeth S, Tharakan S, Braziulis E, Schiestl C, Meuli M, Reichmann E (2010) Human eccrine sweat gland cells can reconstitute a stratified epidermis. J Invest Dermatol 130(8):1996-2009
9. Kiowski G, Biedermann T, Widmer DS, Civenni G, Burger C, Dummer R, Sommer L, Reichmann E (2012) Engineering melanoma progression in a humanized environment in vivo. J Invest Dermatol 132(1):144-153
10. Montaño I, Schiestl C, Schneider J, Pontiggia L, Luginbühl JF, Böttcher-Haberzeth S, Biedermann T, Braziulis E, Meuli M, Reichmann E (2010) Formation of human capillaries in vitro: the engineering of pre-vascularized matrices. Tissue Eng Part A 16(1):269-282
11. Böttcher-Haberzeth S, Biedermann T, Pontiggia L, Braziulis E, Schiestl C, Hendriks B, Eichhoff OM, Widmer DS, Meuli-Simmen C, Meuli M, Reichmann E (2012) Human eccrine sweat gland cells turn into melanin-uptaking keratinocytes in stratifying dermo-epidermal skin substitutes. J Invest Dermatol. doi: 10.1038/jid.2012.290
12. Schneider J, Biedermann T, Widmer D, Montano I, Meuli M, Reichmann E, Schiestl C (2009) Matriderm versus Integra: a comparative experimental study. Burns 35(1):51-57
13. Böttcher-Haberzeth S, Biedermann T, Schiestl C, Hartmann-Fritsch F, Schneider J, Reichmann E, Meuli M (2012) Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats. Pediatr Surg Int 28(2):171-177
14. Wendelschafer-Crabb G, Kennedy WR, Walk D (2006) Morphological features of nerves in skin biopsies. J Neurol Sci 242(1-2):15-21
15. Yen LD, Bennett GJ, Ribeiro-da-Silva A (2006) Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury. J Comp Neurol 495(6):679-690
16. Taylor AM, Peleshok JC, Ribeiro-da-Silva A (2009) Distribution of P2X(3)-immunoreactive fibers in hairy and glabrous skin of the rat. J Comp Neurol 514(6):555-566
17. Martínez-Martínez E, Toscano-Márquez B, Gutiérrez-Ospina G (2011) Long-term effects of neonatal capsaicin treatment on intraepidermal nerve fibers and keratinocyte proliferation in rat glabrous skin. Anat Rec 294(1):173-184
18. Lambrechts D, Carmeliet P (2006) VEGF at the neurovascular interface: therapeutic implications for motor neuron disease. Biochim Biophys Acta 1762(11-12):1109-1121
19. Carmeliet P, Tessier-Lavigne M (2005) Common mechanisms of nerve and blood vessel wiring. Nature 436(7048):193-200