Serum profile of T helper 1 and T helper 2 cytokines in hepatitis C virus infected patients

Hepatitis Monthly

Volumn 12, Issue 12, 2012, Pages

  Sofian, Masoomeh ^a   Aghakhani, Arezoo ^b   Farazi, Ali Asghar ^a   Banifazl, Mohammad ^c   Eslamifar, Ali ^b   Rashidi, Niloofar ^b   Khadem Sadegh, Akbar ^b   Ramezani, Amitis ^b  

^a ARAK UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

^c Iranian Liver Charity   (Iran)

Author keywords

Cytokines; Hepatitis C; Th1 Cells; Th2 Cells

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; PEGINTERFERON; RIBAVIRIN;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; QUESTIONNAIRE; TH1 CELL; TH2 CELL; VIRUS LOAD;

EID: 84872281401     PISSN: 1735143X     EISSN: 17353408     Source Type: Journal    
DOI: 10.5812/hepatmon.6156     Document Type: Article

References (24)

1. Chen TY, Hsieh YS, Wu TT, Yang SF, Wu CJ, Tsay GJ, et al. Impact of serum levels and gene polymorphism of cytokines on chronic hepatitis C infection. Transl Res. 2007;150(2):116-21.
2. Barrett S, Goh J, Coughlan B, Ryan E, Stewart S, Cockram A, et al. The natural course of hepatitis C virus infection after 22 years in a unique homogenous cohort: spontaneous viral clearance and chronic HCV infection. Gut. 2001;49(3):423-30.
3. Zucker SD. Whomsoever ignores the natural history of the hepatitis C virus is doomed to treat it. Gastroenterology. 2002;122(2):578-9.
4. Powell EE, Edwards-Smith CJ, Hay JL, Clouston AD, Crawford DH, Shorthouse C, et al. Host genetic factors influence disease progression in chronic hepatitis C. Hepatology. 2000;31(4):828-33.
5. Tsutsumi T, Suzuki T, Shimoike T, Suzuki R, Moriya K, Shintani Y, et al. Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity. Hepatology. 2002;35(4):937-46.
6. Koziel MJ, Dudley D, Afdhal N, Grakoui A, Rice CM, Choo QL, et al. HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release. J Clin Invest. 1995;96(5):2311-21.
7. Fishman MA, Perelson AS. Th1/Th2 cross regulation. J Theor Biol. 1994;170(1):25-56.
8. Pernis A, Gupta S, Gollob KJ, Garfein E, Coffman RL, Schindler C, et al. Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells. Science. 1995;269(5221):245-7.
9. Sher A, Gazzinelli RT, Oswald IP, Clerici M, Kullberg M, Pearce EJ, et al. Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol Rev. 1992;127:183-204.
10. Abayli B, Canataroglu A, Akkiz H. Serum profile of T helper 1 and T helper 2 cytokines in patients with chronic hepatitis C virus infection. Turk J Gastroenterol. 2003;14(1):7-11.
11. Cacciarelli TV, Martinez OM, Gish RG, Villanueva JC, Krams SM. Immunoregulatory cytokines in chronic hepatitis C virus infection: pre-and posttreatment with interferon alfa. Hepatology. 1996;24(1):6-9.
12. Fan XG, Liu WE, Li CZ, Wang ZC, Luo LX, Tan DM, et al. Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection. Mediators Inflamm. 1998;7(4):295-7.
13. Osna N, Silonova G, Vilgert N, Hagina E, Kuse V, Giedraitis V, et al. Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood. Scand J Clin Lab Invest. 1997;57(8):703-10.
14. Shapiro S, Gershtein V, Elias N, Zuckerman E, Salman N, Lahat N. mRNA cytokine profile in peripheral blood cells from chronic hepatitis C virus (HCV)-infected patients: effects of interferon-alpha (IFN-alpha) treatment. Clin Exp Immunol. 1998;114(1):55-60.
15. Cribier B, Schmitt C, Rey D, Lang JM, Kirn A, Stoll-Keller F. Production of cytokines in patients infected by hepatitis C virus. J Med Virol. 1998;55(2):89-91.
16. Lucey DR, Clerici M, Shearer GM. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin Microbiol Rev. 1996;9(4):532-62.
17. Malaguarnera M, Di Fazio I, Laurino A, Pistone G, Restuccia S, Trovato BA. Decrease of interferon gamma serum levels in patients with chronic hepatitis C. Biomed Pharmacother. 1997;51(9):391-6.
18. Dogra G, Chakravarti A, Kar P, Chawla YK. Polymorphism of tumor necrosis factor-alpha and interleukin-10 gene promoter region in chronic hepatitis C virus patients and their effect on pegylated interferon-alpha therapy response. Hum Immunol. 2011;72(10):935-9.
19. Atsukawa M, Nakatsuka K, Kobayashi T, Shimizu M, Tamura H, Harimoto H, et al. Ribavirin downmodulates inducible costimulator on CD4+ T cells and their interleukin-10 secretion to assist in hepatitis C virus clearance. J Gastroenterol Hepatol. 2012;27(4):823-31.
20. Ferrari C, Urbani S, Penna A, Cavalli A, Valli A, Lamonaca V, et al. Immunopathogenesis of hepatitis C virus infection. J Hepatol. 1999;31 (Suppl 1):31-8.
21. Reiser M, Marousis CG, Nelson DR, Lauer G, Gonzalez-Peralta RP, Davis GL, et al. Serum interleukin 4 and interleukin 10 levels in patients with chronic hepatitis C virus infection. J Hepatol. 1997;26(3):471-8.
22. Napoli J, Bishop GA, McGuiness P, al e. Increased intrahepatic TH1 cytokine mRNA levels correlate with tissue damage in chronic hepatitis C. Hepatology. 1995;22:222.
23. Fan X, Liu W, Li C. [Determination of serum cytokines in individuals with HCV infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2000;14(2):145-7.
24. Inglot M, Gladysz A, Rymer W, Molin I, Zalewska M, Machaj A. [Cytokine assessment in untreated hepatitis C virus infected patients and during interferon alpha +ribavirine therapy]. Wiad Lek. 2008;61(1-3):13-8.