Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 57, Issue 8, 1997, Pages 703-710

  Osna, N ^a   Silonova, G ^b   Vilgert, N ^a   Hagina, E ^a   Kuse, V ^b   Giedraitis, V ^c   Zvirbliene, A ^c   Mauricas, M ^c   Sochnev, A ^a  

^a RIGA STRADINS UNIVERSITY   (Latvia)

^b Tuberculosis and Lung Disease Clinic Riga   (Latvia)

^c VILNIUS UNIVERSITY   (Lithuania)

Author keywords

Chronic hepatitis C; Interferon gamma; Interleukin 10; Interleukin 12; Interleukin 4

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4;

ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; HELPER CELL; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; INFECTION RISK; PATHOGENESIS; PRIORITY JOURNAL; VIRUS RESISTANCE;

HEPATITIS C VIRUS;

EID: 0031463331     PISSN: 00365513     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365519709105232     Document Type: Article

References (21)

1. Meyer zum Buschenfelde KH. Immunopathology of chronic liver diseases. Verh Dtsch Ges Pathol 1995; 79: 186-97.
2. Wejstal R. Immune-mediated liver damage in chronic hepatitis C Scand J Gastroent 1995, 30: 609-13.
3. Schlaak F, Lohr H, Gallati H, Meyer zum Buschenfelde KH, Fleischer B. Analysis of in vitro cytokine production by liver-infiltrating T cells of patients with autoimmune hepatitis. Clin Exp Immunol 1993; 94: 168-73.
4. Koziel MJ, Dudley D, Afdhal N, Grakoui A, Rice CM, Choo QL, Houghton M, Walker BD. HLA class 1-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release. J Clin Invest 1995; 96: 2311-21.
5. Lohr HF, Schlaak JF, Kollmannsperger S, Dienes HP, Meyer zum Buschenfelde KH, Gerken G. Liver-infiltrating and circulating CD4+ T cells in chronic hepatitis C: immunodominant epitopes, HLA-restriction and functional significance. Liver 1996; 16: 174-84.
6. Fukuda K, Nishiguchi S, Kuroki T, Mormoto H, Sakuraj M, Otani S, Matsuhisa H, Kobajashi K. Nonisototic in situ detection of hepatitis C virus in peripheral blood mononuclear cells. J Hepatol 1995; 23 Suppl 1: 94.
7. Mihm S, Hartmann H, Ramadori G. Detection of antigenomic HCV RNA associated with peripheral blood polymorphonuclear granulocytes in patients with chronic hepatitis C J Hepatol, 1995; 23 Suppl 1: 88.
8. Moldvay J, Deny P, Pol S, Brechot C, Lamas E. In situ hybridization for the detection of hepatitis C virus RNA in mononuclear cells of peripheral blood from infected patients. Orv Hetil 1995; 136: 2267-71.
9. Booth JCL, Walters J, Brown JL, Thomas HC. The cellular tropism of HCV J Hepatol 1995; 23 Suppl 1: 104.
10. Chang TT, Young KC, Yang YY, Lei HJ, Wu HL. Hepatitis C virus RNA in peripheral blood mononuclear cells: comparing acute and chronic hepatitis C virus infection. Hepatology 1996; 23: 977-81.
11. Kusaka S, Okusa A, Araki A, Fujiki K, Takashimuzu I, Okayasu I, Jamomoto N Sato Ch. Prediction of relapses after interferon-alpha therapy by hepatitis C virus RNA in peripheral blood mononuclear cell. J Med Virology 1995; 46: 265-8.
12. Taliani G, Badolato M, Lecce R, Poliandri G, Bazzi A, Duca F, Pasquazzi C, Clementi C, Furlan C, De Bac C. Hepatitis C Virus RNA in peripheral blood mononuclear cells: relation with response to interferon treatment. J Med Virology 1995; 47: 16-22.
13. Osna N, Duk A, Sochnev A. Interferon gamma production in whole peripheral blood culture in acute hepatitis B Scand J Clin Lab Invest 1996; 56: 145-50.
14. Quiroga JA, Martin J, Pardo M, Carreno V. Serum levels of soluble immune factors and pathogenesis of chronic hepatitis C, and their relation to therapeutic response to interferon-alpha. Digest Dis Sci 1994; 39: 2485-96.
15. Jirillo E, Greco B, Caradonna L, Satalino R, Pugliese V, Cozzolongo R, et al. Evaluation of cellular immune response and soluble mediators in patients with chronic hepatitis C (cHCV) infection. Immunopharmacol Immunotoxicol 1995; 17: 347-64.
16. Lechmann M, Irrgang B, Bar S, Woitas R, Leifeld L, Ihlenfeld HG, et al. Antigen specific CD 30 induction on CD4+ memory T lymphocytes in patients with chronic hepatitis C and healthy anti- HCV seropositives. J Hepatol 1996; 25 Suppl 1: 79.
17. Lohr HF, Schlaak JH, Gerken G, Fleischer B, Dienes H-P, Meyer zum Buschenfelde KH. Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T-lymphocytes from patients with chronic hepatitis of different etiology. Liver 1994; 14: 161-6.
18. Tsai S-T, Liaw Y-F, Chen M-H, Huang C-Y, Kuo GC. Detection of type 2-like T-helper cells in hepatitis C virus infection: implication for chronicity. Hepatology 1997; 25: 449-58.
19. Lechman M, Langhans B, Bar S, Woitas R, Leifeld HG, Ihlenfeldt HG, et al. Deficient secretion of Th1 cytokines in patients with chronic hepatitis C J Hepatology 1997; 26 Suppl 1: 115.
20. Gately MK, Magram I, Wu C, McIntyre K, Stern A, Presky D, Bradshaw D, Lad N, Gubler U. Studies on the IL-12R, and IL-12R antagonists: evidence that IL-12 is a critical mediator of both normal and pathologic Th1 dependent immune responses. Pathogenesis and immunotherapy of autoimmune diseases. Second Symposium, 25-27 October. Roche Milan, 1996: 47.
21. Trincheri G. Control of production of interleukin-12 and its alteration in disease. Pathogenesis and immunotherapy of autoimmune diseases. Second Symposium, 25-27 October. Roche Milan, 1996: 48.