Lead optimization of isocytosine-derived xanthine oxidase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 3, 2013, Pages 834-838

  Bajaj, Komal ^a   Burudkar, Sandeep ^a   Shah, Pranay ^a   Keche, Ashish ^a   Ghosh, Usha ^a   Tannu, Prashant ^a   Khanna, Smriti ^a   Srivastava, Ankita ^a   Deshmukh, Nitin J ^a   Dixit, Amol ^a   Ahire, Yogesh ^a   Damre, Anagha ^a   Nemmani, Kumar V S ^a   Kulkarni Almeida, Asha ^a   B Rao, Chandrika ^a   Sharma, Rajiv ^a   Sivaramakrishnan, H ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

Docking; Isocytosine; Pharmacokinetics; Structure activity relationship; Xanthine oxidase inhibitors

Indexed keywords

ALLOPURINOL; CYTOSINE; DOCKING PROTEIN; FEBUXOSTAT; ISOCYTOSINE; UNCLASSIFIED DRUG; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG HALF LIFE; IC 50; MOLECULAR DOCKING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CATALYTIC DOMAIN; CYTOSINE; ENZYME ACTIVATION; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MODELS, ANIMAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; XANTHINE OXIDASE;

EID: 84872280912     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.057     Document Type: Article

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