Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 3, 2013, Pages 744-749

  Dai, Dongcheng ^a   Burgeson, James R ^a   Gharaibeh, Dima N ^a   Moore, Amy L ^a   Larson, Ryan A ^a   Cerruti, Natasha R ^a   Amberg, Sean M ^a   Bolken, Tove C ^a   Hruby, Dennis E ^a  

^a SIGA Technologies Incorporated   (United States)

Author keywords

Antiviral; Arenavirus; Broad spectrum inhibitor; Entry inhibitor; Lassa fever; Lassa virus; SAR

Indexed keywords

ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; HEXYLRESORCINOL; RIBAVIRIN; ST 193; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARENAVIRUS INFECTION; ARTICLE; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENCY; DRUG SCREENING; EXPERIMENTAL GUINEA PIG; LASSA VIRUS; LOW DRUG DOSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS ENVELOPE; VIRUS LOAD;

ANIMALS; ANTIVIRAL AGENTS; ARENAVIRUS; BENZIMIDAZOLES; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; GUINEA PIGS; SMALL MOLECULE LIBRARIES;

ARENAVIRUS; CAVIA; LASSA VIRUS;

EID: 84872279263     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.095     Document Type: Article

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