Antithrombin levels and the risk of a first episode of venous thromboembolism. A case-control study

Thrombosis and Haemostasis

Volumn 109, Issue 1, 2013, Pages 167-169

  Di Minno, Matteo Nicola Dario ^a   Dentali, Francesco ^b   Veglia, Fabrizio ^c   Russolillo, Anna ^a   Tremoli, Elena ^c,d   Ageno, Walter ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

^c CENTRO CARDIOLOGICO MONZINO   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; CARDIOLIPIN ANTIBODY; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOLIPID ANTIBODY;

ADULT; ANTITHROMBIN DEFICIENCY; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; FEMALE; HUMAN; HYPERTENSION; INTERVIEW; LETTER; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; VENOUS THROMBOEMBOLISM;

ADULT; AGE OF ONSET; ANTITHROMBIN III; ANTITHROMBIN III DEFICIENCY; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; HUMANS; ITALY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PERFUSION IMAGING; PREVALENCE; RISK ASSESSMENT; RISK FACTORS; TOMOGRAPHY, SPIRAL COMPUTED; ULTRASONOGRAPHY; VENOUS THROMBOEMBOLISM;

EID: 84872255658     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-09-0663     Document Type: Letter

References (15)

1. De Stefano V, Finazzi G, Mannucci PM. Inherited thrombophilia: pathogenesis, clinical syndromes, and management. Blood 1996; 87: 3531-3544.
2. Lane DA, Bayston T, Olds RJ, et al. Antithrombin mutation database: 2nd (1997) update. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Thromb Haemost 1997; 77: 197-211.
3. Simioni P, Sanson BJ, Prandoni P, et al. Incidence of venous thromboembolism in families with inherited thrombophilia. Thromb Haemost 1999; 81: 198-202.
4. Sanson BJ, Simioni P, Tormene D, et al. The incidence of venous thromboembolism in asymptomatic carriers of a deficiency of antithrombin, protein C, or protein S: a prospective cohort study. Blood 1999; 94: 3702-3706.
5. De Stefano V, Leone G, Mastrangelo S, et al. Clinical manifestations and management of inherited thrombophilia: retrospective analysis and followup after diagnosis of 238 patients with congenital deficiency of antithrombin III, protein C, protein S. Thromb Haemost 1994; 72: 352-358.
6. Martinelli I, Mannucci PM, De Stefano V, Taioli E, Rossi V, Crosti F, et al. Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families. Blood 1998; 92: 2353-2358.
7. De Stefano V. Inherited thrombophilia and lifetime risk of venous thromboembolism: is the burden reducible? J Thromb Haemost 2004; 2: 1522-1525.
8. Vossen CY, Conard J, Fontcuberta J, et al. Familial thrombophilia and lifetime risk of venous thrombosis. J Thromb Haemost 2004; 2: 1526-1532.
9. Vossen CY, Conard J, Fontcuberta J, et al. Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). J Thromb Haemost 2005; 3: 459-464.
10. Dentali F, Gianni M. VTE recurrence in patients with inherited deficiencies of natural anticoagulants. Thromb Haemost 2009; 101: 5-6.
11. Di Minno MN, Tufano A, Guida A, et al. Abnormally high prevalence of major components of the metabolic syndrome in subjects with early-onset idiopathic venous thromboembolism. Thromb Res 2011; 127: 193-197.
12. Heijboer H, Brandjes DPM, Buller HR, et al. Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis. N Engl J Med (year??); 323: 1512-1516.
13. Bucciarelli P, Passamonti SM, Biguzzi E, et al. Low borderline plasma levels of antithrombin, protein C and protein S are risk factors for venous thromboembolism. J Thromb Haemost 2012; 10: 1783-1791.
14. Castaldo G, Cerbone AM, Guida A, et al. Molecular analysis and genotype-phenotype correlation in patients with Antithrombin deficiency from Southern Italy. Thromb Haemost 2012; 107: 673-680.
15. Antón AI, Teruel R, Corral J, et al. Functional consequences of the prothrombotic SERPINC1 rs2227589 polymorphism on antithrombin levels. Haematologica 2009; 94: 589-592.