Functional Innervation of Guinea-Pig Bladder Interstitial Cells of Cajal Subtypes: Neurogenic Stimulation Evokes In Situ Calcium Transients

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Gray, Susannah M ^a   McGeown, J Graham ^a   McMurray, Gordon ^b   McCloskey, Karen D ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; ARTICLE; BLADDER INNERVATION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL COMMUNICATION; CELL FUNCTION; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; ELECTROSTIMULATION; GUINEA PIG; INTERSTITIAL CELL OF CAJAL; MALE; NONHUMAN; SMOOTH MUSCLE FIBER;

ANIMALS; CALCIUM; CALCIUM SIGNALING; ELECTRIC STIMULATION; GUINEA PIGS; INTERSTITIAL CELLS OF CAJAL; MALE; MUCOUS MEMBRANE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; URINARY BLADDER;

CAVIA;

EID: 84872253645     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053423     Document Type: Article

References (25)

1. Johnston L, Cunningham RM, Young JS, Fry CH, McMurray G, et al. (2012) Altered distribution of interstitial cells and innervation in the rat urinary bladder following spinal cord injury. J Cell Mol Med. 16: 1533-43.
2. Davidson RA, McCloskey KD, (2005) Morphology and localization of interstitial cells in the guinea pig bladder: structural relationships with smooth muscle and neurons. J Urol 173: 1385-1390.
3. Sui GP, Rothery S, Dupont E, Fry CH, Severs NJ, (2002) Gap junctions and connexin expression in human suburothelial interstitial cells. BJU Int. 90: 118-129.
4. Johnston L, Woolsey S, Cunningham RM, O'Kane H, Duggan B, et al. (2010) Morphological expression of KIT positive interstitial cells of Cajal in human bladder. J Urol 184: 370-377.
5. McCloskey KD, Gurney AM, (2002) Kit positive cells in the guinea pig bladder. J Urol. 168: 832-836.
6. Wu C, Sui GP, Fry CH, (2004) Purinergic regulation of guinea pig suburothelial myofibroblasts. J Physiol. 559: 231-243.
7. Johnston L, Carson C, Lyons AD, Davidson RA, McCloskey KD, (2008) Cholinergic-induced Ca2+ signaling in interstitial cells of Cajal from the guinea pig bladder. Am J Physiol Renal Physiol. 294: F645-655.
8. Burnstock G, (1977) Autonomic neuroeffector junctions-reflex vasodilatation of the skin. J Invest Dermatol 69: 47-57.
9. Burnstock G, (1986) Autonomic neuromuscular junctions: current developments and future directions. J Anat 146: 1-30.
10. Ferguson DR, Kennedy I, Burton TJ, (1997) ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes-a possible sensory mechanism? J Physiol 505: 503-511.
11. Andersson KE, Arner A, (2004) Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev 84: 935-986.
12. Ward SM, Sanders KM, Hirst GD (2004) Role of interstitial cells of Cajal in neural control of gastrointestinal smooth muscles. Neurogastroenterol Motil. Suppl 1: 112-117.
13. Kubota Y, Hashitani H, Shirasawa N, Kojima Y, Sasaki S, et al. (2008) Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction. Neurourol Urodyn 27: 330-340.
14. Wiseman OJ, Fowler CJ, Landon DN, (2003) The role of the human bladder lamina propria myofibroblast. BJU Int 91: 89-93.
15. Dixon JS, Gosling JA, (1983) Histology and fine structure of the muscularis mucosae of the human urinary bladder. J Anat 136: 265-271.
16. Heppner TJ, Layne JJ, Pearson JM, Sarkissian H, Nelson MT, (2011) Unique properties of muscularis mucosae smooth muscle in guinea pig urinary bladder. Am J Physiol Regul Integr Comp Physiol301: R351-362.
17. Hashitani H, Takano H, Fujita K, Mitsui R, Suzuki H, (2011) Functional properties of suburothelial microvessels in the rat bladder. J Urol 185: 2382-2391.
18. Cunningham RM, Larkin P, McCloskey KD, (2011) Ultrastructural properties of interstitial cells of Cajal in the Guinea pig bladder. J Urol 85: 1123-1131.
19. Fry CH, Young JS, Jabr RI, McCarthy C, Ikeda Y, et al. (2012) Modulation of spontaneous activity in the overactive bladder- the role of P2Y agonists. Am J Physiol Renal Physiol [Epub ahead of print].
20. Sui GP, Wu C, Roosen A, Ikeda Y, Kanai AJ, et al. (2008) Modulation of bladder myofibroblast activity: implications for bladder function. Am J Physiol Renal Physiol 95: F688-697.
21. Hashitani H, Brading AF, (2003) Electrical properties of detrusor smooth muscles from the pig and human urinary bladder. Br J Pharmacol 140: 146-158.
22. Hashitani H, Brading AF, Suzuki H, (2004) Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br J Pharmacol 141: 183-193.
23. Young JS, Meng E, Cunnane TC, Brain KL, (2008) Spontaneous purinergic neurotransmission in the mouse urinary bladder. J Physiol. 586: 5743-5755.
24. Zagorodnyuk VP, Gregory S, Costa M, Brookes SJ, Tramontana M, et al. (2009) Spontaneous release of acetylcholine from autonomic nerves in the bladder. Br J Pharmacol (157) (): 607-19.
25. Hashitani H, Yanai Y, Suzuki H, (2004) Role of interstitial cells and gap junctions in the transmission of spontaneous Ca2+ signals in detrusor smooth muscles of the guinea-pig urinary bladder. J Physiol 559: 567-581.