Cochrane Review: Osmotic and stimulant laxatives for the management of childhood constipation

Evidence-Based Child Health

Volumn 8, Issue 1, 2013, Pages 57-109

  Gordon, Morris ^a,b   Naidoo, Khimara ^c   Akobeng, Anthony K ^a   Thomas, Adrian G ^a  

^a ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF SALFORD   (United Kingdom)

^c GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Adolescent; Child; Child, Preschool; Constipation *drug therapy ; Defecation drug effects; physiology ; Dietary Fiber adverse effects; therapeutic use ; Humans; Infant; Lactulose adverse effects; therapeutic use ; Laxatives adverse effects; *therapeutic use ; Magnesium Hydroxide adverse effects; therapeutic use ; Mineral Oil adverse effects; therapeutic use ; Osmosis; Polyethylene Glycols adverse effects; therapeutic use ; Randomized Controlled Trials as Topic; Sugar Alcohols adverse effects; therapeutic use

Indexed keywords

LACTULOSE; LAXATIVE; MACROGOL DERIVATIVE; MINERAL OIL; SENNA EXTRACT; SENNOSIDE A&B;

ADOLESCENT; CHILD; COMPARATIVE STUDY; CONSTIPATION; CONSTIPATION [*DRUG THERAPY]; DEFECATION; DEFECATION [DRUG EFFECTS; PHYSIOLOGY]; DIETARY FIBER [ADVERSE EFFECTS; THERAPEUTIC USE]; DRUG EFFECT; FEMALE; HUMAN; INFANT; LACTULOSE [ADVERSE EFFECTS; THERAPEUTIC USE]; LAXATIVES [ADVERSE EFFECTS; *THERAPEUTIC USE]; MAGNESIUM HYDROXIDE [ADVERSE EFFECTS; THERAPEUTIC USE]; MALE; META ANALYSIS; MINERAL OIL [ADVERSE EFFECTS; THERAPEUTIC USE]; NEWBORN; OSMOSIS; POLYETHYLENE GLYCOLS [ADVERSE EFFECTS; THERAPEUTIC USE]; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SUGAR ALCOHOLS [ADVERSE EFFECTS; THERAPEUTIC USE]; TREATMENT OUTCOME;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CONSTIPATION [*DRUG THERAPY]; DEFECATION [DRUG EFFECTS; PHYSIOLOGY]; DIETARY FIBER [ADVERSE EFFECTS; THERAPEUTIC USE]; HUMANS; INFANT; LACTULOSE [ADVERSE EFFECTS; THERAPEUTIC USE]; LAXATIVES [ADVERSE EFFECTS; *THERAPEUTIC USE]; MAGNESIUM HYDROXIDE [ADVERSE EFFECTS; THERAPEUTIC USE]; MINERAL OIL [ADVERSE EFFECTS; THERAPEUTIC USE]; OSMOSIS; POLYETHYLENE GLYCOLS [ADVERSE EFFECTS; THERAPEUTIC USE]; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SUGAR ALCOHOLS [ADVERSE EFFECTS; THERAPEUTIC USE];

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CONSTIPATION; DEFECATION; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LACTULOSE; LAXATIVES; MALE; MINERAL OIL; POLYETHYLENE GLYCOLS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SENNA EXTRACT; TREATMENT OUTCOME;

EID: 84872234534     PISSN: None     EISSN: 15576272     Source Type: Journal    
DOI: 10.1002/ebch.1893     Document Type: Review

References (111)

1. References to studies included in this review
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5. Candy DC, Edwards D, Geraint M. Treatment of faecal impaction with polyethylene glycol plus electrolytes (PGE + E) followed by a double-blind comparison of PEG + E versus lactulose as maintenance therapy. Journal of Pediatric Gastroenterology and Nutrition 2006;43(1):65-70.
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7. Dupont C, Leluyer B, Maamri N, Morali A, Joye J, Fiorini J, et al.Double-blind randomized evaluation of clinical and biological tolerance of polyethylene glycol 4000 versus lactulose in constipated children. Journal of Pediatric Gastroenterology and Nutrition 2005;41(5):625-33.
8. Farahmand 2007 {published data only}
9. Farahmand F. A randomised trial of liquid paraffin versus lactulose in the treatment of chronic functional constipation in children. Acta Medica Iranica 2007;45:183-8.
10. Gomes 2011 {published data only}
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38. References to studies excluded from this review
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49. Hardikar 2007 {published data only}
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55. Kinservik 2004 {published data only}
56. Kinservik MA, Friedhoff MM. The efficacy and safety of polyethylene glycol 3350 in the treatment of constipation in children. Pediatric Nursing 2004;30(3):232-7.
57. Loening-Baucke 2002 {published data only}
58. Loening-Baucke V. Polyethylene glycol without electrolytes for children with constipation and encopresis. Journal of Pediatric Gastroenterology and Nutrition 2002;34(4):372-7.
59. Loening-Baucke 2004 {published data only}
60. Loening-Baucke V, Krishna R, Pashankar DS. Polyethylene glycol 3350 without electrolytes for the treatment of functional constipation in infants and toddlers. Journal of Pediatric Gastroenterology and Nutrition 2004;39(5):536-9.
61. Miller 2012 {published data only}
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64. Moulies A. The treatment of constipation in the child: results obtained with a new medicinal agent prepared from the pericarp of senna follicles. Gazette Medicale de France 1961;68:239-44.
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