A randomized trial of enema versus polyethylene glycol 3350 for fecal disimpaction in children presenting to an emergency department

Pediatric Emergency Care

Volumn 28, Issue 2, 2012, Pages 115-119

  Miller, Melissa K ^a   Dowd, Mary Denise ^a   Friesen, Craig A ^a   Walsh Kelly, Christine M ^a  

^a CHILDREN S MERCY HOSPITAL   (United States)

Author keywords

constipation; enema; fecal impaction; randomized trial

Indexed keywords

ENEMA; MACROGOL 3350; MOLASSES;

ADOLESCENT; ARTICLE; CHILD; CONTROLLED STUDY; EMERGENCY WARD; FECES; FECES IMPACTION; FEMALE; FOLLOW UP; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MILK; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; THERAPY EFFECT; TREATMENT FAILURE;

ADMINISTRATION, ORAL; ADOLESCENT; CATHARTICS; CHILD; CHILD, PRESCHOOL; CONSTIPATION; EMERGENCIES; EMERGENCY SERVICE, HOSPITAL; ENEMA; FECAL IMPACTION; FECES; FEMALE; HUMANS; INFANT; LAXATIVES; MALE; MOLASSES; OSMOSIS; PATIENT READMISSION; POLYETHYLENE GLYCOLS; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84863398220     PISSN: 07495161     EISSN: 15351815     Source Type: Journal    
DOI: 10.1097/PEC.0b013e3182442c0a     Document Type: Article

References (25)

1. Drossman DA. ed. ROME II: The Functional Gastrointestinal Disorders. McLean, VA: Degnon Associates.
2. Ponreau D, Roblin N, Bird M, et al. The pediatric bowel management clinic: initial results of a multidisciplinary approach to functional constipation in children. J Pediatr Surg. 1997;32:843-848. (Pubitemid 27264042)
3. Reynolds SL, Jaffe DM. Children with abdominal pain: evaluation in the pediatric emergency department. Pediatr Emerg Care. 1990;6:8-12. (Pubitemid 20159874)
4. Miller M, Dowd MD, Fraker M. Emergency department management and short-term outcome of children with constipation. Pediatr Emerg Care. 2007;23:1-4. (Pubitemid 46115342)
5. Patel H, Law A, Gouin S. Predictive factors for short-term symptom persistence in children after emergency department evaluation for constipation. Arch Pediatr Adolesc Med. 2000;154:1204-1208.
6. Baker SS, Liptak GS, Colletti RB, et al. Constipation in infants and children: evaluation and treatment. J Pediatr Gastroenterol Nutr. 1999;29:612-626. (Pubitemid 30346350)
7. Borowitz SM, Cox DJ, Kovatchev B, et al. Treatment of constipation by primary care physicians: efficacy and predictors of outcome. Pediatrics. 2005;115:873-877.
8. Lewis AV, Hillmeier AC. Pediatric constipation: diagnosis and therapy. Pract Gastroenterol. 1989;13:31-39.
9. Gleghorn EE, Heyman MB, Rudolph CD. No-enema therapy for idiopathic constipation and encopresis. Clin Pediatr. 1991;30:669-672.
10. Bell EA, Wall GC. Pediatric constipation therapy using guidelines and polyethylene glycol 3350. Ann Pharmacol. 2004;38:686-693. (Pubitemid 38352235)
11. Youssef NN, Peters JM, Henderson W, et al. Dose response of PEG 3350 for the treatment of childhood fecal impaction. J Pediatr. 2002;141:410-414.
12. Tolia V, Lin C-H, Elitsur Y. A prospective randomized study with mineral oil and oral lavage solution for treatment of faecal impaction in children. Ailment Pharmacol Ther. 1993;7:523-529. (Pubitemid 23317884)
13. Pashankar DS, Loenig-Baucke V, Bishop WP. Safety of polyethylene glycol 3350 for the treatment of chronic constipation in children. Arch Pediatr Adolesc Med. 2003;157:661-664. (Pubitemid 36818646)
14. Michail S, Gendy E, Preud'Homme D, et al. Polyethylene glycol for constipation in children younger than eighteen months old. J Pediatr Gastroenterol Nutr. 2004;39:197-199.
15. Gremse DA, Hixon J, Crutchfield A. Comparison of polyethylene glycol 3350 and lactulose for treatment of chronic constipation in children. Clin Pediatr. 2000;41:225-229.
16. Candy D, Belsey J. Macrogol (polyethylene glycol) laxatives in children with functional constipation and fecal impactions: a systematic review. Arch Dis Child. 2009;94:156-160.
17. Nurko S, Youssef NN, Sabri M, et al. PEG3350 in the treatment of childhood constipation: a multicenter, double-blinded, placebo-controlled trial. J Pediatr. 2008;153:254-261.
18. Candy D, Edwards D, Geraint M. Treatment of faecal impaction with polyethylene glycol plus electrolytes (PGE + E) followed by a double-blind comparison of PEG + E versus lactulose as maintenance therapy. J Pediatr Gastroenterol Nutr. 2006;43:65-70. (Pubitemid 44022388)
19. Bekkali N, van den Berg M, Dijkgraaf MGW, et al. Rectal fecal impaction treatment in childhood constipation: enemas versus high doses of oral PEG. Pediatrics. 2009;124:e1108-e1115.
20. Pijpers MAM, Tabbers MM, Benninga MA, et al. Currently recommended treatments of childhood constipation are not evidence based: a systematic literature review on the effect of laxative treatment and dietary measures. Arch Dis Child. 2009;94:117-131.
21. Walker LS, Caplan-Dover A, Rasquin-Weber A. (2000) Manual for the Questionnaire on Gastrointestinal Symptoms. Nashville, TN: Department of Pediatrics, Vanderbilt University 2000.
22. Prashankar DS, Bishop WP. Efficacy and optimal dose of daily polyethylene glycol 3350 for treatment of constipation and encopresis in children. J Pediatr. 2001;139:428-432. (Pubitemid 32889521)
23. Altman DG, Schulz KF, Moher D, et al. The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med. 2001;134:663-694. (Pubitemid 32322245)
24. Miralax product information. Available at http://www.miralax.com/miralax/ hcp/productinformation.jsp. Accessed on December 1, 2009.
25. Altman DG. Practical Statistics for Medical Research. London Chapman & Hall; 1991.