Genetic association studies of ACE and PAI-1 genes in women with recurrent pregnancy loss: A systematic review and meta-analysis

Thrombosis and Haemostasis

Volumn 109, Issue 1, 2013, Pages 8-15

  Su, Mei Tsz ^a   Lin, Sheng Hsiang ^a   Chen, Yi Chi ^b   Kuo, Pao Lin ^a  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

ACE; Coagulation; Fibrinolysis; Meta analysis; PAI 1; Recurrent pregnancy loss

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ETHNICITY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; GESTATIONAL AGE; HUMAN; META ANALYSIS; PREGNANCY DISORDER; PRIORITY JOURNAL; REVIEW; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW;

ABORTION, HABITUAL; CONTINENTAL POPULATION GROUPS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GESTATIONAL AGE; HEMOSTASIS; HUMANS; ODDS RATIO; PEPTIDYL-DIPEPTIDASE A; PHENOTYPE; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, GENETIC; PREGNANCY; RISK FACTORS;

EID: 84872234137     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-08-0584     Document Type: Review

References (40)

1. Baek KH, et al. Recurrent pregnancy loss: the key potential mechanisms. Trends Mol Med 2007; 13: 310-317.
2. Goodman CS, et al. Which thrombophilic gene mutations are risk factors for recurrent pregnancy loss? Am J Reprod Immunol 2006; 56: 230-236.
3. Coulam CB, et al. Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage. Am J Reprod Immunol 2006; 55: 360-368.
4. Lussana F, et al. Pregnancy-related venous thromboembolism: Risk and the effect of thromboprophylaxis. Thromb Res 2012; 129: 673-680.
5. Kutteh WH, Triplett DA. Thrombophilias and recurrent pregnancy loss. Semin Reprod Med 2006; 24: 54-66.
6. Conserva V, et al. Recurrence and severity of abnormal pregnancy outcome in patients treated by low-molecular-weight heparin: a prospective pilot study. J Matern Fetal Neonatal Med 2012; in press.
7. Preston FE, et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348: 913-916.
8. Buchholz T, Thaler CJ. Inherited thrombophilia: impact on human reproduction. Am J Reprod Immunol 2003; 49: 1-13.
9. Reynolds LP, Redmer DA. Angiogenesis in the placenta. Biol Reprod 2001; 64: 1033-1040.
10. Schiessl B, et al. Localisation of angiogenic growth factors and their receptors in the human placental bed throughout normal human pregnancy. Placenta 2009; 30: 79-87.
11. Floridon C, et al. Does plasminogen activator inhibitor-1 (PAI-1) control trophoblast invasion? A study of fetal and maternal tissue in intrauterine, tubal and molar pregnancies. Placenta 2000; 21: 754-762.
12. Sartori MT, et al. 4G/5G polymorphism of PAI-1 gene promoter and fibrinolytic capacity in patients with deep vein thrombosis. Thromb Haemost 1998; 80: 956-960.
13. Festa A, et al. Promoter (4G/5G) plasminogen activator inhibitor-1 genotype and plasminogen activator-1 levels in blacks, Hispanics and non Hispanic whites: the Insulin Resistance Atherosclerosis Study. Circulation 2003; 20: 2422-2427.
14. Ridker PM, et al. Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II Evidence of a potential interaction between the renninangiotensin system and fibrinolytic function. Circulation 1993; 87: 1969-1973.
15. Kim DK, et al. Polymorphism of angiotensin converting enzyme gene is associated with circulating levels of plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol 1997; 17: 3242-3247.
16. Rigat B, et al. An insertion/deletion polymorphism in the angiotensin I converting enzyme gene accounts for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-1346.
17. Ueda S, et al. Enhanced pressor response to angiotensin I in normotensive men with the ACE deletion allele. Hypertension 1995; 25: 1266-1269.
18. Fatini C, et al. Angiotensin converting enzyme DD genotype, angiotensin type 1 receptor CC genotype, and hyperhomocysteinemia increase first-trimester fetal-loss susceptibility. Blood Coagul Fibrinolysis 2000; 11: 657-662.
19. Mello G, et al. Maternal-fetal flow, negative events, and preeclampsia: role of ACE I/D polymorphism. Hypertension 2003; 41: 932-937.
20. Dossenbach-Glaninger A, et al. ACE I/D polymorphism and recurrent first trimester pregnancy loss: interaction with SERPINE1 4G/5G and F13 Val34Leu polymorphisms. Br J Haematol 2008; 141: 269-271.
21. Goodman C, et al. Are polymorphisms in the ACE and PAI-1 genes associated with recurrent spontaneous miscarriages? Am J Reprod Immunol 2009; 62: 365-370.
22. Al Sallout RJ, Sharif FA. Polymorphisms in NOS3, ACE and PAI-1 genes and risk of spontaneous recurrent miscarriage in the Gaza Strip. Med Princ Pract 2010; 19: 99-104.
23. Aarabi M, et al. Polymorphisms of plasminogen activator inhibitor-1, angiotensin converting enzyme and coagulation factor XIII genes in patients with recurrent spontaneous abortion. J Matern Fetal Neonatal Med 2011; 24: 545-548.
24. Prisco D, et al. Angiotensin converting enzyme DD genotype affects the changes of plasma plasminogen activator inhibitor-1 activity after primary percutaneous transluminal coronary angioplasty in acute myocardial infarction patients. Int J Clin Lab Res 2000; 30: 179-185.
25. Ince DA, et al. The role of plasminogen activator inhibitor-1 and angiotensinconverting enzyme gene polymorphisms in bronchopulmonary dysplasia. Genet Test Mol Biomarkers 2010; 14: 643-647.
26. Güngör Y, et al. The presence of PAI-1 4G/5G and ACE DD genotypes increases the risk of early-stage AVF thrombosis in hemodialysis patients. Ren Fail 2011; 33: 169-175.
27. Agirbasli M, et al. Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease. Eur J Cardiovasc Prev Rehabil 2011; 18: 803-809.
28. Bora E, et al. Plasminogen activator inhibitor-1 and angiotensin converting enzyme gene polymorphisms in Turkish asthmatic children. Allergol Immunopathol 2012; in press.
29. Sotiriadis A, et al. Fibrinolytic defects and recurrent miscarriage: a systematic review and meta-analysis. Obstet Gynecol 2007; 109: 1146-1155.
30. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177-188.
31. Higgins JP, et al. Measuring inconsistency in meta-analyses. Br Med J 2003; 327: 557-560.
32. Egger M, et al. Bias in meta-analysis detected by a simple, graphical test. Br Med J 1997; 315: 629-634.
33. Zhang S, et al. Strong association between angiotensin I-converting enzyme I/D polymorphism and unexplained recurrent miscarriage of Chinese women-a case-control study. Reprod Sci 2011; 18: 743-746.
34. Ivanov P, et al. Plasminogen activator inhibitor type 1 activity in women with unexplained very early recurrent pregnancy loss. Akush Ginekol 2010; 49: 3-8.
35. Ivanov P, et al. Combined thrombophilic factors among women with late recurrent spontaneous abortions. Akush Ginekol 2011; 50: 8-12.
36. Alhenc-Gelas F, et al. The renin-angiotensin system in pregnancy and parturition. Adv Nephrol Necker Hosp 1986; 15: 25-33.
37. Vaughan DE. Fibrinolytic balance, the renin-angiotensin system and atherosclerotic disease. Eur Heart J 1998; 19: 9-12.
38. Suzuki Y, et al. Inflammation and angiotensin II. Int J Biochem Cell Biol 2003; 35: 881-900.
39. Vaughan DE, et al. Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin±angiotensin system and thrombosis. J Clin Invest 1995; 95: 995-1001.
40. Fatini C, et al. ACE DD genotype: an independent predisposition factor to venous thromboembolism. Eur J Clin Invest 2003; 33: 642-647.