Testosterone implants in women: Pharmacological dosing for a physiologic effect

Maturitas

Volumn 74, Issue 2, 2013, Pages 179-184

  Glaser, Rebecca ^a,b   Kalantaridou, Sophia ^c   Dimitrakakis, Constantine ^d,e  

^a Millennium Wellness Center   (United States)

^b WRIGHT STATE UNIVERSITY   (United States)

^c UNIVERSITY OF IOANNINA   (Greece)

^d UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^e EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Dosing; Efficacy; Implants; Serum levels; Testosterone; Women

Indexed keywords

TESTOSTERONE;

ANDROGEN DEFICIENCY; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG IMPLANT; DRUG PELLET; FEMALE; HORMONE SUBSTITUTION; HUMAN; IMPLANTATION; MAJOR CLINICAL STUDY; MENOPAUSE; POSTMENOPAUSE;

ANDROGENS; DRUG IMPLANTS; FEMALE; HUMANS; POSTMENOPAUSE; PREMENOPAUSE; STATISTICS, NONPARAMETRIC; TESTOSTERONE;

EID: 84872199243     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2012.11.004     Document Type: Article

References (29)

1. C.M. Wilson, and M.J. McPhaul A and B forms of the androgen receptor are expressed in a variety of human tissues Molecular and Cellular Endocrinology 120 1996 51 57
2. H. Takeda, G. Chodak, S. Mutchnik, T. Nakamoto, and C. Chang Immunohistochemical localization of androgen receptors with mono- and polyclonal antibodies to androgen receptor The Journal of Endocrinology 126 1990 17 25
3. H.G. Burger Androgen production in women Fertility and Sterility 77 2002 3 5
4. S.L. Davison, R. Bell, S. Donath, J.G. Montalto, and S.R. Davis Androgen levels in adult females: changes with age, menopause, and oophorectomy Journal of Clinical Endocrinology & Metabolism 90 2005 3847 3853
5. R. Glaser, A.E. York, and C. Dimitrakakis Beneficial effects of testosterone therapy in women measured by the validated Menopause Rating Scale (MRS) Maturitas 68 2011 355 361
6. S.N. Kalantaridou, and K.A. Callis Testosterone therapy in premenopausal women Seminars in Reproductive Medicine 24 2 2006 106 114
7. R Development Cor Team R: a language and environment for statistical computing 2012 R Foundation for Statistical Computing Vienna, Austria http://www.R-project.org/
8. R.L. Glaser, C. Dimitrakakis, and A.G. Messenger Improvement in scalp hair growth in androgen-deficient women treated with testosterone: a questionnaire study British Journal of Dermatology 166 2012 274 278
9. D.I. Spratt, L.S. O'dea, D. Schoenfeld, J. Butler, P.N. Rao, and W.F. Crowley Jr. Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone American Journal of Physiology: Endocrinology and Metabolism 254 1988 E658 E666
10. R. Glaser Subcutaneous testosterone-Anastrozole implant therapy in breast cancer survivors American Society of Clinical Oncology Breast Cancer Symposium 2010 D:221
11. R. Glaser, and C. Dimitrakakis Subgroups of patients treated with an aromatase inhibitor (anastrozole) delivered subcutaneously in combination with testosterone 9th European Congress on Menopause and Andropause 2012 A424:0001:00048
12. H.G. Burger, J. Hailes, M. Menelaus, J. Nelson, B. Hudson, and N. Balazs The management of persistent menopausal symptoms with oestradiol-testosterone implants: clinical, lipid and hormonal results Maturitas 6 1984 351 358
13. R.D. Gambrell Jr., and P.K. Natrajan Moderate dosage estrogen-Androgen therapy improves continuation rates in postmenopausal women: impact of the WHI reports Climacteric 9 2006 224 233
14. C. Dimitrakakis, R.A. Jones, A. Liu, and C.A. Bondy Breast cancer incidence in postmenopausal women using testosterone in addition to usual hormone therapy Menopause 11 2004 531
15. M.H. Thom, W.P. Collins, and J.W.W. Studd Hormonal profiles in postmenopausal women after therapy with subcutaneous implants BJOG: An International Journal of Obstetrics & Gynaecology 88 1981 426 433
16. A.M. Traish, and L.J. Gooren Safety of physiological testosterone therapy in women: lessons from female-to-male transsexuals (FMT) treated with pharmacological testosterone therapy The Journal of Sexual Medicine 7 2010 3758 3764
17. T.P. Van Staa, and J.M. Sprafka Study of adverse outcomes in women using testosterone therapy Maturitas 62 2009 76 80
18. G.D. Braunstein Safety of testosterone treatment in postmenopausal women Fertility and Sterility 88 2007 1 17
19. L.J. Gooren, E.J. Giltay, and M.C. Bunck Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience Journal of Clinical Endocrinology & Metabolism 93 2008 19 25
20. L.J.G. Gooren, and E.J. Giltay Review of studies of androgen treatment of female-to-male transsexuals: effects and risks of administration of androgens to females The Journal of Sexual Medicine 5 2008 765 776
21. A. Segaloff Hormone therapy of breast cancer Cancer Treatment Reviews 2 1975 129 135
22. S.R. Davis, M.J. Van Der Mooren, and R.H.W. van Lunsen Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial Menopause 13 2006 387
23. S.R. Davis, M. Moreau, and R. Kroll Testosterone for low libido in postmenopausal women not taking estrogen New England Journal of Medicine 359 2008 2005 2017
24. S.A. Kingsberg, J.A. Simon, and I. Goldstein The current outlook for testosterone in the management of hypoactive sexual desire disorder in postmenopausal women The Journal of Sexual Medicine 5 2008 182 193
25. R. Glaser, C. Dimitrakakis, N. Trimble, and V. Martin Testosterone pellet implants and migraine headaches: a pilot study Maturitas 71 2012 385 388
26. R.A. Lobo Androgens in postmenopausal women: production, possible role, and replacement options Obstetrical & Gynecological Survey 56 2001 361
27. R. Glaser, and C. Dimitrakakis Beneficial effects of subcutaneous testosterone on lipid profiles in women 9th European Congress on Menopause and Andropause 2012 A424:0009:00025
28. H.H. Choi, P.B. Gray, and T.W. Storer Effects of testosterone replacement in human immunodeficiency virus-infected women with weight loss Journal of Clinical Endocrinology & Metabolism 90 2005 1531 1541
29. M. Carruthers The paradox dividing testosterone deficiency symptoms and androgen assays: a closer look at the cellular and molecular mechanisms of androgen action The Journal of Sexual Medicine 5 2008 998