Testosterone therapy in premenopausal women

Seminars in Reproductive Medicine

Volumn 24, Issue 2, 2006, Pages 106-114

  Kalantaridou, Sophia N ^a   Calis, Karim A ^b,c  

^a UNIVERSITY OF IOANNINA   (Greece)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

Androgen insufficiency; Premenopausal women; Testosterone therapy

Indexed keywords

ANDROGEN; ANTICONVULSIVE AGENT; CORTICOSTEROID; ESTRADIOL; ESTRATEST; ESTROGEN; MEDROXYPROGESTERONE ACETATE; METHYLTESTOSTERONE; ORAL CONTRACEPTIVE AGENT; PRASTERONE; PRASTERONE SULFATE; TESTOSTERONE; TESTOSTERONE UNDECANOATE;

ACNE; ADRENAL FUNCTION; ADRENAL INSUFFICIENCY; ALOPECIA; AMENORRHEA; ANDROGEN DEFICIENCY; ARTICLE; ATHEROSCLEROSIS; BONE MASS; BREAST CANCER; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CLITORIS HYPERTROPHY; DIAGNOSTIC PROCEDURE; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; ENDOMETRIUM CANCER; FEMALE; GYNECOLOGIC DISEASE; HIRSUTISM; HORMONAL THERAPY; HORMONE DEFICIENCY; HUMAN; HYPOPITUITARISM; LARYNX DISORDER; LIBIDO; LIVER TOXICITY; MENOPAUSE; MOOD; MUSCLE MASS; OVARIECTOMY; OVARY FUNCTION; PATHOPHYSIOLOGY; PREMATURE OVARIAN FAILURE; PREMENOPAUSE; PREMENSTRUAL SYNDROME; SIDE EFFECT; SYMPTOMATOLOGY; TESTOSTERONE DEFICIENCY; TESTOSTERONE THERAPY; VAGINA BLEEDING; VIRILIZATION; WASTING SYNDROME; WEIGHT GAIN; WELLBEING;

ADULT; ANDROGENS; BONE AND BONES; BREAST NEOPLASMS; CARDIOVASCULAR DISEASES; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; LIBIDO; MIDDLE AGED; MUSCLE, SKELETAL; PREMENOPAUSE; RISK FACTORS; SEXUAL BEHAVIOR; TESTOSTERONE;

EID: 33646697754     PISSN: 15268004     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-939569     Document Type: Article

References (64)

1. Davis S. Androgen replacement in women: a commentary. J Clin Endocrinol Metab 1999;84:1886-1891
2. Abraham GE. Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle. J Clin Endocrinol Metab 1974;39:340-346
3. Judd HL, Lucas WE, Yen SS. Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer. Am J Obstet Gynecol 1974;118:793-798
4. Burger HG. Androgen production in women. Fertil Steril 2002;4(suppl):53-55
5. Mushayandebvu T, Castracane VD, Gimpel T, Adel T, Santoro N. Evidence for diminished midcycle ovarian androgen production in older reproductive aged women. Fertil Steril 1996;65:721-723
6. Zumoff B, Strain GW, Miller LK, Rosner W. Twenty-four hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocrinol Metab 1995;80:1429-1430
7. Davison SL, Bell R, Donath S, Montalto JG, Davis SR. Androgen levels in adult females: changes with age, menopause and oophorectomy. J Clin Endocrinol Metab 2005;90:3847-3853
8. Rainey WE, Carr BR, Sasano H, Suzuki T, Mason JI. Dissecting human adrenal androgen production. Trends Endocrinol Metab 2002;13:234-239
9. Orentreich N, Brind JL, Rizer RL, Vogelman JH. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab 1989;59:551-555
10. Notelovitz M. Androgen effects on bone and muscle. Fertil Steril 2002;4(suppl 4):534-541
11. McGriff-Lee N, Kalantaridou SN, Pucino F, Calis KA. Effects of androgens on bone in men and women. Clin Rev Bone Min Metab 2005;3:51-65
12. Slemenda C, Longcope C, Peacock M, Hui S, Johnston CC. Sex steroids, bone mass, and bone loss: a prospective study of pre-, peri-, and postmenopausal women. J Clin Invest 1996;97:14-21
13. Anasti JN, Kalantaridou SN, Kimzey LM, Defensor RA, Nelson LM. Bone loss in young women with karyotypically normal spontaneous premature ovarian failure. Obstet Gynecol 1998;91:12-15
14. Sherwin BB, Gelfand MM, Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Pscychosom Med 1985;47:339-351
15. Davis SR, Tran J. Testosterone influences libido and well being in women. Trends Endocrinol Metab 2001;12:33-37
16. Morris NM, Udry JR, Khan-Dawood F, Dawood MY. Marital sexual frequency and mid-cycle female testosterone. Arch Sex Behav 1987;16:27-37
17. Tutten A, Laan E, Panhuysen G, et al. Discrepancies between genital responses and subjective sexual function during testosterone substitution in women with hypothalamic amenorrhea. Psychosom Med 1996;58:234-241
18. Nathorst-Boos J, von Schoultz B. Psychological reactions and sexual life after hysterectomy with and without oophorectomy. Gynecol Obstet Invest 1992;34:97-101
19. Nathorst-Boos J, von Schoultz B, Carlstrom K. Elective ovarian removal and estrogen replacement therapy-effects on sexual life, psychological well-being and androgen status. J Psychosom Obstet Gynaecol 1993;14:283-293
20. Zussman L, Zussman S, Sunley R, Bjornson E. Sexual response after hysterectomy-oophorectomy: recent indices and reconsideration of psychogenesis. Am J Obstet Gynecol 1981;140:725-729
21. Davis SR, Davison SL, Donath S, Bell RJ. Circulating androgen levels and self-reported sexual function in women. JAMA 2005;294:91-96
22. Santoro N, Torrens J, Crawford S, et al. Correlates of circulating androgens in mid-life women: the study of Women's Health Across the Nation. J Clin Endocrinol Metab 2005;90:4836-4845
23. Kalantaridou SN, Calis KA, Vanderhoof VH, et al. Transdermal estradiol therapy significantly reduces serum free testosterone levels in young women with spontaneous premature ovarian failure. Abstract presented at: Annual Endocrine Society Meeting; June 4-7, 2005; San Diego, CA
24. Bermudez JA, Moran C, Herrera J, Barahona E, Perez MC, Zarate A. Determination of the steroidogenic capacity in premature ovarian failure. Fertil Steril 1993;60:668-671
25. Doldi N, Belvisi L, Bassan M, Fusi FM, Ferrari A. Premature ovarian failure: steroid synthesis and autoimmunity. Gynecol Endocrinol 1998;12:23-28
26. Miller KK, Sesmilo G, Schiller A, Schoenfeld D, Burton S, Klibanski A. Androgen deficiency in women with hypopituitarism. J Clin Endocrinol Metab 2001;86:561-567
27. Bloch M, Schmidt PJ, Su TP, Tobin MB, Rubinow DR. Pituitary-adrenal hormones and testosterone across the menstrual cycle in women with premenstrual syndrome and controls. Biol Psychiatry 1998;43:897-903
28. Dor J, Bider D, Shulman A, et al. Effects of gonadotropin-releasing hormone agonists on human ovarian steroid secretion in vivo and in vitro -results of a prospective, randomized in-vitro fertilization study. Hum Reprod 2000;15:1225-1230
29. Casson PR, Elkind-Hirsch KE, Buster JE, Hornsby PJ, Carson SA, Snabes MC. Effect of postmenopausal estrogen replacement on circulating androgens. Obstet Gynecol 1997;90:995-998
30. Bancroft J, Sherwin BB, Alexander GM, Davidson DW, Walker A. Oral contraceptives, androgens, and the sexuality of young women: II. The role of androgens. Arch Sex Behav 1991;20:121-134
31. Grinspoon S, Corcoran C, Stanley T, et al. Mechanisms of androgen deficiency in human immunodeficiency virus-infected women with the wasting syndrome. J Clin Endocrinol Metab 2001;86:4120-4126
32. Rosner W. The functions of corticosteroid-binding globulin and sex-hormone binding globulin: recent advances. Endocr Rev 1990;11:80-89
33. Bolour S, Braunstein G. Testosterone therapy in women: a review. Int J Impot Res 2005;17:399-408
34. Artl W, Callies F, van Vlijmen J, et al. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 1999;341:1013-1020
35. Kim M, Rosenfield R, Dupon C. The effects of dexamethasone on plasma free androgens during the normal menstrual cycle. Am J Obstet Gynecol 1976;126:982-986
36. Zumoff B, Walsh B, Katz J, et al. Subnormal plasma dehydroepiandrosterone to cortisol ratio in anorexia nervosa: a second hormone parameter of ontogenic regression. J Clin Endocrinol Metab 1983;56:668-672
37. Cunningham SK, McKenna TJ. Dissociation of adrenal androgens and cortisol secretion in Cushing's syndrome. Clin Endocrinol (Oxf) 1994;41:795-800
38. Goldstat R, Briganti E, Tran J, Wolfe R, Davis SR. Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women. Menopause 2003;10:390-398
39. Wilder RL. Adrenal and gonadal steroid hormone deficiency in the pathogenesis of rheumatoid arthritis. J Rheumatol Suppl 1996;44:10-12
40. Bachmann G, Bancroft J, Braunstein G, et al. Female androgen deficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil Steril 2002;77:660-665
41. Guay AT. Screening for androgen deficiency in women: methodological and interpretive issues. Fertil Steril 2002;77(suppl 4):83-88
42. Davis SR. When to suspect androgen deficiency other than at menopause. Fertil Steril 2002;77(suppl 4):568-571
43. Miller KK, Rosner W, Lee H, et al. Measurement of free testosterone in normal women and women with androgen deficiency: Comparison of methods. J Clin Endocrinol Metab 2004;89:525-533
44. Braunstein GD, Sundwall DA, Katz M, et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Arch Intern Med 2005;165:1582-1589
45. Davis SR, McCloud PI, Strauss BJG, Burger HG. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995;21:227-236
46. Lobo RA, Rosen RC, Yang HM, Block B, Van Der Hoop RG. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 2003;79:1341-1352
47. Raisz LG, Witta B, Artis A, et al. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. J Clin Endocrinol Metab 1996;81:37-43
48. Sarrel P, Dobay B, Wiita B. Estrogen and estrogen-androgen replacement in postmenopausal women dissatisfied with estrogen-only therapy. Sexual behavior and neuroendocrine responses. J Reprod Med 1998;43:847-856
49. Sherwin BB, Gelfand MM. The role of androgen in the maintenance of sexual functioning in oophorectomized women. Pscychosom Med 1987;49:397-409
50. Shifren JL, Braunstein G, Simon J, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000;343:682-688
51. Simon J, Braunstein G, Nachtigall L, et al. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 2005;90:5226-5233
52. Kalantaridou SN, Calis KA, Mazer NA, Godoy H, Nelson LM. A pilot study of an investigational transdermal testosterone patch system in young women with spontaneous premature ovarian failure. J Clin Endocrinol Metab 2005;90:6549-6552
53. Miller K, Corcoran C, Armstrong C, et al. Transdermal testosterone administration in women with aquired immunodeficiency syndrome wasting: a pilot study. J Clin Endocrinol Metab 1998;83:2717-2725
54. Dolan S, Wilkie S, Aliabadi N, et al. Effects of testosterone administration in human immunodeficiency virus-infected women with low weight. A randomized placebo-controlled study. Arch Intern Med 2004;164:897-904
55. Javanbakht M, Singh AB, Mazer NA, et al. Pharmacokinetics of a novel testosterone matrix transdermal system in healthy, premenopausal women and women infected with the human immunodeficiency virus. J Clin Endocrinol Metab 2000;85:2395-2401
56. Burger H, Davis SR. Should women be treated with testosterone. Clin Endocrinol (Oxf) 1998;49:159-160
57. Kalantaridou SN, Davis SR, Nelson LM. Premature ovarian failure. Endocrinol Metab Clin North Am 1998;27:989-1006
58. Worboys S, Kotsopoulos D, Teede H, McGrath B, Davis SR. Evidence that parenteral testosterone therapy may improve endothelium-dependent and -independent vasodilation in postmenopausal women already receiving estrogen. J Clin Endocrinol Metab 2001;86:158-161
59. Kravariti M, Naka KK, Kalantaridou SN, et al. Predictors of endothelial dysfunction in young women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:5088-5095
60. Sutton-Tyrrell K, Wildman RP, Matthews KA, et al. SWAN Investigators. Sex hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN). Circulation 2005;111:1242-1249
61. Kaaks R, Berrino F, Key T, et al. Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst 2005;97:755-765
62. Somboonporn W, Davis SR. Testosterone effects on breast: implications for testosterone therapy for women. Endocr Rev 2004;25:374-388
63. Tuckerman EM, Okon MA, Li TC, Laird SM. Do androgens have a direct inhibitory effect on endometrial function? An in vitro study. Fertil Steril 2000;74:771-779
64. Hickok LR, Toomey C, Speroff L. A comparison of esterified estrogens with and without methyltestosterone: effects on endometrial histology and serum lipoproteins in postmenopausal women. Obstet Gynecol 1993;82:919-924