In vivo metabolites and plasma exposure of TongMai Keli analyzed by UHPLC/DAD/qTOF-MS and LC/MS/MS

Journal of Ethnopharmacology

Volumn 145, Issue 2, 2013, Pages 509-516

  Liu, Chun Fang ^a   Qiao, Xue ^a   Liu, Ke Di ^a   Miao, Wen Juan ^a   Li, Yan Jiao ^a   Liu, Yang ^b   Jiang, Yan Yan ^b   Bo, Tao ^c   Shi, Ren Bing ^b   Guo, De An ^a   Ye, Min ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c AGILENT TECHNOLOGIES   (China)

Author keywords

LC MS MS; Metabolites identification; Pharmacokinetics; Plasma exposure; TongMai Keli; UHPLC DAD qTOF MS

Indexed keywords

BETA GLUCURONIDASE; CHINESE DRUG; DAIDZEIN; DRUG METABOLITE; FERULIC ACID; FORMONONETIN; GLUCURONIDE; GLYCITEIN; PUERARIN; SULFATE; TONGMAI KELI; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CHEMICAL REACTION; CHINESE MEDICINE; CONCENTRATION RESPONSE; CONJUGATION; CONTROLLED STUDY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; METABOLITE; NONHUMAN; PROTEIN HYDROLYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; ISOFLAVONES; MALE; MASS SPECTROMETRY; RATS; RATS, SPRAGUE-DAWLEY;

LIGUSTICUM CHUANXIONG; PUERARIA MONTANA VAR. LOBATA; RATTUS; SALVIA MILTIORRHIZA;

EID: 84872160734     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.11.021     Document Type: Article

References (33)

1. G. Chen, J.X. Zhang, and J.N. Ye Determination of puerarin, daidzein and rutin in Pueraria lobata (Wild.) Ohwi by capillary electrophoresis with electrochemical detection Journal of Chromatography A 923 2001 255 262
2. M.K. Choo, E.K. Park, H.K. Yoon, and D.H. Kim Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora Biological and Pharmaceutical Bulletin 25 2002 1328 1332
3. K.J. Gohil, S.B. Kshirsagar, and R.S. Sahane Ferulic acid - comprehensive pharmacology of important bioflavonoid International Journal of Pharmaceutical Sciences and Research 3 2012 700 710
4. W.L. Jiang, and X.H. Yuan Determination of salvianolic acid B in TongMai granules by HPLC China Pharmaceuticals 15 2006 27
5. S.E. Jin, Y.K. Son, B.S. Min, H.A. Jung, and J.S. Choi Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots Archives of Pharmacal Research 35 2012 823 837
6. S. Kayano, Y. Matsumura, Y. Kitagawa, M. Kobayashi, A. Nagayama, N. Kawabata, H. Kikuzaki, and Y. Kitada Isoflavone C-glycoside isolated from the root of kudzu (Pueraria lobata) and their estrogenic activities Food Chemistry 134 2012 282 287
7. W.M. Keung, and B.L. Vallee Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria Proceedings of the National Academy of Sciences of the United States of America 95 1998 2198 2203
8. W.R. LaCourse Column liquid chromatography: equipment and instrumentation Analytical Chemistry 74 2002 2813 2832
9. J.C. Lei, J.Q. Yu, and Y. Yao Determination of tanshinone IIA in TongMai granules by HPLC Chinese Journal of Modern Applied Pharmacy 23 2006 917 918
10. B.J. Li, C. Xiang, X.W. Yang, L.J. Wu, D.A. Guo, and M. Ye Fingerprints of Tongmai Keli by HPLC-DAD-MS Acta Pharmaceutica Sinica 45 2010 1410 1414
11. X. Li, C. Yu, Y. Lu, Y. Gu, J. Lu, W. Xu, L. Xuan, and Y. Wang Pharmacokinetics, tissue distribution, metabolism, and excretion of depside salts from Salvia miltiorrhiza in rats Drug Metabolism and Disposition 35 2007 234 239
12. C.F. Luo, M. Yuan, M.S. Chen, S.M. Liu, and M. Ji Metabolites of puerarin identified by liquid chromatography tandem mass spectrometry: similar metabolic profiles in liver and intestine of rats Journal of Chromatography B 878 2010 363 370
13. R.E. March, E.G. Lewars, C.J. Stadey, X.S. Miao, X. Zhao, and C.D. Metcalfe A comparison of flavonoid glycosides by electrospray tandem mass spectrometry International Journal of Mass Spectrometry 248 2006 61 85
14. E. Meezan, E.M. Meezan, K. Jones, R. Moore, S. Barnes, and J.K. Prasain Contrasting effects of puerarin and daidzin on glucose homeostasis in mice Journal of Agricultural and Food Chemistry 53 2005 8760 8767
15. Ministry of Health of the People's Republic of China Drug Standard-Chinese Medicinal Prescriptions vol. 4 1989 169
16. S. Takagi, M. Yamaki, and K. Inoue Flavone di-C-glycosides form Scutellaria Baicalensis Phytochemistry 20 1981 2443 2444
17. Y. Pan Simultaneous determination of danshensu, ferulic acid and puerarin in Tongmai granules by HPLC China Pharmacy 22 2011 376 378
18. J.K. Prasain, A. Reppert, K. Jones, D.R. Moore II, B. Barnes, and M.A. Lila Identification of isoflavone glycosides in Pueraria lobata cultures by tandem mass spectrometry Phytochemical Analysis 18 2007 50 59
19. U.S. Food and Drug Administration, 2001. Guidance for Industry-Bioanalytical Method Validation. Available from: 〈http://www.fda. gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM070107. pdf〉.
20. K. Vedavanam, S. Srijayanta, A. Raman, and H. Wiseman Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE) Phytotherapy Research 13 1999 601 608
21. C.H. Wang, X.M. Cheng, Y.Q. He, D.D. Mu, G.X. Chou, and Z.T. Wang Simultaneous determination of danshensu and puerarin in rat plasma by LC-MS-MS and its application to a pharmacokinetics and bioequivalence study after oral administration of Tongmai dripping pill and Tongmai oral solutions Chromatographia 70 2009 95 102
22. Y. Wang, Y.M. Yao, R. An, L.S. You, and X.H. Wang Simultaneous determination of puerarin, daidzein, baicalin, wogonoside, liquiritin of GegenQinlian decoction in rat plasma by ultra-performance chromatography-mass spectrometry Journal of Chromatography B 877 2009 1820 1826
23. P. Waridel, J.L. Wolfender, K. Ndjoko, K.R. Hobby, H.J. Major, and K. Hostettmann Evaluation of quadrupole time-of-flight tandem mass spectrometry and ion-trap multiple-stage mass spectrometry for the differentiation of C-glycosidic flavonoid isomers Journal of Chromatography A 926 2001 29 41
24. N. Wu, Y. Liu, and M.L. Lee Sub-2 μm porous and nonporous particles for fast separation in reversed-phase high performance liquid chromatography Journal of Chromatography A 1131 2006 142 150
25. C. Xiao, M. Sun, H.Y. Zhou, and Z.X. Qian Clinic research of TongMai granules on angina pectoris China Journal of Modern Medicine 14 2004 57 61
26. F.L. Xiong, X.H. Sun, L. Gan, X.L. Yang, and H.B. Xu Puerarin protects rat pancreatic islets from damage by hydrogen peroxide European Journal of Pharmacology 529 2006 1 7
27. R. Yan, S.L. Li, H.S. Chung, Y.K. Tam, and G. Lin Simultaneous quantification of 12 bioactive components of Ligusticum chuanxiong Hort. by high-performance liquid chromatography Journal of Pharmaceutical and Biomedical Analysis 37 2005 87 95
28. R. Yan, N.L. Ko, S.L. Li, Y.K. Tam, and G. Lin Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat Drug Metabolism and Disposition 36 2008 400 408
29. G.F. Zeng, H.B. Xiao, J.X. Liu, and X.M. Liang Identification of phenolic constituents in Radix Salvia miltiorrhizae by liquid chromatography/ electrospray ionization mass spectrometry Rapid Communications in Mass Spectrometry 20 2006 499 506
30. X.J. Zhai, H.B. Qu, and Q. Shao Studies of the synergistic actions of three herbs in Tong-Mai formula Chromatographia 69 2009 1267 1273
31. H.J. Zhang, and X.P. Yang Profiling and quantification of isoflavone-C-glycosides impurities in puerarin injection by liquid chromatography coupled to ESI-ion trap mass spectrometry Journal of Pharmaceutical and Biomedical Analysis 49 2009 843 847
32. + current in rat ventricular myocytes Acta Pharmacologica Sinica 24 2003 1212 1216
33. L. Zhou, and B.X. Han Study on quality control and clinical application of Tongmai granule Chinese Archives of Traditional Chinese Medicine 25 2007 1043 1044