Pathophysiological relevance of neutrophils in acetaminophen hepatotoxicity

Hepatology

Volumn 57, Issue 1, 2013, Pages 419-419

  Jaeschke, Hartmut ^a   Mcgill, Mitchell R ^a   Williams, C David ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARACETAMOL;

HUMAN; LETTER; LIVER INJURY; LIVER TOXICITY; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ACUTE-PHASE REACTION; ANIMALS; CHEMOKINES; DNA, MITOCHONDRIAL; FEMALE; HUMANS; LIVER; LIVER FAILURE, ACUTE; MALE; NEUTROPHILS; RECEPTORS, FORMYL PEPTIDE;

EID: 84872154566     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.25877     Document Type: Letter

References (6)

1. Marques PE, Amaral SS, Pires DA, Nogueira LL, Soriani FM, Lima BHF, et al. Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. HEPATOLOGY 2012. DOI: 10.1002/hep.25801.
2. McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest 2012; 122: 1574-1583.
3. Jaeschke H, Liu J. Neutrophil depletion protects against murine acetaminophen hepatotoxicity: another perspective. HEPATOLOGY 2007; 45: 1588-9158.
4. Jaeschke H. Innate immunity and acetaminophen-induced liver injury: why so many controversies? HEPATOLOGY 2008; 48: 699-701.
5. Jaeschke H, Williams CD, Ramachandran A, Bajt ML. Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity. Liver Int 2012; 32: 8-20.
6. Cover C, Liu J, Farhood A, Malle E, Waalkes MP, Bajt ML, et al. Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 2006; 216: 98-107.