Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms in ethnic Han women from Linyi

Chinese Journal of Medical Genetics

Volumn 29, Issue 6, 2012, Pages 705-708

  Zhang, Yan Li ^a   Lu, Yan Qiang ^b   Li, Hua Feng ^a   Rui, Xin Yi ^b   Zhang, Li Jun ^a   Wu, Chuan Ye ^a   Fang, Ai Min ^c   Wang, Gui Xi ^a  

^a Linyi Maternity and Child Health Hospital   (China)

^b Shanghai Institute of Targeted Therapy and Molecular Medicine   (China)

^c NONE

Author keywords

Homocysteine; Methionine synthase reductase; Methylenetetrahydrofolate reductase; Single nucleotide polymorphism

Indexed keywords

HOMOCYSTEINE;

ARTICLE; BIOCHEMISTRY; CHINA; EPITHELIUM CELL; ETHNICITY; GENE; GENE ACTIVITY; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; METHIONINE SYNTHASE REDUCTASE GENE; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; PROTEIN BLOOD LEVEL;

ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; FEMALE; FERREDOXIN-NADP REDUCTASE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENOTYPE; HOMOCYSTEINE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 84872143136     PISSN: 10039406     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.1003-9406.2012.06.018     Document Type: Article

References (14)

1. Bao R, Wu JX. Research progresses of molecular genetics in human neural tube defects. Chin J Birth Health Heredity, 2009, 17: 1-4.
2. Wang SM, Wang JH, Jia YF, et al. Genetic polymorphism of MTHFR 677C/T with non-syndromic cleft lip with or without cleft palate in Shandong area. Chin J Birth Health Heredity, 2011, 19: 6-8.
3. Shi J, Li F. Study on homocysteine, methylenetetrahydrofolate reductase and the relationship between folate and congenital heart disease. Chin Gener Pract, 2005, 8: 1551-1553.
4. Song LY, Qi QH, She DX, et al. Relationship between genetic polymorphism of homocysteine metabolism enzyme and unexplained repeated spontaneous abortion. Chin J Perinat Med, 2005, 8: 160-164.
5. Zuo JL, Yi JP, Chen BL. Advances in research of genes related to pregnancy induced hypertension. Maternal Child Health Care China, 2011, 26: 3822-3824.
6. Eskes TK. Open or closed? A world of difference: a history of homocysteine research. Nutr Rev, 1998, 56: 236-244.
7. Nishio K, Goto Y, Kan do T, et al. Serum folate and methyleuetetra- hydrofolate reductase (MTHFR) 677C/T polymorphisnl adjusted for folate intake. J Epidemiol, 2008, 18: 125-131.
8. Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation, 1996, 93: 7-9.
9. He XM, Zhang Q, Yang Q, et al. Study on the methylenetetrahydrofolate reductase and methionine synthase reductase polymorphism. Chin J Fam Plann, 2010, 18: 15-16.
10. Lao HH, He XM. Study on methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphism among the Han and Li women in Hainan Province. Chin J Fam Plann, 2011, 19: 655-657.
11. Chango A, Boisson F, Barbe F, et al. The effect of 677C→T and 1298A→C mutations on plasma homocysteine and 5, 10- methylenetetrahydrofolate reductase activity in healthy subjects. Br J Nutr, 2000, 83: 593-596.
12. Zhou FR, Zhang P, Fan YY, et al. Birth defects in Shandong, China, 2007-2010. Chin Prev Med, 2011, 12: 740-743.
13. Li ZW, Zhang H, Wang LN. Meta analysis on relationship between MTHFR gene polymorphism and susceptibility of coronary heart disease and neural tube defects in Chinese population. Chin J Prev Contr Chron Non-commun Dis, 2004, 12: 163-165.
14. Han IB, Kim OJ, Ahn JY, et al. Association of methylenetetrahydrofolate reductase (MTHFR 677C>T and 1298A>C) polymorphisms and haplotypes with silent brain infarction and homocysteine levels in a Korean population. Yonsei Med J, 2010, 51: 253-260.