Complement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients

International Immunology

Volumn 25, Issue 1, 2013, Pages 25-33

  Kremlitzka, Mariann ^a   Polgár, Anna ^b   Fülöp, Lívia ^c   Kiss, Emese ^b   Poór, Gyula ^b   Erdei, Anna ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b National Rheumatology and Physiotherapy Institute   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Autoimmunity; B cell subpopulations; Expression of CR1 and CR2; Inhibition of B cell function

Indexed keywords

CD19 ANTIGEN; CD27 ANTIGEN; CHLOROQUINE; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C3D RECEPTOR; COMPLEMENT RECEPTOR; LEFLUNOMIDE; METHOTREXATE; METHYLPREDNISOLONE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISOLONE; SALAZOSULFAPYRIDINE; THYMIDINE DERIVATIVE; THYMIDINE H 3; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BLOOD SAMPLING; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GROWTH INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MALE; MEMORY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; RHEUMATOID ARTHRITIS;

ADULT; AGED; ANTIGENS, CD19; ANTIGENS, CD27; ARTHRITIS, RHEUMATOID; AUTOIMMUNITY; B-LYMPHOCYTES; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, HUMORAL; IMMUNOLOGIC MEMORY; MALE; MIDDLE AGED; PERIPHERAL TOLERANCE; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, COMPLEMENT 3B; RECEPTORS, COMPLEMENT 3D; SIGNAL TRANSDUCTION;

EID: 84872138413     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxs090     Document Type: Article

References (43)

1. Feldmann, M., Brennan, F. M. and Maini, R. N. 1996. Rheumatoid arthritis. Cell 85:307.
2. Ballanti, E., Perricone, C., di Muzio, G. et al. 2011. Role of the complement system in rheumatoid arthritis and psoriatic arthritis: relationship with anti-TNF inhibitors. Autoimmun. Rev. 10:617.
3. Moffat, G. J., Lappin, D., Birnie, G. D. and Whaley, K. 1989. Complement biosynthesis in human synovial tissue. Clin. Exp. Immunol. 78:54.
4. Okroj, M., Heinegard, D., Holmdahl, R. and Blom, A. M. 2007. Rheumatoid arthritis and the complement system. Ann. Med. 39:517.
5. Trouw, L. A., Haisma, E. M., Levarht, E. W. et al. 2009. Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways. Arthritis. Rheum. 60:1923.
6. Hikada, M. and Zouali, M. 2010. Multistoried roles for B lymphocytes in autoimmunity. Nat. Immunol. 11:1065.
7. O'Neill, S. K., Shlomchik, M. J., Glant, T. T., Cao, Y., Doodes, P. D. and Finnegan, A. 2005. Antigen-specific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis. J. Immunol. 174:3781.
8. Schroder, A. E., Greiner, A., Seyfert, C. and Berek, C. 1996. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc. Natl. Acad. Sci. U. S. A. 93:221.
9. Pongratz, G. and Straub, R. H. 2008. B-cell involvement in the pathogenesis of RA-is there a contribution of the sympathetic nervous system? Immunol. Res. 40:148.
10. Dunkelberger, J. R. and Song, W. C. 2010. Complement and its role in innate and adaptive immune responses. Cell Res. 20:34.
11. Erdei, A., Isaak, A., Torok, K. et al. 2009. Expression and role of CR1 and CR2 on B and T lymphocytes under physiological and autoimmune conditions. Mol. Immunol. 46:2767.
12. Nimmerjahn, F. and Ravetch, J. V. 2008. Fcgamma receptors as regulators of immune responses. Nat. Rev. Immunol. 8:34.
13. Fearon, D. T. 1980. Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte. J. Exp. Med. 152:20.
14. Zipfel, P. F. and Skerka, C. 2009. Complement regulators and inhibitory proteins. Nat. Rev. Immunol. 9:729.
15. Jozsi, M., Prechl, J., Bajtay, Z. and Erdei, A. 2002. Complement receptor type 1 (CD35) mediates inhibitory signals in human B lymphocytes. J. Immunol. 168:2782.
16. Fischer, M. B., Goerg, S., Shen, L. et al. 1998. Dependence of germinal center B cells on expression of CD21/CD35 for survival. Science 280:582.
17. Carroll, M. C. 1998. The role of complement and complement receptors in induction and regulation of immunity. Ann. Rev. Immunol. 16:545.
18. Iida, K., Nadler, L. and Nussenzweig, V. 1983. Identification of the membrane receptor for the complement fragment C3d by means of a monoclonal antibody. J. Exp. Med. 158:1021.
19. Fingeroth, J. D., Weis, J. J., Tedder, T. F., Strominger, J. L., Biro, P. A. and Fearon, D. T. 1984. Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc. Natl. Acad. Sci. U. S. A. 81:4510.
20. Aubry, J. P., Pochon, S., Graber, P., Jansen, K. U. and Bonnefoy, J. Y. 1992. CD21 is a ligand for CD23 and regulates IgE production. Nature 358:505.
21. Dempsey, P. W., Allison, M. E., Akkaraju, S., Goodnow, C. C. and Fearon, D. T. 1996. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271:348.
22. Isaak, A., Gergely, P., Jr, Szekeres, Z. et al. 2008. Physiological up-regulation of inhibitory receptors Fc gamma RII and CR1 on memory B cells is lacking in SLE patients. Int. Immunol. 20:185.
23. Wilson, J. G., Ratnoff, W. D., Schur, P. H. and Fearon, D. T. 1986. Decreased expression of the C3b/C4b receptor (CR1) and the C3d receptor (CR2) on B lymphocytes and of CR1 on neutrophils of patients with systemic lupus erythematosus. Arthritis. Rheum. 29:739.
24. Del Nagro, C. J., Kolla, R. V. and Rickert, R. C. 2005. A critical role for complement C3d and the B cell coreceptor (CD19/CD21) complex in the initiation of inflammatory arthritis. J. Immunol. 175:5379.
25. Kuhn, K. A., Cozine, C. L., Tomooka, B., Robinson, W. H. and Holers, V. M. 2008. Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens. Mol. Immunol. 45:2808.
26. Nilsson, K. E., Andren, M., Diaz de Stahl, T. and Kleinau, S. 2009. Enhanced susceptibility to low-dose collagen-induced arthritis in CR1/2-deficient female mice-possible role of estrogen on CR1 expression. FASEB J. 23:2450.
27. Catalan, D., Aravena, O., Sabugo, F. et al. 2010. B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgammaRIIb, which are modulated by anti-tumor necrosis factor therapy. Arthritis Res. Ther. 12:R68.
28. Prokopec, K. E., Rhodiner, M., Matt, P., Lindqvist, U. and Kleinau, S. 2010. Down regulation of Fc and complement receptors on B cells in rheumatoid arthritis. Clin. Immunol. 137:322.
29. Munson, L. G., Scott, M. E., Landay, A. L. and Spear, G. T. 1995. Decreased levels of complement receptor 1 (CD35) on B lymphocytes in persons with HIV infection. Clin. Immunol. Immunopathol. 75:20.
30. Jacobson, A. C. and Weis, J. H. 2008. Comparative functional evolution of human and mouse CR1 and CR2. J. Immunol. 181:2953.
31. Tsokos, G. C., Berger, M. and Balow, J. E. 1984. Modulation of human B cell immunoglobulin secretion by the C3b component of complement. J. Immunol. 132:622.
32. Weiss, L., Delfraissy, J. F., Vazquez, A., Wallon, C., Galanaud, P. and Kazatchkine, M. D. 1987. Monoclonal antibodies to the human C3b/C4b receptor (CR1) enhance specific B cell differentiation. J. Immunol. 138:2988.
33. Arnett, F. C., Edworthy, S. M., Bloch, D. A. et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315.
34. Prevoo, M. L., van 't Hof, M. A., Kuper, H. H., van Leeuwen, M. A., van de Putte, L. B. and van Riel, P. L. 1995. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 38:44.
35. Basta, M. and Hammer, C. H. 1991. A rapid FPLC method for purification of the third component of human and guinea pig complement. J. Immunol. Methods 142:39.
36. Isenman, D. E., Kells, D. I., Cooper, N. R., Muller-Eberhard, H. J. and Pangburn, M. K. 1981. Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties. Biochemistry 20:4458.
37. Tedder, T. F., Clement, L. T. and Cooper, M. D. 1984. Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody. J. Immunol. 133:678.
38. Arpin, C., Dechanet, J., Van Kooten, C. et al. 1995. Generation of memory B cells and plasma cells in vitro. Science 268:720.
39. Zikherman, J. and Weiss, A. 2009. Antigen receptor signaling in the rheumatic diseases. Arthritis Res. Ther. 11:202.
40. Kammer, G. M. and Schur, P. H. 1978. Binding of circulating immune complexes to human peripheral blood lymphocytes: effect of complement. Clin. Immunol. Immunopathol. 10:202.
41. Nakamura, A. and Takai, T. 2004. A role of FcgammaRIIB in the development of collagen-induced arthritis. Biomed. Pharmacother. 58:292.
42. Mackay, M., Stanevsky, A., Wang, T. et al. 2006. Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE. J. Exp. Med. 203:2157.
43. Voynova, E., Tchorbanov, A., Prechl, J. et al. 2008. An antibody-based construct carrying DNA-mimotope and targeting CR1(CD35) selectively suppresses human autoreactive B-lymphocytes. Immunol. Lett. 116:168.