Physiological up-regulation of inhibitory receptors FcγRII and CR1 on memory B cells is lacking in SLE patients

International Immunology

Volumn 20, Issue 2, 2008, Pages 185-192

  Isaák, Andrea ^a   Gergely Jr , Péter ^b   Szekeres, Zsuzsanna ^a   Prechl, József ^a   Poór, Gyula ^b   Erdei, Anna ^a   Gergely, János ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b National Rheumatology and Physiotherapy Institute   (Hungary)

Author keywords

Autoimmunity; IC binding receptors

Indexed keywords

CD19 ANTIGEN; CD27 ANTIGEN; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C3D RECEPTOR; FC RECEPTOR; IMMUNOGLOBULIN M;

ARTICLE; COMPLEMENT SYSTEM; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; PERIPHERAL LYMPHOCYTE; PLASMA CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR UPREGULATION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANTIGENS, CD19; ANTIGENS, CD27; AUTOIMMUNITY; B-LYMPHOCYTE SUBSETS; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN M; IMMUNOLOGIC MEMORY; LUPUS ERYTHEMATOSUS, SYSTEMIC; RECEPTORS, COMPLEMENT; RECEPTORS, COMPLEMENT 3D; RECEPTORS, IGG; UP-REGULATION;

EID: 39049103516     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxm132     Document Type: Article

References (32)

1. Takai, T 2002. Roles of Fc receptors in autoimmunity. Nat. Rev. Immunol. 2:580.
2. Schmidt, R. E. and Gessner, J.E. 2005. Fc receptors and their interaction with complement in autoimmunity. Immunol. Lett. 100:56.
3. Iida, K., Mornaghi, R. and Nussenzweig, V. 1982. Complement receptor (CR1) deficiency in erythrocyies from patients with systemic lupus erythematosus. J. Exp. Med. 155:1427.
4. Arora, V., Verma, J., butta, R., Marwah., V., Kumar, A. and Das, N 2004. Reduced complement receptor 1 (CR1 CD35) transcription in systemic lupus erythematosus. Mol. Immunol. 41:449.
5. Arora, V., Verma, J., Dutta, R. Merwah, V., Kumar, A. and Das, N. 2004. Reduced complement receptor 1 (CR1, CD35) transcription in systemic lupus erythematosus. Mol. Immunol. 41:449.
6. Wilson, J. G., Ratnoff , W. D., Schur, P.H and Fearon, D. T. 1986. Decreased expression of the C3b/C4b recepfor (CR1) and the C3d receptor (CR2) on B lymphocytes and of CR1 on neutrophils of patients with systemic lupus erythematosus. Arthritis Rheum. 29:739.
7. Illges, H., Braun, M., Peter, H. H. and Melchers, I. 2000. Reduced expression of the complement receptor type 2 (CR2, CD21) by synovial fluid B and T lymphocytes. Clin. Exp. Immunol. 122:270.
8. Wilson, J. G., Murphy, E. E., Wong, W. W., Klickstein, L. B., Weis, J. H. and Fearon, D. T. 1986. Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erythrocytes. J. Exp. Med. 164:50.
9. Floto, R. A., Clatworthy, M. R., Heilbronn, K. R. et al. 2005. Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts. Nat. Med. 11:1056.
10. Kono, H., Kyogoku, C., Suzuki, T. et al. 2005. FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling. Hum. Mol. Genet. 14:2881.
11. Blank, M. C., Stefanescu, R. N., Masuda, E. et al. 2005. Decreased transcription of the human FCGR2B gene mediated by the 343 G/C promoter polymorphism and association with systemic lupus erythematosus. Hum. Genet. 117:220.
12. Tan, E.M., Cohen, A. S., Fries, J. F. et al. 1982. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25:1271.
13. Bombardier, C., Gladman, D. D., Urowitz, M. B., Caron, D. and Chang, G. H. 1992. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum. 35:630.
14. Mackay, M., Stanevsky, A., Wang, T. et al. 2006. Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE. J. Exp. Med. 203:2157.
15. Gergely, P. Jr., Isaak, A., Szekeres, Z. et al. 2007. Altered expression of Fcgamma and complement receptors on B cells in systemic lupus erythematosus. Ann. N. Y. Acad. Sci. 1108:183.
16. Takahashi, K., Kozono, Y., Waldschmidt, T. J. et al. 1997. Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): Expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/1pr mice. J. Immunol. 159:1557.
17. Jozsi, M., Prechl, J., Bajtay, Z. and Erdei, A. 2002. Complement receptor type 1 (CD35) mediates inhibitory signals in human B lymphocytes. J. Immunol. 168:2782.
18. Mongini, P. K., Vilensky M. A., Highet, P. F. and Inman, J. K. 1997. The affinity threshold for human B cell activation via the antigen receptor complex is reduced upon co-ligation of the antigen receptor with CD21 (CR2). J. Immunol. 159:3782.
19. Potter, K. N., Mockridge, C. I., Rahman, A. et al. 2002. Disturbances in peripheral blood B cell subpopulations in autoimmune patients. Lupus 11:872.
20. Takai, T. 2005. Fc receptors and their role in immune regulation and autoimmunity. J. Clin. Immunol. 25:1.
21. Boackle, S. A. 2003. Complement and autoimmunity. Biomed. Pharmacother. 57:269.
22. Erdei, A., Prechl, J., Isaak, A. and Molnar, E. 2003. Regulation of B-cell activation by complement receptors CD21 and CD35. Curr. Pharm. Des. 9:1849.
23. Daeron, M., Latour, S., Malbec, O. et al. 1995. The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR- dependent cell activation. Immunity 3:635.
24. Wagner, C. Ochmann, C., Schoels, M. et al. 2006. The complement receptor 1, CR1 (CD35), mediates inhibitory signals in human T-lymphocytes. Mol. Immunol. 43:643.
25. Mongini, P. K., Vilensky, M. A., Highet, P. F. and Inman, J. K. 1997. The affinity threshold for human B cell activation via the antigen receptor complex is reduced upon co-ligation of the antigen receptor with CD21 (CR2). J. Immunol. 159:3782.
26. Tangye, S. G., Avery, D. T. and Hodgkin, P. D. 2003. A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells. J. Immunol. 170:261.
27. Tsuiji, M., Yurasov, S., Velinzon, K., Thomas, S., Nussenzweig, M. C. and Wardemann, H. 2006. A checkpoint for autoreactivity in human IgM+ memory cell development. J. Exp. Med. 203:393.
28. Tiller, T., Tsuiji, M., Yurasov, S., Velinzon, K., Nussenzweig, M. C. and Wardemannm, H. 2007. Autoreactivity in human IgG+ memory B cells. Immunity 26:205.
29. Fukuyama, H., Nimmerjahn, F. and Ravetch, J. V. 2005. The inhibitory Fcgamma receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells. Nat. Immunol. 6:99.
30. Masilamani, M., Kassahn, D., Mikkat, S., Glocker, M. O. and Illges, H. 2003. B cell activation leads to shedding of complement receptor type II (CR2/CD21). Eur. J. Immunol. 33:2391.
31. Danielsson, C., Pascual, M., French, L., Steiger, G. and Schifferli, J. A. 1994. Soluble complement receptor type 1 (CD35) is released from leukocytes by surface cleavage. Eur. J. Immunol. 24:2725.
32. Sarmay, G., Rozsnyay, Z., Koncz, G., Danilkovich, A. and Gergely, J. 1995. The alternative splicing of human Fc gamma RII mRNA is regulated by activation of B cells with mlgM cross-linking, interleukin-4, or phorbolester. Eur. J. Immunol. 25:262.