Summary of workshop discussions on establishing upper limits for amino acids with specific attention to available data for the essential amino acids leucine and tryptophan

Journal of Nutrition

Volumn 142, Issue 12, 2012, Pages

  Kimura, Takeshi ^a   Bier, Dennis M ^b   Taylor, Christine L ^c  

^a AJINOMOTO CO INC   (Japan)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; LEUCINE; TRYPTOPHAN;

ARTICLE; DIET SUPPLEMENTATION; DOSE RESPONSE; HUMAN; NONHUMAN; NUTRIENT LIMITATION; PROTEIN INTAKE; RISK ASSESSMENT;

ANIMALS; DIETARY SUPPLEMENTS; HUMANS; LEUCINE; NUTRITION POLICY; NUTRITIONAL REQUIREMENTS; TRYPTOPHAN;

ANIMALIA; RODENTIA; SUIDAE;

EID: 84872132600     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.112.160846     Document Type: Article

References (14)

1. Ross AC, Russell RM, Miller SA, Munro IC, Rodricks JV, Yetley EA, Julien E. Application of a key events dose-response analysis to nutrients: a case study with vitamin A (retinol). Crit Rev Food Sci Nutr. 2009;49: 708-17.
2. Dellarco VL, Fenner-Crisp PA. Mode of action: moving toward a more relevant and efficient assessment paradigm. J Nutr. 2012;142:2192S-98S.
3. Taylor CL, Meyers LD. Perspectives and progress on upper levels of intake in the United States. J Nutr. 2012;142:2207S-11S.
4. Millward DJ. Knowledge gained from studies of leucine consumption in animals and humans. J Nutr. 2012;142:2212S-19S.
5. Tsubuku S, Hatayama K, Katsumata T, Nishimura N, Mawatari K, Smriga M, Kimura T. Thirteen-week oral toxicity study of branched-chain amino acids in rats. Int J Toxicol. 2004;23:119-26.
6. Kato H, Imamura W, Kanamoto R. Adverse effects of excessive leucine intake depend on dietary protein intake: a transcriptomic analysis to identify useful biomarkers.. J of Nutritional Science and Vitaminology. 2013; (in press).
7. Carrizo LC, Ruete CM, Manucha WA, Ciocca DR, Vallés PG. Heat shock protein 70 expression is associated with inhibition of renal tubule epithelial cell apoptosis during recovery from low-protein feeding. Cell Stress Chaperones. 2006;11:309-24.
8. Pencharz PB, Elango R, Ball RO. Determination of the tolerable upper intake of leucine in adult men. J Nutr. 2012;142:2220S-24S.
9. Breen L, Phillips SM. Skeletal muscle protein metabolism in the elderly: interventions to counteract the "anabolic resistance" of ageing. Nutr Metab (Lond). 2011;5:8:68.
10. Fernstrom JD. Effects and side effects associated with the nonnutritional use of tryptophan by humans. J Nutr. 2012;142:2236S-44S.
11. Simat T, van Wickern B, Eulitz K, Steinhart EH. Contaminants in biotechnologically manufactured L-tryptophan. J Chromatogr B Biomed Appl. 1996;685:41-51.
12. Moehn S, Pencharz PB, Ball RO. Lessons learned regarding symptoms of tryptophan deficiency and excess from animal requirement studies. J Nutr. 2012;142:2231S-35S.
13. Shibata K, Fukuwatari T. The metabolites in the tryptophan degradation pathway might be useful to determine the tolerable upper intake level of tryptophan intake in rats. J Nutr. 2012;142:2227S-30S.
14. Pencharz PB, Russell RM. Application of Key Events Sose Response Framework to defining the upper intake level of leucine in young men. J Nutr. 2012;142:2225S-26S.